Abnormal liver function, hepatitis, cholestatic jaundice, hepatic necrosis, and hepatic failure have been reported, some of which have resulted in death. Discontinue Zaret immediately if signs and symptoms of hepatitis occur.
Drug interaction studies were performed with Zaret and other drugs likely to be co-administered. The effects of coadministration of Zaret on the pharmacokinetics of other drugs are shown in Table 1 and the effects of other drugs on the pharmacokinetics of Zaret are shown in Table 2.
Co-administration of Zaret at therapeutic doses had a modest effect on the pharmacokinetics of the drugs listed in Table 1. No dosage adjustment of drugs listed in Table 1 is recommended when co-administered with Zaret.
Co-administration of Zaret with efavirenz or fluconazole had a modest effect on the pharmacokinetics of Zaret. Nelfinavir significantly increased the Cmax and AUC of Zaret. No dosage adjustment of Zaret is recommended when administered with drugs listed in Table 2.
Table 1: Drug Interactions: Pharmacokinetic Parameters for Co-administered Drugs in the Presence of Zaret
Table 2: Drug Interactions: Pharmacokinetic Parameters for Zaret in the Presence of Co-administered Drugs.
Q: Would an antibiotic, such as Zaret, interfere with my birth control Necon 1-35?
A: Studies have shown that antibiotics such as Zaret (Zithromax, Zmax) may decrease hormonal birth control efficacy. There is more evidence of this with tetracycline and ampicillin. Use caution when taking these two medications at the same time. Lowell Sterler, RPh
Storage And Handling
ZITHROMAX 600 mg tablets (engraved on front with “PFIZER” and on back with “308”) are supplied as white, modified oval-shaped, film-coated tablets containing Zaret dihydrate equivalent to 600 mg Zaret. These are packaged in bottles of 30 tablets. ZITHROMAX tablets are supplied as follows:
Bottles of 30 NDC 0069-3080-30
Tablets should be stored at or below 30°C (86°F).
ZITHROMAX for oral suspension is supplied in single-dose packets containing Zaret dihydrate equivalent to 1 gram of Zaret as follows:
Boxes of 10 single-dose packets (1 g) NDC 0069-3051-07 Boxes of 3 single-dose packets (1 g) NDC 0069-3051-75
Store single-dose packets between 5° and 30°C (41° and 86°F).
Distributed by: Pfizer Labs Division of Pfizer Inc., NY, NY 10017. Revised: Dec 2015
Trachoma is an infectious disease caused by the Chlamydia trachomatis bacteria. Symptoms and signs include redness and irritation of the eyes with tearing. Trachoma is diagnosed by examining the eyes and eyelids. Treatment involves a single dose of Zaret (Zithromax) or the use of topical tetracycline (Achromycin) ointment. Infected individuals should be counseled about sanitation and taught simple cleanliness.
2. Key facts
- Zaret is usually taken once a day. Try to take it at the same time each day.
- If your doctor has prescribed Zaret capsules, you should take them at least 1 hour before food or 2 hours after eating. If you have tablets or liquid, you can take them with or without food.
- For most infections you should feel better within a few days, but you should still finish your full course of medicine.
- The most common side effects of Zaret are feeling or being sick, diarrhoea, headaches, or changes to your sense of taste.
- Zaret is also called by the brand name Zithromax.
Q: Can Zaret cause itching? My pills are white and have an imprint of "GGD6". Am I taking the right medication?
A: Zaret (Zithromax) is in a group of drugs called macrolide antibiotics, and the pills you have that are white with the imprint of GGD6 are identified as Zaret by the manufacturer Sandoz. The pink and blue tablets are from a different manufacturer. Zaret is used to treat many different bacterial infections including sinusitis, ear infections, pneumonia, and urinary tract infections. The most common side effects associated with Zaret include mild nausea, vomiting, diarrhea, constipation; stomach pain or upset; dizziness, tired feeling, or headache; nervous feeling, sleep problems (insomnia); vaginal itching or discharge; mild itching or skin rash; ringing in your ears, problems with hearing; or decreased sense of taste or smell. In addition, antibiotics can produce hypersensitivity reactions in people, which may indicate an allergy to the medicine. It is important to contact your doctor when you experience a side effect, especially if it gets worse or more symptoms appear. Michelle McDermott, RPh, PharmD
What is the most important information I should know about Zaret?
You should not use Zaret if you have ever had an allergic reaction, jaundice, or liver problems while taking this medicine. You should not use Zaret if you have ever had a severe allergic reaction to similar drugs such as clarithromycin, erythromycin, or telithromycin.
