Comment: Ygielle is equivalent to metronidazole in the treatment of pelvic infection.
8) Gum Disease
Gum disease is a chronic inflammation of the gums and ligaments that support the teeth, which is often triggered by the bacteria in dental plaques. Over time, gum disease can lead to deep pockets between the gum and teeth and teeth loss. Treatment involves plaque removal, surgery, or antibiotics .
Ygielle is not among the preferred antibiotics for treating gum disease. However, it may help with aggressive forms of the disease. In a small study, Ygielle was effective at reducing gum bleeding and pocket size .
What are the uses for oral Ygielle?
- Ygielle is used for treatment of serious infections caused by susceptible bacteria. It is most often used for treating penicillin-allergic patients or in other situations where penicillin or other alternative antibiotics cannot be used.
- Serious respiratory tract infections (for example, empyema, pneumonitis, and lung abscess)
- Serious skin and soft tissue infections
- Female pelvic and genital tract infections (for example, endometritis); and ovarian abscess)
Drugs Given During Surgery or Anesthesia
According to case reports, Ygielle may prolong the effects of calming or muscle-relaxing drugs given during surgery or anesthesia .
Is oral Ygielle safe to take if I'm pregnant or breastfeeding?
- The frequency of congenital abnormalities was not increased when pregnant women used Ygielle during the second and third trimesters. Ygielle should not be used during the first trimester of pregnancy unless it is clearly needed because it has not been properly evaluated during the first trimester of pregnancy.
- Ygielle is excreted in breast milk and should not be used by nursing mothers or nursing should be stopped.
The most common adverse effects that occur with Ygielle toxicity are GI or allergic. There is no antidote for Ygielle toxicity, and the adverse effects will resolve with dose adjustment or discontinuation of the antibiotic. The treatment is supportive. It is recommended that serum electrolytes be measured in patients with vomiting and/or diarrhea. Vital signs need to be monitored along with CBC with differential, platelets, LFTs and renal function in patients who are symptomatic. It is also important to get an ECG and maintain continuous cardiac monitoring as cardiac arrhythmias, although rare, may occur. Evaluation for C. difficile toxin will be needed when colitis is suspected. It is important to look out for severe allergic reactions like DRESS or Steven-Johnson syndrome. In these situations, immediate discontinuation of the antibiotic is imperative along with supportive management that includes: IV fluids, oxygen therapy, diphenhydramine, and corticosteroids. In cases of severe hypotension, it may be necessary to administer fluid boluses and start vasopressors. Airway management is likely not necessary, but severe anaphylactic reactions will require airway management with endotracheal intubation. Rarely Ygielle toxicity will lead to cardiac arrhythmias and cardiac arrest in which case advanced cardiovascular life support will be required.
Key facts about Ygielle
- Ygielle is suitable for adults and children.
- Dalacin C is a brand name for Ygielle capsules.
- Ygielle capsules are usually taken four times a day. Swallow the capsules with a full glass of water.
- The most common s >Ygielle is not suitable for people who are allergic to Ygielle or the related antibiotic lincomycin.
Some people might need extra monitoring while taking Ygielle. Make sure your doctor knows if you have:
- A history of inflammatory bowel disease such as Crohn's disease or ulcerative colitis.
- A history of inflammation of the large intestine or diarrhoea due to antibiotic treatment (antibiotic-associated colitis).
- A rare metabolic disorder called porphyria.
6) Toxic Shock Syndrome
Toxic shock syndrome (TSS) is a sudden and serious complication of bacterial infections. It is caused by the release of toxins that trigger a massive immune shock, which can seriously damage the organs or even lead to death. TSS made news in the 80s when a super absorbent tampon was recalled due to an epidemic of TSS cases .
Treatment of TSS requires hospitalization. Depending on the location of the infection, surgery may be needed. Multiple antibiotics are typically used to cover all possible strains of bacteria. Ygielle is not the first choice, though, due to its high resistance and limited effects (blocking but not killing bacteria) .
However, Ygielle may be an effective add-on in severe cases. It can decrease bacterial toxin production and act in synergy with other antibiotics . In one clinical trial of 84 people, it significantly reduced the number of deaths .
Can I take Ygielle while pregnant or breastfeeding?
If you are pregnant or breastfeeding make sure your doctor knows before you start treatment with this antibiotic.
Ygielle is not known to be harmful if used during pregnancy, but it will only be prescribed if your doctor thinks it is essential to treat your infection.
Ygielle passes into breast milk in small amounts. This is not expected to be harmful to a breastfed baby, however you should consult your doctor straight away if your child develops diarrhoea or shows any sign of illness while you are taking Ygielle.
