Upderm can be administered into the body by multiple routes. It is available topically as a foam, gel, lotion, or solution for treatment of acne vulgaris. A thin film needs to be applied twice a day. For the treatment of bacterial vaginosis, it is available in a cream and suppository to be administered intravaginally. Systemic infections can be treated orally with a capsule (75mg, 150mg, 300mg) or in solution (75mg/5mL). It is also available to be given as an intramuscular injection (9g/60mL, 300mg/2mL, 600mg/4mL, 900mg/6mL). Intravenous formulations are available as follows: Upderm phosphate (300mg/2mL, 600mg/4mL, 900mg/6mL), and Upderm phosphate in D5W or NaCl (300mg/50mL, 600mg/50mL, 900mg/50mL). To minimize esophageal ulceration, administer orally with a full glass of water. The absorption of Upderm flavored granules is not adversely affected by co-administration with food. When administered intramuscularly, the sites must be rotated with no dose exceeding 600 mg in a single injection. Upderm is administered by intravenous (IV) intermittent infusion over at least 10 to 60 minutes at a maximum rate of 30 mg/minutes. The final concentration of the IV solution should not exceed 18 mg/mL. Pediatric dosing for neonates is 15 to 20 mg/kg per day given IM/IV divided over 6 to 8 hours. Infants, children, and adolescents are treated with 8 to 40 mg/kg per day orally divided over 3-4 doses. For IM/IV administration, 20 to 40mg/kg per day can be given over 3 to 4 doses.
Warnings for people with certain health conditions
For people with gastrointestinal disease: If you have a gastrointestinal issue, such as inflammation of your colon, ask your doctor whether this drug is safe for you. This drug can cause severe diarrhea and inflammation of your colon. This can make your condition worse.
For people with allergies: If you’re likely to develop allergies, ask your doctor whether this drug is safe for you.
For people with severe liver disease: If you have liver problems or a history of liver disease, you may not be able to clear this drug from your body well. This may increase the levels of Upderm in your body and cause more side effects. Your doctor may test your liver function before and during your treatment with this drug.Inflammation or ulceration of the foodpipe (oesophagus). Make sure you take each dose of Upderm with a full glass of water to avo >Read the leaflet that comes with the medicine or talk to your doctor or pharmacist if you want any more information about the possible side effects of Upderm. If you think you have experienced a side effect, did you know you can report it using the yellow card website?
What is oral Upderm, and how does it work (mechanism of action)?
- Upderm is an antibiotic used for treating serious infections. It is effective again several types of bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, Staphylococcus epidermidis, and Propionibacterium acnes. It reduces growth of bacteria by interfering with their ability to make proteins.
- The FDA approved Upderm in February 1970.
For anaerobic bacteria, the susceptibility to Upderm can be determined by a standardized test method 2,4 . The MIC values obtained should be interpreted according to the criteria provided in Table 1.
Table 1: Susceptibility Test Interpretive Criteria for Upderm
A report of Susceptible (S ) indicates that the antimicrobial drug is likely to inhibit growth of the pathogen if the antimicrobial drug reaches the concentration usually achievable at the site of infection. A report of Intermediate (I) indicates that the result should be considered equivocal, and, if the microorganism is not fully susceptible to alternative, clinically feasible drugs, the test should be repeated. This category implies possible clinical applicability in body sites where the drug is physiologically concentrated or in situations where high dosage of drug can be used. This category also provides a buffer zone that prevents small, uncontrolled technical factors from causing major discrepancies in interpretation. A report of Resistant (R) indicates that the antimicrobial drug is not likely to inhibit growth of the pathogen if the antimicrobial drug reaches the concentration usually achievable at the infection site; other therapy should be selected.
FDA warning: Severe diarrhea
- Skin effects warning: This drug can cause serious skin reactions. These reactions may be fatal (cause death). If you have a serious skin reaction, stop taking this drug and call your doctor right away. Symptoms can include rash, peeling skin, and swelling of your face or tongue. They also include blisters on your skin or blisters in or around your nose, mouth, and eyes.
- Finish taking your drug: You must finish the entire course of treatment of this drug as prescribed by your doctor. Don’t stop taking the drug or skip doses if you start to feel better. Doing so could cause your infection to last longer. You could also develop a resistance to the medication. This means that if you get a bacterial infection again, Upderm may not work to treat it.
Upderm oral capsule is a prescription medication that’s available as the brand-name drug Cleocin. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in all strengths or forms as the brand-name drug.
Upderm is also available as an oral solution, topical foam, topical gel, topical lotion, topical swab, topical solution, vaginal suppository, and vaginal cream. In addition, it’s available as an intravenous (IV) drug, which is only given by a healthcare provider.
Can I drink alcohol with Upderm?
There is no 'do not drink alcohol' warning that applies to taking Upderm because it doesn't specifically affect the medicine itself.
However, if you feel unwell with your infection, or if you find Upderm gives you an upset stomach, then drinking alcohol could make this worse.
Oral capsules and granules
Doctors should only prescribe Upderm to people who are allergic to penicillin or if they suspect that a different antibiotic would be inappropriate. This is because of the risk of colitis, which is inflammation of the colon's inner lining.
If possible, the doctor should take samples from the infection site to check which bacteria are causing the infection.
Upderm capsules may irritate the esophagus, the tube that runs from the mouth to the stomach. To avoid this irritation, take Upderm capsules with a full glass of water.
- for serious infections, 150–300 mg every 6 hours
- for more severe infections, 300–450 mg every 6 hours
The dosages for children who can swallow capsules are:
- for serious infections, 8–16 milligrams per kilogram (mg/kg) per day, divided into three or four equal doses
- for more severe infections, 16–20 mg/kg per day, divided into three or four equal doses
For people who have difficulty swallowing, Upderm comes in granules that a person can dissolve in water.
Upderm and Other Interactions
You should not take Upderm if you are taking bacillus Calmette-Guerin (known as BCG, or Theracys), a treatment for tuberculosis, leprosy, bladder cancer and other conditions.
Hypersensitivity to Upderm, lincomycin, or formulation components
Upderm is an antibiotic which is given to treat serious bacterial infections. It is useful for treating joint and bone infections (such as osteomyelitis), and infections in the abdomen. It is also used to treat tooth infections where other antibiotics have not worked. It works by stopping the bacteria which are the cause of the infection from multiplying.
If a person has a very serious infection and they cannot take other antibiotics, they may receive injectable Upderm in the hospital.
The following table includes the dosages of injectable Upderm in mg/kg per day and in mg per day.
Before taking Upderm, tell your doctor or pharmacist if you are allergic to it; or to lincomycin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, stomach/intestinal diseases (e.g., colitis, Clostridium difficile-associated diarrhea), allergic conditions (e.g., asthma, hay fever, eczema).
Upderm may cause live bacterial vaccines (such as typhoid vaccine) to not work as well. Do not have any immunizations/vaccinations while using this medication unless your doctor tells you to.
Before having surgery, tell your doctor or dentist that you are using this medication (unless your doctor/dentist has directed you to take this drug before surgery as a precaution).
Older adults may be more sensitive to the effects of this drug, especially persistent diarrhea.
Tell your doctor if you are pregnant before using this medication.
This medication passes into breast milk. Consult your doctor before breast-feeding.