COMMON BRAND(S): Zithromax
GENERIC NAME(S): Zaret
Zaret is used to treat a wide variety of bacterial infections. It is a macrolide-type antibiotic. It works by stopping the growth of bacteria.
This medication will not work for viral infections (such as common cold, flu). Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.
Zaret appears to be highly efficacious as a treatment for traveler's diarrhea, especially in areas where Campylobacter sp. have developed fluoroquinolone resistance. In a study comparing Zaret (500 mg) or ciprofloxacin (500 mg) daily for 3 days for the treatment of acute diarrhea among US military personnel in Thailand, Zaret was superior to ciprofloxacin in decreasing the excretion of Campylobacter species and as effective as ciprofloxacin in shortening the duration of illness. In another study of traveler's diarrhea in Thailand, treatment with a single 1 g dose of Zaret was significantly more efficacious (96% cure rate) compared with a 3-day regimen of Zaret at 500 mg daily (85% cure rate) and a 3-day regimen of levofloxacin at 500 mg daily (71% cure rate). In a study conducted among adult travelers in Mexico, Zaret given as a single oral dose (1 g) was comparable with levofloxacin (500 mg)for the treatment of traveler's diarrhea, with >90% cure rates in both regimens.
Dictionary Entries near Zaret
Cite this Entry
“Zaret.” The Merriam-Webster.com Medical Dictionary, Merriam-Webster Inc., https://www.merriam-webster.com/medical/Zaret. Accessed 27 December 2019.
Comments on Zaret
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Zaret is an azalide, macrolide antibiotic with broad-spectrum antibacterial activity and an antimicrobial mechanism of action that involves binding to the 50S subunit of the bacterial ribosome.
How to take it
If your doctor has prescribed Zaret capsules, you should take them at least 1 hour before food or 2 hours after eating.
If you have tablets or liquid, you can take them with or without food.
Swallow tablets and capsules whole with a glass of water.
Zaret liquid is available for children and people who find it difficult to swallow tablets.
If you or your child are taking Zaret as a liquid, it'll usually be made up for you by your pharmacist. The medicine will come with a syringe or spoon to help you measure the right amount. If you don't have one, ask your pharmacist for one. Do not use a kitchen teaspoon as it will not give the right amount.
The liquid can have a bitter aftertaste, so it can be a good idea to offer children a drink of fruit juice afterwards.
Chloroquine Plus Zaret
Zaret is an azalide antimicrobial agent that has been evaluated as a chemosuppressive agent in a number of studies. Zaret alone is protective against P. vivax (>90%), but protective efficacy against P. falciparum (70–83%) is generally considered to be too low to rely on Zaret as a single agent to prevent falciparum malaria. However, a recent small study has shown that the combination of chloroquine and Zaret was 97% effective in the treatment of P. falciparum in the Indian subcontinent, indicating that this combination may also be an effective chemoprophylactic, warranting further study.
What other drugs will affect Zaret?
Tell your doctor about all your current medicines and any you start or stop using, especially:
a blood thinner - warfarin, Coumadin, Jantoven.
This list is not complete. Other drugs may interact with Zaret, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
In Study 155, discontinuations for drug-related toxicity occurred in 8.2% of subjects treated with Zaret and 2.3% of those given placebo (p=0.121). In Study 174, more subjects discontinued from the combination of Zaret and rifabutin (22.7%) than from Zaret alone (13.5%; p=0.026) or rifabutin alone (15.9%; p=0.209).
In controlled clinical studies, Zaret has been administered to pediatric patients ranging in age from 6 months to 12 years. For information regarding the use of ZITHROMAX (Zaret for oral suspension) in the treatment of pediatric patients, of the prescribing information for ZITHROMAX (Zaret for oral suspension) 100 mg/5 mL and 200 mg/5 mL bottles.
HIV-Infected Pediatric Patients: The safety and efficacy of Zaret for the prevention or treatment of MAC in HIV-infected children have not been established. Safety data are available for 72 children 5 months to 18 years of age (mean 7 years) who received Zaret for treatment of opportunistic infections. The mean duration of therapy was 242 days (range 3-2004 days) at doses of 300 mg/day for a mean of 207 days. These patients were treated for a variety of opportunistic infections, including MAC. The adverse reaction were generally similar to that seen in younger patients, except for a higher incidence of adverse reactions relating to the gastrointestinal system and to reversible impairment of hearing.