Taracycline capsules

Taracycline

  • Active Ingredient: Tetracycline
  • 500 mg, 250 mg
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What is Taracycline?

The active ingredient of Taracycline brand is tetracycline. Tetracycline is an antibiotic that fights infection caused by bacteria.

Used for

Taracycline is used to treat diseases such as: Acne, Bacterial Infection, Bladder Infection, Bronchitis, Brucellosis, Bullous Pemphigoid, Chlamydia Infection, Ehrlichiosis, Epididymitis, Sexually Transmitted, Gonococcal Infection, Uncomplicated, Helicobacter Pylori Infection, Lyme Disease, Arthritis, Lyme Disease, Carditis, Lyme Disease, Erythema Chronicum Migrans, Lyme Disease, Neurologic, Lymphogranuloma Venereum, Nongonococcal Urethritis, Ocular Rosacea, Ornithosis, Pelvic Inflammatory Disease, Pemphigoid, Pemphigus, Pneumonia, Psittacosis, Rheumatoid Arthritis, Rickettsial Infection, Syphilis, Early, Syphilis, Latent, Tertiary Syphilis, Upper Respiratory Tract Infection.

Side Effect

Possible side effects of Taracycline include: Increased sensitivity of skin to sunlight (rare with minocycline); implant, powder for suspension; Pigmentation (darker color or discoloration) of skin and mucous membranes; Abdominal pain; increased thirst.

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Precautions

See also Side Effects section.

Before taking Taracycline, tell your doctor or pharmacist if you are allergic to it; or to other Taracyclines (e.g., doxycycline, minocycline), or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, problems swallowing, esophagus problems (e.g., hiatal hernia, reflux disease-GERD).

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Taracycline may cause live bacterial vaccines (such as typhoid vaccine) to not work as well. Do not have any immunizations/vaccinations while using this medication unless your doctor tells you to.

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

Before having surgery, tell your doctor or dentist that you are using Taracycline.

Caution is advised when using this drug in the elderly because they may be more sensitive to its effects.

This medication should not be used in children younger than 8 years of age because it may cause permanent tooth discoloration and other problems. Tooth discoloration has also occurred in older children and young adults. Consult your doctor for more information.

This medication is not recommended for use during pregnancy. It may harm an unborn baby. Consult your doctor for more details.

This medication passes into breast milk. Consult your doctor before breast-feeding.

Warnings

This medication contains Taracycline. Do not take Sumycin, Actisite, or Achromycin V if you are allergic to Taracycline or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Taracyclines

Taracyclines have been used since 1950s for treating a variety of Gram-positive and Gram-negative infections. In addition, Taracyclines are also used to treat infections due to intracellular chlamydiae, mycoplasmas, rickettsiae, and protozoa parasites. Taracycline antibiotics are inexpensive making them attractive for use in developing countries. Taracyclines can also be used prophylactically and also for the treatment of community-acquired infections especially respiratory infections. Ten different Taracycline derivatives have been marketed but doxycycline and minocycline are more commonly prescribed and can be administered orally. Tigecycline was developed later to overcome Taracycline resistance. Tigecycline is administered intravenously.

Taracyclines reversibly inhibit bacterial protein synthesis by binding to the ribosomal complex thus preventing the association of aminoacyl-tRNA with bacterial ribosome. The cause of Taracycline resistance is due to acquisition of Taracycline resistance genes. More than 33 genes have been characterized and 23 of these genes encode efflux pump which are responsible for expelling antibiotics from bacterial cells. Ten other genes code for ribosomal protection proteins with very low affinity to bind with Taracycline drugs. These genes mostly confer resistance to Taracycline, doxycycline, and minocycline .

Tigecycline overcomes the two major resistance mechanisms of Taracycline; drug specific efflux pump acquisition by the bacteria and ribosomal protection. Tigecycline is effective against many Gram-positive and Gram-negative organisms including MRSA, vancomycin intermediate and VRE, and ESBL producing E. coli and K. pneumoniae. It is also active against many anaerobic bacteria as well as atypical pathogens including rapidly growing nontuberculous mycobacteria. Tigecycline is eliminated primarily through biliary excretion. Therefore, impaired renal function has no effect on its clearance. Common side effects are nausea and vomiting .

What should I avoid while taking Taracycline?