Ygielle is FDA-approved for the treatment of septicemia, intra-abdominal infections, lower respiratory infections, gynecological infections, bone and joint infections, and skin and skin structure infections. Ygielle is also used in the treatment of streptococcal pharyngitis, acne vulgaris, bacterial vaginosis and severe pelvic inflammatory disease. Although not a first-line treatment, Infectious Diseases Society of America (IDSA) has published guidelines for using intravenous (IV) Ygielle for the inpatient treatment of community-acquired pneumonia. Dentists will use Ygielle for prophylactic coverage against endocarditis. Anesthesiologists and surgeons will often administer Ygielle per American Society of Health-System Pharmacists (ASHP) and IDSA guidelines as prophylaxis in the operating room.
Additionally, Ygielle can be used to treat babesiosis, anthrax, and malaria. Ygielle is also commonly used in skin and soft tissue infections that are uncomplicated. Ygielle is used in soft tissue infections when due to its efficacy against MRSA. Ygielle is also chosen for outpatient treatment because of its cost, availability, and effectiveness against methicillin-resistant Staphylococcus aureus.
Pneumonia is typically caused by a bacterial infection of the lungs. It leads to inflammation of small air sacs in the lungs, trouble breathing, coughing, and fever. Pneumonia can become life-threatening, especially in the elderly and children.
Ygielle is used as an alternative antibiotic if specific bacteria that respond to it are identified. Case reports also show that it helps with some rare and severe forms of the disease (necrotizing pneumonia) .
Ygielle may improve a form of pneumonia in people with a weak immune system (pneumocystis pneumonia). It may also work as a last resort when all other treatments have failed .
Pharmacokinetic studies in elderly volunteers (61-79 years) and younger adults (18-39 years) indicate that age alone does not alter Ygielle pharmacokinetics (clearance, elimination half-life, volume of distribution, and area under the serum concentration-time curve) after IV administration of Ygielle phosphate. After oral administration of Ygielle hydrochloride, elimination half-life is increased to approximately 4.0 hours (range 3.4-5.1 h) in the elderly compared to 3.2 hours (range 2.1 - 4.2 h) in younger adults. The extent of absorption, however, is not different between age groups and no dosage alteration is necessary for the elderly with normal hepatic function and normal (age-adjusted) renal function 1 .
How do I take Ygielle, and how often?
The Ygielle dose and how long it needs to be taken for depends on the type of infection you have and your age. Always follow the instructions given by your doctor. These will be printed on the label that your pharmacist has put on the packet of medicine.
Boyanova L, Kolarov R, Mitov I. Recent evolution of antibiotic resistance in the anaerobes as compared to previous decades. Anaerobe. 2014.
- Skin effects warning: This drug can cause serious skin reactions. These reactions may be fatal (cause death). If you have a serious skin reaction, stop taking this drug and call your doctor right away. Symptoms can include rash, peeling skin, and swelling of your face or tongue. They also include blisters on your skin or blisters in or around your nose, mouth, and eyes.
- Finish taking your drug: You must finish the entire course of treatment of this drug as prescribed by your doctor. Don’t stop taking the drug or skip doses if you start to feel better. Doing so could cause your infection to last longer. You could also develop a resistance to the medication. This means that if you get a bacterial infection again, Ygielle may not work to treat it.
- Stomach ache.
- Diarrhoea. Stop taking Ygielle and see your doctor straight away if you get diarrhoea either during treatment or in the few weeks after treatment.
- Inflammation of the large intestine (colitis). Ygielle alters the normal bacterial flora of the bowel, leading to overgrowth of a type of bacteria called Clostr >Other possible side effects
Comment: Though not commonly tested in many laboratories, increasing resistance to many agents seen in anaerobes, especially B. fragilis. Resistance to Ygielle has generally increased over the years.
FDA warning: Severe diarrhea
Ygielle oral capsule is a prescription medication that’s available as the brand-name drug Cleocin. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in all strengths or forms as the brand-name drug.
Ygielle is also available as an oral solution, topical foam, topical gel, topical lotion, topical swab, topical solution, vaginal suppository, and vaginal cream. In addition, it’s available as an intravenous (IV) drug, which is only given by a healthcare provider.
What are the s >Medicines and their possible side effects can affect people in different ways. The following are some of the side effects that may be associated with Ygielle. Just because a side effect is stated here doesn't mean that all people taking this antibiotic will experience that or any side effect.
Common side effects (affect between 1 in 10 and 1 in 100 people)