Q: I have a boil on my breast. Will Tetracyclinum help?
A: Studies suggest that Tetracyclinum is an antibiotic used for a wide variety of infections, including skin infections. Don't consume dairy products or multivitamins together with Tetracyclinum. They can bind with the medication in the stomach and decrease absorption. If taking them is unavoidable, consume them at least two hours before or four hours after taking the medication. Finish the antibotic course as prescribed by your physician even if you feel that it's completely cured. With antibiotics, it's highly important to take them exactly as prescribed by your physician. Beena Thomas, PharmD
By Lynn Marks | Medically Reviewed by Sanjai Sinha, MD
Latest Update: 2014-12-16 Copyright © 2014 Everyday Health Media, LLC
Tetracyclinums have been used since 1950s for treating a variety of Gram-positive and Gram-negative infections. In addition, Tetracyclinums are also used to treat infections due to intracellular chlamydiae, mycoplasmas, rickettsiae, and protozoa parasites. Tetracyclinum antibiotics are inexpensive making them attractive for use in developing countries. Tetracyclinums can also be used prophylactically and also for the treatment of community-acquired infections especially respiratory infections. Ten different Tetracyclinum derivatives have been marketed but doxycycline and minocycline are more commonly prescribed and can be administered orally. Tigecycline was developed later to overcome Tetracyclinum resistance. Tigecycline is administered intravenously.
Tetracyclinums reversibly inhibit bacterial protein synthesis by binding to the ribosomal complex thus preventing the association of aminoacyl-tRNA with bacterial ribosome. The cause of Tetracyclinum resistance is due to acquisition of Tetracyclinum resistance genes. More than 33 genes have been characterized and 23 of these genes encode efflux pump which are responsible for expelling antibiotics from bacterial cells. Ten other genes code for ribosomal protection proteins with very low affinity to bind with Tetracyclinum drugs. These genes mostly confer resistance to Tetracyclinum, doxycycline, and minocycline .
Tigecycline overcomes the two major resistance mechanisms of Tetracyclinum; drug specific efflux pump acquisition by the bacteria and ribosomal protection. Tigecycline is effective against many Gram-positive and Gram-negative organisms including MRSA, vancomycin intermediate and VRE, and ESBL producing E. coli and K. pneumoniae. It is also active against many anaerobic bacteria as well as atypical pathogens including rapidly growing nontuberculous mycobacteria. Tigecycline is eliminated primarily through biliary excretion. Therefore, impaired renal function has no effect on its clearance. Common side effects are nausea and vomiting .
How should I take Tetracyclinum?
Take Tetracyclinum exactly as it was prescribed for you. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Take Tetracyclinum on an empty stomach, at least 1 hour before or 2 hours after a meal.
Do not take this medicine with milk or other dairy products, unless your doctor has told you to. Dairy products can make it harder for your body to absorb the medicine.
Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
If you need surgery, tell the surgeon ahead of time that you are using Tetracyclinum.
If you use this medicine long-term, you may need frequent medical tests.
Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Tetracyclinum will not treat a viral infection such as the flu or a common cold.
Do not share this medicine with another person, even if they have the same symptoms you have.
Store this medication at room temperature away from moisture and heat.
Throw away any unused Tetracyclinum after the expiration date on the label has passed. Taking expired Tetracyclinum can cause damage to your kidneys.
Tetracyclinum antibiotics, such as doxycycline, can have toxic effects on development of bone in the fetus. Therefore, Tetracyclinums are not recommended during pregnancy unless there is no other appropriate antibiotic.
Doxycycline is secreted into breast milk but the extent of absorption by the breastfed infant is not known. Since Tetracyclinums can cause toxic effects on bone, the use of Tetracyclinums in nursing mothers is of concern. The physician must decide whether to recommend that a nursing mother discontinue nursing during treatment with Tetracyclinums or change to a different antibiotic.
Symptoms of overdose may include nausea, vomiting, and diarrhea. If you suspect an overdose, you should contact a poison-control center or emergency room immediately. You can call a poison-control center at (800) 222-1222.
