Ziftum tablets

Ziftum

  • Active Ingredient: Cefuroxime
  • 500 mg, 250 mg
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What is Ziftum?

The active ingredient of Ziftum brand is cefuroxime. Cefuroxime is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in your body.

Used for

Ziftum is used to treat diseases such as: Bacterial Infection, Bladder Infection, Bone infection, Bronchitis, Epiglottitis, Gonococcal Infection, Disseminated, Gonococcal Infection, Uncomplicated, Impetigo, Joint Infection, Kidney Infections, Lyme Disease, Meningitis, Otitis Media, Peritonitis, Pneumonia, Sepsis, Sinusitis, Skin and Structure Infection, Skin or Soft Tissue Infection, Strep Throat, Surgical Prophylaxis, Tonsillitis/Pharyngitis, Upper Respiratory Tract Infection, Urinary Tract Infection, Wound Infection.

Side Effect

Possible side effects of Ziftum include: thick, white vaginal discharge with no odor or with a mild odor; stuffy or runny nose; fever with or without chills; decrease in urine output or decrease in urine-concentrating ability; cough or hoarseness.

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What is Ziftum (Ceftin)?

Ziftum is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in your body.

Ziftum is used to treat many kinds of bacterial infections, including severe or life-threatening forms.

Ziftum may also be used for purposes not listed in this medication guide.

Pregnancy

Pregnancy Category B. There are no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, CEFTIN should be used during pregnancy only if clearly needed.

Reproduction studies have been performed in mice at doses up to 3,200 mg/kg/day (14 times the recommended maximum human dose based on body surface area) and in rats at doses up to 1,000 mg/kg/day (9 times the recommended maximum human dose based on body surface area) and have revealed no evidence of impaired fertility or harm to the fetus due to Ziftum axetil.

If you have a bacterial infection, you may benefit from Ziftum axetil. Uses of this medication include treatment of tonsillitis, strep throat, ear infections, skin infections, and bronchitis, to name a few. This prescription medication works by preventing the bacteria from forming cell walls. It is approved for use in both adults and children (as young as three months old).

Our free DiscountRx savings card can help you and your family save money on your prescriptions. This card is accepted at all major chain pharmacies, nationwide. Enter your name and email address to receive your free savings card.

Our free DiscountRx savings card can help you and your family save money on your prescriptions. This card is accepted at all major chain pharmacies, nationwide. Enter your name and email address to receive your free savings card.

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CEFTIN (Ziftum axetil) Tablets, for Oral Use

CEFTIN (Ziftum axetil) for Oral Suspension

Drug/Laboratory Test Interactions

A false-positive reaction for glucose in the urine may occur with copper reduction tests (e.g., Benedict's or Fehling's solution), but not with enzyme-based tests for glycosuria. As a false-negative result may occur in the ferricyanide test, it is recommended that either the glucose oxidase or hexokinase method be used to determine blood/plasma glucose levels in patients receiving Ziftum axetil. The presence of Ziftum does not interfere with the assay of serum and urine creatinine by the alkaline picrate method.

What other drugs will affect Ziftum (Ceftin)?

Tell your doctor about all your current medicines and any you start or stop using, especially:

This list is not complete. Other drugs may interact with Ziftum, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Ziftum axetil is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Ziftum axetil has activity in the presence of some β-lactamases, both penicillinases and cephalosporinases, of gram-negative and gram-positive bacteria.

What should I avoid while taking Ziftum?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

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Ziftum is suitable for adults and children, and can be taken during pregnancy. Some people who are allergic to penicillin antibiotics may not be able to take Ziftum, so make sure your doctor knows if you have ever had an allergic reaction to any other antibiotic.

Drug Levels

Maternal Levels. A single intravenous dose of 750 mg of Ziftum was given to 5 women. The average peak Ziftum level in milk was 0.37 mg/L 3 hours after the dose. Individual peak levels of 0.33 to 0.5 mg/L occurred 2 to 4 hours after the dose.

A single intramuscular injection of 750 mg of Ziftum was given to 8 women with endometritis. Milk Ziftum levels increased from 0.34 mg/L at 30 minutes after the injection to 1.45 mg/L at 8 hours after the injection.

After Ziftum 750 mg three times daily intramuscularly, peak milk levels averaging 1.2 mg/L occurred 6 hours after the dose. Ziftum was detectable at a concentration of 0.36 mg/L 30 minutes after the dose, and by 8 hours the milk level had decreased to 1.06 mg/L.

One mother received Ziftum axetil 500 mg orally three times daily for acute mastitis of the left breast following incision and drainage of the lesion. Milk samples were taken from each breast 30 minutes after the dose on day 1 of therapy. The concentration of Ziftum in the unaffected breast was 90 mcg/L and the concentration in the breast treated for mastitis was 590 mcg/L. On day 2 of therapy, milk samples from the right and left breast were taken 90 minutes after the dose were 57 and 59 mcg/L, respectively. On day 3, milk samples obtained 90 minutes after the dose contained 27 mcg/L in the unaffected breast and 1.07 mg/L in the affected breast.

Two women were who had been receiving intravenous Ziftum 750 mg 3 times daily for 2 days following cesarean section donated milk samples 1 hours after the dose. Milk concentrations were 0.34 and 0.39 mg/L.

Infant Levels. Relevant published information was not found as of the revision date.

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Storage And Handling

CEFTIN tablets, 250 mg of Ziftum (as Ziftum axetil), are white, capsule-shaped, film-coated tablets engraved with “GX ES7” on one side and blank on the other side as follows: 20 Tablets/Bottle NDC 0173-0387-00

CEFTIN tablets, 500 mg of Ziftum (as Ziftum axetil), are white, capsule-shaped, film-coated tablets engraved with “GX EG2” on one side and blank on the other side as follows: 20 Tablets/Bottle NDC 0173-0394-00

Store the tablets between 15° and 30°C (59° and 86°F). Replace cap securely after each opening.

CEFTIN for oral suspension is provided as dry, white to off-white, tutti-frutti-flavored powder. When reconstituted as directed, the suspension provides the equivalent of 125 mg or 250 mg of Ziftum (as Ziftum axetil) per 5 mL. It is supplied in amber glass bottles as follows:

For Healthcare Professionals

Applies to Ziftum: injectable powder for injection, intravenous solution, oral powder for reconstitution, oral tablet


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