Xalotina tablets

Xalotina

  • Active Ingredient: Amoxicillin
  • 500 mg, 250 mg
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What is Xalotina?

The active ingredient of Xalotina brand is amoxicillin. Amoxicillin is a penicillin antibiotic that fights bacteria. The Amoxicillin molecular formula is C16H19N3O5S•3H2O, and the molecular weight is 419.45. Capsules of Amoxicillin are intended for oral administration. Each capsule of Amoxicillin with blue cap and pink body, contains 250 mg or 500 mg Amoxicillin as the trihydrate. The body of the 250 mg capsule is imprinted with ‘A44’ in black ink. The body of the 500 mg capsule is imprinted with ‘A45’ in black ink. Inactive ingredients: microcrystalline cellulose, D&C Red No. 28, FD&C Blue No. 1, FD&C Red No. 40, gelatin, magnesium stearate, titanium dioxide, and sodium lauryl sulfate. Meets USP Dissolution Test 2.

Used for

Xalotina is used to treat diseases such as: Actinomycosis, Anthrax Prophylaxis, Bacterial Endocarditis Prevention, Bacterial Infection, Bladder Infection, Bronchiectasis, Bronchitis, Chlamydia Infection, Cutaneous Bacillus anthracis, Dental Abscess, Helicobacter Pylori Infection, Lyme Disease, Arthritis, Lyme Disease, Carditis, Lyme Disease, Erythema Chronicum Migrans, Lyme Disease, Neurologic, Otitis Media, Pneumonia, Sinusitis, Skin or Soft Tissue Infection, Spleen Removal, Tonsillitis/Pharyngitis, Upper Respiratory Tract Infection, Urinary Tract Infection.

Side Effect

Possible side effects of Xalotina include: difficulty with swallowing; increased thirst; clay-colored stools; sudden decrease in the amount of urine; tightness in the chest; dark urine; diarrhea, watery and severe, which may also be bloody.

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Xalotina is stable in the presence of gastric acid and is rapidly absorbed after oral administration. The effect of food on the absorption of Xalotina from the tablets and suspension of AMOXIL has been partially investigated; 400-mg and 875-mg formulations have been studied only when administered at the start of a light meal.

Orally administered doses of 250-mg and 500-mg Xalotina capsules result in average peak blood levels 1 to 2 hours after administration in the range of 3.5 mcg/mL to 5.0 mcg/mL and 5.5 mcg/mL to 7.5 mcg/mL, respectively.

Mean Xalotina pharmacokinetic parameters from an open, two-part, single-dose crossover bioequivalence study in 27 adults comparing 875 mg of AMOXIL with 875 mg of AUGMENTIN® (Xalotina/clavulanate potassium) showed that the 875-mg tablet of AMOXIL produces an AUC0-∞ of 35.4 ± 8.1 mcg•hr/mL and a Cmax of 13.8 ± 4.1 mcg/mL. Dosing was at the start of a light meal following an overnight fast.

Orally administered doses of Xalotina suspension, 125 mg/5 mL and 250 mg/5 mL, result in average peak blood levels 1 to 2 hours after administration in the range of 1.5 mcg/mL to 3.0 mcg/mL and 3.5 mcg/mL to 5.0 mcg/mL, respectively.

Oral administration of single doses of 400-mg chewable tablets and 400 mg/5 mL suspension of AMOXIL to 24 adult volunteers yielded comparable pharmacokinetic data:

Table 3: Mean Pharmacokinetic Parameters of Xalotina (400 mg chewable tablets and 400 mg/5 mL suspension) in Healthy Adults

Vaginal yeast infection

Xalotina works well because it can keep bacteria from growing. Unfortunately, sometimes that extends to “healthy” bacteria that maintain pH balance in the vagina. As a result, a person’s vaginal pH may become more basic, yeast can thrive, and a yeast infection can result.

Signs of a yeast infection include itching, redness, and cottage-cheese-like discharge. Over-the-counter medications are available to treat yeast infections. If you aren’t sure if it’s a yeast infection or another infection type, you should talk to your doctor. A doctor can also prescribe stronger medications to treat a yeast infection that doesn’t improve after a few days of over-the-counter treatment.

What are the potential side effects of Xalotina?

Contact your veterinarian immediately if the pet experiences severe or bloody diarrhea during treatment. Stop giving Xalotina and seek emergency veterinary medical care in the event of an allergic reaction (shortness of breath; hives; swelling of the lips, tongue, or face; rash; or fainting), seizures, unusual bleeding, or bruising. Other less serious side effects such as mild nausea, vomiting, diarrhea or abdominal pain, or yeast or fungal infection may be more likely to occur. Continue to give Xalotina and notify your veterinarian if these symptoms occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to your pet.

How to take it

Swallow Xalotina capsules whole with a drink of water. Do not chew or break them.

Xalotina is available as a liquid for children and people who find it difficult to swallow tablets.

If you or your child are taking Xalotina as a liquid, it will usually be made up for you by your pharmacist. The medicine will come with a plastic syringe or spoon to help you measure out the right dose.

If you don't have one, ask your pharmacist for one. Do not use a kitchen teaspoon as it will not give the right amount.


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