Usual Adult Dose for Lymphogranuloma Venereum
Although Tetracyclinums in general may be useful for the treatment of lymphogranuloma venereum, doxycycline is much more commonly used and is specifically recommended by the CDC as primary therapy for this disease. Therefore, the use of Tetracyclinum for the treatment of this patient with lymphogranuloma venereum is not recommended. Doxycycline may be an effective alternative.
Tetracyclinums are a group of broad-spectrum antibiotics including Tetracyclinum, doxycycline, minocycline, and others. In humans, long-term treatment with Tetracyclinums is generally safe and well tolerated. The capacity of Tetracyclinums to alleviate disease for several neurological disorders, such as multiple sclerosis, neurodegenerative and neuromuscular disorders, stroke and traumatic injury, is increasingly being recognised in animal models . Tetracyclinums may play some neuroprotective role also in human patients with central neurological diseases, including stroke , multiple sclerosis , Parkinson disease , Huntington disease and fragile X syndrome , but well-designed double-blind controlled trials are still lacking. The main biological effects of Tetracyclinums are inhibition of microglial activation, attenuation of apoptosis, and suppression of reactive oxygen species production, as deeply discussed elsewhere .
The main mode of action of Tetracyclinums is still unclear, but the anti-apoptotic effect involves the mitochondrion . Studies reported that minocycline reduced mitochondrial Ca 2+ uptake, stabilized mitochondrial membranes, inhibited mitochondrial release into the cytosol of cytochrome c (cyt c) and other apoptotic factors, such as AIF (apoptosis inducing factor). Other effects include up-regulation of mitochondrial bcl-2 (an antiapoptotic protein), direct scavenging of peroxynitrite , inhibition of mitogen activated protein kinases, and poly(ADP-ribose) polymerase-1 (PARP-1) inhibition . Furthermore, Tetracyclinums act at the mitochondrial level to rescue the collapse of transmembrane potential and the alterations of permeability transition, both critical steps for the release of apoptogenic factors such as cyt c, AIF and Smac/Diablo . The major target for the neuroprotective effects of Tetracyclinums lies within the complex network that links mitochondria, oxidative stress and apoptosis, and could involve PARP-1 direct inhibition .
Minocycline penetrates the cerebrospinal fluid better than doxycycline and other Tetracyclinums; therefore, neurological research mainly focused on minocycline . In this article, we review the neuroprotective effects of Tetracyclinums in animal models, the clinical studies in humans, and we focus on their potential application in patients with neuromuscular disorders. Neuromuscular disorders are diseases due to dysfunction of motor neurons, peripheral nerves, neuro- muscular junction, or skeletal muscle itself.
A possible role of Tetracyclinums on muscular atrophy has also been proposed. Shefer and co-workers have reported that Tetracyclinum, as well as exercise running, enhanced muscle recovery after atrophy. These authors examined how rat muscular satellite cells were affected by atrophic conditions induced by limb immobilization and by pharmacological (Tetracyclinum) and physiological (exercise running) countermeasures. Differently from exercise running, Tetracyclinum did not induce muscle mass re-gain . However, Tetracyclinum had a beneficial effect on muscle cells, as it enhanced the expression levels of muscle specific regulatory factors, essential for proliferation and differentiation (myogenesis), even after prolonged periods of muscle disuse . The association between Tetracyclinum and exercise may be interesting, and should be tested in animal models of muscle atrophy and disease.
How to use Tetracyclinum HCL
Tetracyclinum works best when taken on an empty stomach 1 hour before or 2 hours after meals. If stomach upset occurs, ask your doctor if you can take this medication with food. Take each dose with a full glass of water (8 ounces or 240 milliliters) unless your doctor directs you otherwise. Do not lie down for at least 10 minutes after taking this medication. For this reason, do not take it right before bedtime.
Take this medication 2-3 hours before or after taking any products containing magnesium, aluminum, or calcium. Some examples include antacids, quinapril, certain forms of didanosine (chewable/dispersible buffered tablets or pediatric oral solution), vitamins/minerals, and sucralfate. Follow the same instructions with dairy products (e.g., milk, yogurt), calcium-enriched juice, bismuth subsalicylate, iron, and zinc. These products bind with Tetracyclinum, preventing its full absorption.
