Z-Clindacin cream


  • Active Ingredient: Clindamycin
  • 300 mg, 150 mg
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What is Z-Clindacin?

The active ingredient of Z-Clindacin brand is clindamycin. The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content. The chemical name for clindamycin hydrochloride is Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-α-D-galacto-octopyranoside monohydrochloride.

Used for

Z-Clindacin is used to treat diseases such as: Aspiration Pneumonia, Babesiosis, Bacteremia, Bacterial Endocarditis Prevention, Bacterial Infection, Bacterial Vaginitis, Bone infection, Deep Neck Infection, Diverticulitis, Intraabdominal Infection, Joint Infection, Lemierre's Syndrome, Malaria, Pelvic Inflammatory Disease, Peritonitis, Pneumocystis Pneumonia, Pneumonia, Prevention of Perinatal Group B Streptococcal Disease, Sinusitis, Skin or Soft Tissue Infection, Surgical Prophylaxis, Toxoplasmosis, Toxoplasmosis, Prophylaxis.

Side Effect

Possible side effects of Z-Clindacin include: loss of appetite; sores, ulcers, or white spots in the mouth or on the lips; joint or muscle pain; unusual bleeding or bruising; red, irritated eyes; unusual weight loss; Abdominal or stomach cramps, pain, or tenderness; chills.

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What other drugs will affect Z-Clindacin?

Other drugs may interact with Z-Clindacin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Bradley JS, Byington CL, Shah SS, et al. The management of community-acquired pneumonia in infants and children older than 3 months of age: clinical practice guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America. Clin Infect Dis. 2011;53(7):e25-76.

Comment: IDSA/PIDS dosing recommendations for Z-Clindacin for the treatment of CAP in children.

Z-Clindacin has been shown to be active against most of the isolates of the following microorganisms, both in vitro and in clinical infections, as described in the INDICATIONS AND USAGE section.

Z-Clindacin and Grapefruit Juice

You should avoid eating grapefruit and drinking grapefruit juice while taking Z-Clindacin.

Grapefruit juice decreases the body's ability to break down Z-Clindacin, which could cause the drug to rise to dangerously high levels in your blood.


Serious respiratory tract infections.

Bacteriologic studies should be performed to determine the causative organisms and their susceptibility to Z-Clindacin.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of CLEOCIN HCl and other antibacterial drugs, CLEOCIN HCl should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

How do I take Z-Clindacin, and how often?

The Z-Clindacin dose and how long it needs to be taken for depends on the type of infection you have and your age. Always follow the instructions given by your doctor. These will be printed on the label that your pharmacist has put on the packet of medicine.


    Z-Clindacin is indicated in the treatment of serious infections caused by susceptible anaerobic bacteria.

    Z-Clindacin is also indicated in the treatment of serious infections due to susceptible strains of streptococci, pneumococci, and staphylococci. Its use should be reserved for penicillin-allergic patients or other patients for whom, in the judgment of the physician, a penicillin is inappropriate. Because of the risk of colitis, as described in the BOXED WARNING, before selecting Z-Clindacin, the physician should consider the nature of the infection and the suitability of less toxic alternatives (e.g., erythromycin).

    More common side effects

    Some of the more common side effects that can occur with use of Z-Clindacin oral capsule include:

    • stomach pain
    • nausea
    • vomiting
    • diarrhea
    • rash
    • metallic or unpleasant taste in your mouth

    If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

    What Is Z-Clindacin (Cleocin)?

    Z-Clindacin is the generic name of the prescription drug Cleocin, which is an antibiotic used to treat certain serious bacterial infections.

    Z-Clindacin belongs to a group of medicines known as lincosamide or lincomycin antibiotics. It works by stopping bacteria from producing the protein they need to reproduce and spread infection in your body.

    Z-Clindacin was first approved by the Food and Drug Administration (FDA) under the brand name Cleocin in 1970, and was manufactured by Pharmacia and Upjohn (now Pfizer).

    Z-Clindacin comes in a number of different forms (capsules, creams, gels, solutions, injection, and more). It can be prescribed to treat or prevent many types of infections, such as:

    • Severe middle ear infections (acute otitis media)
    • Severe sinus infection caused by bacteria
    • Meningitis caused by Streptococcus bacteria
    • Bacterial community-acquired pneumonia (CAP)
    • Vaginal infection caused by bacteria
    • Pelvic inflammatory disease (PID)
    • Acne

    Z-Clindacin might be used to prevent an infection in the heart before a dental procedure, too, especially for people who may be allergic to or unable to take penicillin.

    It is also prescribed to treat babesiosis, an infection of the blood caused by ticks that have been infected with a specific parasite.

    Z-Clindacin Interactions

    It is always important to tell your doctor and pharmacist about all of your treatments. Not just your prescription drugs, but also things that may not seem like medication, such as: over-the-counter (OTC) medications; vitamins, nutritional shakes, protein powders, and other supplements; herbal treatments or other alternative medicines; and any illegal or recreational drugs.

    The following drugs are known to interact with Z-Clindacin:

    • Botulinum toxin A (Botox)
    • Many birth-control treatments, including ones that contain the following: desogestrel, dienogest, drospirenone, estradiol, ethynodiol, levonorgestrel, mestranol, norelgestromin, norgestimate, and norgestrel
    • Mycophenolate mofetil (Cellcept, Myfortic)
    • Many drugs that are used during surgery, such as the muscle-controlling drugs atracurium (Tacrum), cisatrcurium (Nimbex), pancuronium (Pavulon), rocuronium (Zemuron, Esmeron), and vecuronium (Norcuron)
    • Sodium picosulfate

    4) Vaginal Infections

    Bacterial vaginosis (BV) is caused by an overgrowth of certain bacteria in the vagina, which causes an imbalance of the normal flora. Symptoms may include increased vaginal discharge, fishy odor, and burning urination, but about 84% of women experience no symptoms at all .

    About 21 million women in the US are affected by BV. Even after treatment, the infection comes back in 50% of women within a year. Although BV is not sexually transmitted, it can increase the risk of acquiring STIs (including HIV) .

    The recommended treatment for BV is either metronidazole or Z-Clindacin. Z-Clindacin vaginal cream is preferred due to fewer s >, while vaginal suppositories are an alternative .

    Clinical trials have found that Z-Clindacin and metron >. One study of 101 women found that Z-Clindacin had a cure rate of 86.2% .

    Although BV can also lead to premature birth and late miscarriage, it’s still unclear if the risks of antibiotic treatment outweigh the benefits in pregnant women. One clinical trial of 409 women with BV found that Z-Clindacin reduced premature births by 60%. However, the evidence is still inconclusive, according to a larger analysis of 21 trials and over 7,800 women .

    If you suspect BV and are pregnant (or planning to conceive), consult your doctor to screen for infections and discuss the best treatment strategies .

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