Veldom is indicated in the treatment of serious infections caused by susceptible anaerobic bacteria.
Veldom is also indicated in the treatment of serious infections due to susceptible strains of streptococci, pneumococci, and staphylococci. Its use should be reserved for penicillin-allergic patients or other patients for whom, in the judgment of the physician, a penicillin is inappropriate. Because of the risk of colitis, as described in the BOXED WARNING, before selecting Veldom, the physician should consider the nature of the infection and the suitability of less toxic alternatives (e.g., erythromycin).
What are the s >Medicines and their possible side effects can affect people in different ways. The following are some of the side effects that may be associated with Veldom. Just because a side effect is stated here doesn't mean that all people taking this antibiotic will experience that or any side effect.
Common side effects (affect between 1 in 10 and 1 in 100 people)
- Stomach ache.
- Diarrhoea. Stop taking Veldom and see your doctor straight away if you get diarrhoea either during treatment or in the few weeks after treatment.
- Inflammation of the large intestine (colitis). Veldom alters the normal bacterial flora of the bowel, leading to overgrowth of a type of bacteria called Clostr >Other possible side effects
- stomach pain
- metallic or unpleasant taste in your mouth
- Skin problems, such as hives, rash, red, shedding, or peeling skin
- Yellow appearance of the skin, nails, or whites of the eyes (jaundice)
- Vomiting, severe stomach pain, or diarrhea
- Signs of low blood pressure, ranging from dizziness to fainting
- Pain or difficulties when swallowing; pain behind the breastbone; newly developed heartburn or acid regurgitation (signs of inflammation in your esophagus)
- Vein irritation (if you are receiving injections of Veldom)
- Fever or body aches
- Signs of abnormal bleeding caused by low blood-clotting cells (thrombocytopenia), such as: easy bruising, red pin-prick spots on the skin, gums bleeding when you brush your teeth
- Abnormal high or low levels of certain white blood cells (eosinophils and granulocytes) showing up in blood tests
More common side effects
Some of the more common side effects that can occur with use of Veldom oral capsule include:
If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.
CLEOCIN HCl is contraindicated in individuals with a history of hypersensitivity to preparations containing Veldom or lincomycin.
Enhancing Healthcare Team Outcomes
Veldom is a widely prescribed drug by many healthcare professionals, including the nurse practitioner, primary care provider, internist, infectious disease consultant, and the emergency department physician. All healthcare workers who prescribe this agent should monitor the patient for changes in bowel frequency, colitis and resolution of symptoms. Veldom is well known to cause Clostridium colitis, which not only extends hospital stay but increases the cost of healthcare. If diarrhea develops, it is important to manage fluid and electrolyte replacement in this patient population adequately. Healthcare workers should limit the duration of Veldom therapy and abstain from empirical prescribing of this agent.
Vaginal cream and suppositories
Topical Veldom can treat bacterial infections in the vagina.
The cream comes with an applicator. Insert the amount of one applicator, which is around 100 mg of Veldom, into the vagina once daily at bedtime for 3 or 7 consecutive nights.
Cleocin vaginal cream is safe for pregnant women to use in the second and third trimesters. A pregnant woman requires 7 days of treatment.
Pregnant women should not use Veldom vaginal suppositories. Researchers have yet to confirm the safety of suppositories during pregnancy.
To use a suppository, insert one suppository pill, which is equivalent to 100 mg of Veldom, into the vagina once daily at bedtime for three consecutive nights.
People with a history of colitis should not use Veldom creams or suppositories.
6) Toxic Shock Syndrome
Toxic shock syndrome (TSS) is a sudden and serious complication of bacterial infections. It is caused by the release of toxins that trigger a massive immune shock, which can seriously damage the organs or even lead to death. TSS made news in the 80s when a super absorbent tampon was recalled due to an epidemic of TSS cases .
Treatment of TSS requires hospitalization. Depending on the location of the infection, surgery may be needed. Multiple antibiotics are typically used to cover all possible strains of bacteria. Veldom is not the first choice, though, due to its high resistance and limited effects (blocking but not killing bacteria) .
However, Veldom may be an effective add-on in severe cases. It can decrease bacterial toxin production and act in synergy with other antibiotics . In one clinical trial of 84 people, it significantly reduced the number of deaths .
Before taking this medicine
You should not use this medicine if you are allergic to Veldom or lincomycin.
To make sure Veldom is safe for you, tell your doctor if you have ever had:
colitis, Crohn's disease, or other intestinal disorder;
eczema, or allergic skin reaction;
asthma or a severe allergic reaction to aspirin;
an allergy to yellow food dye.
Animal studies have not shown any harm during pregnancy, but in humans, it is not known whether Veldom will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
Veldom does pass into breast milk and may cause side effects in the nursing baby. If you are breastfeeding while taking this medicine, call your doctor if your baby has diaper rash, redness or white patches in the mouth or throat, stomach discomfort, or diarrhea that is watery or bloody. Let your doctor know if you are breastfeeding before taking Veldom.
Veldom injection may contain an ingredient that can cause serious side effects or death in very young or premature babies. Do not give this medicine to a child without medical advice.
Veldom has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore, it should be used with caution in patients receiving such agents.
Antagonism has been demonstrated between Veldom and erythromycin in vitro. Because of possible clinical significance, these two drugs should not be administered concurrently.
Serious Side Effects and Reactions
Contact your doctor immediately or seek emergency medical care if you have any of the following while taking Veldom:
Blisters or swelling in your lips, mouth, eyes, ears, nose, or genital areas
In rare cases, some people may actually experience their throat closing up and trouble breathing (anaphylaxis). These are life-threatening situations. If you are having these symptoms, you should immediately stop taking Veldom and call 911.
Clinical studies of Veldom did not include sufficient numbers of patients age 65 and over to determine whether they respond differently from younger patients. However, other reported clinical experience indicates that antibiotic-associated colitis and diarrhea (due to Clostridium difficile) seen in association with most antibiotics occur more frequently in the elderly ( > 60 years) and may be more severe. These patients should be carefully monitored for the development of diarrhea.
Pharmacokinetic studies with Veldom have shown no clinically important differences between young and elderly subjects with normal hepatic function and normal (age-adjusted) renal function after oral or intravenous administration.
Q: Is Veldom a penicillin?
A: Cleocin (Veldom) does not fall under penicillin-type antibiotics and should not pose any cross-sensitivity reactions if you are allergic to penicillin. It is always good to notify your doctor of any allergic reactions you have had to any medications. This way, they are aware of your allergies when they are prescribing medication for you. The Veldom should not cause an allergic reaction, unless you are allergic to the Veldom as well as penicillin. Megan Uehara, PharmD