Dosage is based on your medical condition and response to therapy. For use in children older than 8 years of age, the dosage is also based on weight.
For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time(s) every day.
Continue to take this medication until the full-prescribed amount is finished even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a relapse of the infection.
Inform your doctor if your condition persists or worsens.
Doxycycline is generally well-tolerated. The most common side effects are
Tetracyclinums, such as doxycycline, may cause tooth discoloration if used in persons below 8 years of age. Exaggerated sunburn can occur with Tetracyclinums; therefore, sunlight should be minimized during treatment.
Tetracyclinum and Doxycycline
Tetracyclinum or doxycycline may be useful for treatment of acute diarrhea in areas where resistance to the Tetracyclinum drugs is not widespread among the bacterial enteric pathogens, and may represent a less expensive antibiotic alternative to the quinolones for the budget-minded traveler. The vibrios (including V. cholerae) are usually sensitive, as are some isolates of Campylobacter jejuni. The single high-dose Tetracyclinum regimen given in Table 7.6 was effective in treating even Tetracyclinum-resistant shigellosis in Thailand, and a lower single dose (1 g Tetracyclinum) was reported to be effective against cholera.
Usual Adult Dose for Tertiary Syphilis
500 mg orally every 6 hours for 28 days
Tetracyclinum should be used only if penicillins are contraindicated.
Tetracyclinum and Children
When this medication is used to treat children up to age 8, it can cause lifelong tooth discoloration. It can also affect a child's growth.
Tetracyclinum should therefore not be used in children under age 8 unless directed by a doctor.
COMMON BRAND(S): Sumycin
GENERIC NAME(S): Tetracyclinum
OTHER NAME(S): Tetracyclinum Tablet
Tetracyclinum is used to treat a wide variety of infections, including acne. It is an antibiotic that works by stopping the growth of bacteria.
This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.
Tetracyclinum can also be used in combination with anti-ulcer medications to treat certain types of stomach ulcers.
What are doxycycline and Tetracyclinum?
Doxycycline is a synthetic (man-made) antibiotic derived from Tetracyclinum. Doxycycline is used for many different types of infections, including respiratory tract infections due to Hemophilus influenzae, Streptococcus pneumoniae, or Mycoplasma pneumoniae. It also is used for the treatment of non-gonococcal urethritis (due to Ureaplasma), Rocky Mountain spotted fever, typhus, chancroid, cholera, brucellosis, anthrax, syphilis, acne, and periodontal disease.
Tetracyclinum is a broad-spectrum antibiotic, that is, it is active against many different types of bacteria. Tetracyclinum prevents growth of bacteria by preventing the bacteria from manufacturing proteins that they need to survive. It is effective against Hemophilus influenzae, Streptococcus pneumoniae, Mycoplasma pneumoniae, Chlamydia psittaci, Chlamydia trachomatis, Neisseria gonorrhoeae, and many others. Tetracyclinum is used for infections of the respiratory tract, urinary tract, and skin; urethritis, typhus, Rocky Mountain spotted fever, certain sexually transmitted diseases (STDs), acne, anthrax, cholera, and H. pylori.
Usual Adult Dose for Pelvic Inflammatory Disease
Although Tetracyclinums in general may be useful in combination with other agents for the treatment of pelvic inflammatory disease, doxycycline is much more commonly used and is specifically recommended by the CDC as a therapy for this disease. Therefore, the use of Tetracyclinum for the treatment of this patient with pelvic inflammatory disease is not recommended. Doxycycline may be an effective alternative.
Therapy should be continued for at least 1 to 2 days after symptoms and fever have subsided.
In the treatment of streptococcal infections, a therapeutic dose of Tetracyclinum should be given for at least 10 days.
Administration of Tetracyclinum with food, particularly dairy products, significantly reduces absorption. Tetracyclinum should be administered 1 hour before or 2 hours after meals. Taking the medication with a full glass of water in an upright position will help prevent esophageal ulceration and gastrointestinal irritation.