For at least 2 hours before or 2 hours after taking Taracycline: avoid taking iron supplements, multivitamins, calcium supplements, antacids, or laxatives.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Avoid exposure to sunlight or tanning beds. Taracycline can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Usual Adult Dose for Epididymitis - Sexually Transmitted

500 mg orally every 6 hours for 10 days

The patient's sexual partner(s) should also be evaluated/treated.

Doxycycline for 10 days, in conjunction with a single dose of a parenteral third-generation cephalosporin like ceftriaxone, has been specifically recommended by the CDC as primary treatment for sexually transmitted epididymitis. Taracycline may be a reasonable substitute for doxycycline in this regimen.

What Are Side Effects Associated with Using Taracycline?

Common side effects of Taracycline include:

  • Discoloration of teeth and enamel hypoplasia (young children)
  • Diarrhea
  • Nausea
  • Photosensitivity
  • Stomach upset
  • Loss of appetite
  • White patches or sores inside your mouth or on your lips
  • Swollen tongue
  • Black hairy tongue
  • Sore throat
  • Trouble swallowing
  • Dizziness
  • Headache
  • Sores or swelling in your rectal or genital area
  • Vaginal itching or discharge

Less common side effects of Taracycline include:

Serious side effects of Taracycline include:

  • Sunburn (sun sensitivity)
  • Musclepain
  • Changes in the amount of urine
  • Brown or gray tooth discoloration
  • Numbness or tingling of the hands or feet
  • Unusual fatigue
  • New signs of infection (e.g., persistent sorethroat, fever, chills)
  • Hearing changes (e.g., ringing in the ears, decreased hearing)
  • Easy bruising or bleeding
  • Severe stomach or abdominal pain
  • Yellowing eyes or skin
  • Dark urine

This is not a complete list of side effects and other serious side effects may occur. Call your doctor for information and medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Q: Does Taracycline cause weight gain or weight loss?

A: The product information for Taracycline does not list weight gain as a side effect, but it does list loss of appetite, which may lead to weight loss. Patients should contact their health care provider for any changes in their medical condition, including unusual changes in appetite or weight. For more specific information, consult your physician or health care provider. You may also find helpful information at: //www.everydayhealth.com/drugs/Taracycline.

Before taking Taracycline,

  • tell your doctor and pharmacist if you are allergic to Taracycline, minocycline, doxycycline, demeclocycline, any other medications, or any of the ingredients in the Taracycline capsule. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven), and penicillin.
  • be aware that antacids containing magnesium, aluminum, calcium, or sodium bicarbonate, calcium supplements, zinc products, iron products, and laxatives containing magnesium interfere with Taracycline, making it less effective. Take Taracycline 2 hours before or 6 hours after antacids, calcium supplements, zinc products, and laxatives containing magnesium. Take Taracycline 2 hours before or 4 hours after iron preparations and vitamin products that contain iron. Take Taracycline 2 hours before or after zinc containing products.
  • tell your doctor if you have or have ever had lupus (condition in which the immune system attacks many tissues and organs including the skin, joints, blood, and kidneys), or kidney disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking Taracycline, call your doctor immediately. Taracycline can harm the fetus.
  • plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Taracycline may make your skin sensitive to sunlight. Tell your doctor right away if you get a sunburn.
  • you should know that when Taracycline is used during pregnancy or in babies or children up to age 8, it can cause the teeth to become permanently stained. Taracycline should not be used in children under age 8 unless your doctor decides it is needed.

How Did This Get Here?

Taracycline teeth stains develop on permanent teeth while they are still forming under the gum line. During development, the drug becomes calcified in the tooth, generating Taracycline tooth stains. Children are susceptible to Taracycline tooth stains from the time they are in utero until the age of 8. Since teeth start to develop before we're even born, pregnant women should not take Taracycline to prevent the possibility of the drug affecting the unborn baby's oral health.

Gray or brown in color, these deep, dark stains either cover the entire tooth or appear as a pattern of horizontal stripes. Because they form during tooth development, Taracycline teeth stains are embedded in the tooth's enamel and inner layers. This classifies them as intrinsic stains -- discoloration that comes from inside the tooth. Although harmless, Taracycline stains are obvious and permanent, often causing embarrassment and low self-esteem in those who suffer from them.

Did You Know?

Most chemical names are made up of two or more Greek and Latin roots strung together. Thus, Taracycline, with its cycl- root from the Greek word for "circle", means "four-ringed"—that is, "consisting of four fused hydrocarbon rings". Antibiotics work against bacteria and other tiny organisms (but not viruses); Taracycline, which comes from a kind of soil bacteria, is one of the most used of the antibiotics. "Broad-spectrum" antibiotics work well on numerous organisms; thus, Taracycline has proved effective against acne, chlamydia, cholera, rickets, and various lung and eye infections, among many other conditions.

What are doxycycline and Taracycline?

Doxycycline is a synthetic (man-made) antibiotic derived from Taracycline. Doxycycline is used for many different types of infections, including respiratory tract infections due to Hemophilus influenzae, Streptococcus pneumoniae, or Mycoplasma pneumoniae. It also is used for the treatment of non-gonococcal urethritis (due to Ureaplasma), Rocky Mountain spotted fever, typhus, chancroid, cholera, brucellosis, anthrax, syphilis, acne, and periodontal disease.

Taracycline is a broad-spectrum antibiotic, that is, it is active against many different types of bacteria. Taracycline prevents growth of bacteria by preventing the bacteria from manufacturing proteins that they need to survive. It is effective against Hemophilus influenzae, Streptococcus pneumoniae, Mycoplasma pneumoniae, Chlamydia psittaci, Chlamydia trachomatis, Neisseria gonorrhoeae, and many others. Taracycline is used for infections of the respiratory tract, urinary tract, and skin; urethritis, typhus, Rocky Mountain spotted fever, certain sexually transmitted diseases (STDs), acne, anthrax, cholera, and H. pylori.

What other drugs will affect Taracycline?

Tell your doctor about all your current medicines and any you start or stop using, especially:

any other antibiotic;

tretinoin (Renova, Retin-A, Vesanoid);

a blood thinner (warfarin, Coumadin, Jantoven);

an antacid or laxative medicine; or

a vitamin or mineral supplement that contains iron, zinc, calcium, or magnesium.

This list is not complete. Other drugs may interact with Taracycline, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Taracycline and Other Interactions

Consuming dairy products, such as milk, yogurt, cheese, and ice cream, may interfere with the absorption of Taracycline. You should talk to your doctor about this interaction.

This medication may make your skin more sensitive to sunlight. You should avoid unnecessary or prolonged sun exposure while taking Taracycline.

Pre-Clinical Research

Taracyclines have a broad spectrum of activity against many gram-positive and gram-negative bacteria as well as Mycoplasma, Chlamydia, Rickettsiae, Plasmodia, and amoebae. They are usually bacteriostatic. They are also active against Streptococcus pneumoniae. The Taracyclines are active against most gram-positive bacilli, including Actinomyces israelii, Arachnia, Bacillus anthracis, Listeria monocytogenes, and most clostridia and Nocardia. Many gram-negative bacteria are resistant to Taracyclines. Penicillin-sensitive Neisseria gonorrhoeae and meningococci are sensitive to Taracyclines, whereas penicillin-resistant gonococci tend to be resistant to them. Most community acquired E.coli, Xanthomonas maltophilia, and Pseudomonas pseudomallei are sensitive to Taracyclines, as are most vibrios, Campylobacter, Helicobacter, Pasturella multocida, Brucella, and some Haemophilus spp Klein and Cunha (1995) .

Doxycycline

  • It is recommended that doxycycline not be taken at the same time as aluminum, magnesium, or calcium based antacids, such as Mylanta, Maalox, Tums, or Rolaids because, like food, these medications bind doxycycline in the intestine and prevent its absorption. Similarly, doxycycline should not be taken with minerals (such as calcium or iron) or with bismuth subsalicylate (Pepto Bismol).
  • Doxycycline may enhance the activity of warfarin (Jantoven, Coumadin) and cause excessive "thinning" of the blood leading to exaggerated bleeding, necessitating a reduction in the dose of warfarin. Phenytoin (Dilantin), carbamazepine (Tegretol), and barbiturates (such as phenobarbital) may enhance the metabolism (destruction) of doxycycline thus making it less effective.
  • Doxycycline may interfere with the action of penicillins and should not be combined with penicillins. It may also reduce the effect of oral contraceptives. Combining Taracycline and methoxyflurane (Penthrane) may reduce kidney function.

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