Surnox

Surnox

  • Active Ingredient: Ofloxacin
  • 400 mg, 200 mg
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What is Surnox?

The active ingredient of Surnox brand is ofloxacin. Ofloxacin is a fluoroquinolone (flor-o-KWIN-o-lone) antibiotic that fights bacteria in the body. Ofloxacin, USP is an off-white to pale yellow crystalline powder. The molecule exists as a zwitterion at the pH conditions in the small intestine. The relative solubility characteristics of Ofloxacin, USP at room temperature, as defined by USP nomenclature, indicate that Ofloxacin, USP is considered to be soluble in aqueous solutions with pH between 2 and 5. It is sparingly to slightly soluble in aqueous solutions with pH 7 (solubility falls to 4 mg/mL) and freely soluble in aqueous solutions with pH above 9. Ofloxacin, USP has the potential to form stable coordination compounds with many metal ions. This in vitro chelation potential has the following formation order: Fe +3 > Al +3 > Cu +2 > Ni +2 > Pb +2 > Zn +2 > Mg +2 > Ca +2 > Ba +2.

Used for

Surnox is used to treat diseases such as: Anthrax, Anthrax Prophylaxis, Bladder Infection, Bone infection, Bronchitis, Campylobacter Gastroenteritis, Cervicitis, Chancroid, Chlamydia Infection, Epididymitis, Non-Specific, Epididymitis, Sexually Transmitted, Gonococcal Infection, Disseminated, Gonococcal Infection, Uncomplicated, Joint Infection, Kidney Infections, Methicillin-Resistant Staphylococcus Aureus Infection, Mycobacterium avium-intracellulare, Treatment, Nongonococcal Urethritis, Pelvic Inflammatory Disease, Plague, Pneumonia, Prostatitis, Salmonella Enteric Fever, Salmonella Gastroenteritis, Shigellosis, Skin or Soft Tissue Infection, Traveler's Diarrhea, Tuberculosis, Active, Urinary Tract Infection.

Side Effect

Possible side effects of Surnox include: headache; excess air or gas in the stomach or intestines; Abdominal or stomach pain; high fever; increased urination; cold sweats.

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How should this medicine be used?

Ophthalmic Surnox comes as an solution (liquid) to instill in the eye. It is usually instilled in the affected eye(s) four or more times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use Surnox exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

How should I take Surnox?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take Surnox with water, and drink extra fluids to keep your kidneys working properly.

You may take Surnox with or without food, at the same time each day.

Use Surnox for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Surnox will not treat a viral infection such as the flu or a common cold.

Do not share Surnox with another person.

This medicine may affect a drug-screening urine test and you may have false results. Tell the laboratory staff that you use Surnox.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Microbiology

Surnox has in vitro activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Surnox is bactericidal at concentrations equal to or slightly greater than inhibitory concentrations. Surnox is thought to exert a bactericidal effect on susceptible bacterial cells by inhibiting DMA gyrase, an essential bacterial enzyme which is a critical catalyst in the duplication, transcription, and repair of bacterial DMA.

Cross-resistance has been observed between Surnox and other fluoroquinolones. There is generally no cross-resistance between Surnox and other classes of antibacterial agents such as beta-lactams or aminoglycosides. Surnox has been shown to be active against most strains of the following organisms both in vitro and clinically, in conjunctival and/or corneal ulcer infections as described in the INDICATIONS section.

The safety and effectiveness of Surnox ophthalmic solution in treating ophthalmologic infections due to the following organisms have not been established in adequate and well-controlled clinical trials. Surnox ophthalmic solution has been shown to be active in vitro against most strains of these organisms but the clinical significance in ophthalmologic infections is unknown.

Getting the most from your treatment

  • Before you start the treatment, read the manufacturer's printed information leaflet from the pack. The manufacturer's leaflet will give you more information about the drops, and a full list of side-effects which you may experience from using them.
  • If your eyes have an obvious discharge or 'crust', it can help if you bathe them with cool clean water before using Surnox.
  • Use the drops regularly, exactly as your doctor tells you to. If the infection is severe, this is likely to be every 2-4 hours for the first two days. (Just use the drops while you are awake - you do not need to wake yourself up during the night to put them in.) On day three, reduce the frequency down to four times a day.
  • If your symptoms do not improve within a few days, or if they become worse, speak again with your doctor.
  • When you first put the drops into your eye, it may cause blurred vision. This should quickly clear, but make sure you can see clearly again before you drive or use machines or tools.
  • Take care to avoid spreading the infection from one eye to the other, and to other members of your family. Washing your hands regularly (particularly after touching your eyes), and not sharing towels or pillows will help to prevent the infection from spreading.
  • If the tip of the bottle touches your eye(s) when putting the drops in, it is a good idea to squeeze out two or three drops straightaway on to some tissue and rinse the tip with salt water.
  • Eye infections, or using Surnox eye drops, may cause your eyes to become more sensitive to sunlight than usual. Wearing sunglasses may help to protect your eyes.
  • If you are using any other eye drops, leave at least five minutes between applying each preparation. This is to prevent more liquid going into your eye than it can handle. Otherwise the drops will overflow from your eye and not have the intended effect.
  • Even when your eye appears normal again, there may still be some bacteria present. It is important to continue to use the drops for a further 48 hours once your eye appears normal. This will help to make sure that all the bacteria have been killed. It is likely that you may need to use the drops for about a week, but you should not use them for any longer than 10 days.
  • Do not wear contact lenses until your symptoms have completely gone. Wait for 24 hours after the last dose of eye drops before using your lenses again.

How to use Surnox Drops

To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.

Do not wear contact lenses while you are using this medicine. Sterilize contact lenses according to manufacturer's directions and check with your doctor before using them.

Tilt your head back, look upward and pull down the lower eyelid to make a pouch. Hold the dropper directly over the eye and place one drop into the eye. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure. This will prevent the medication from draining out. Try not to blink and do not rub your eye. Repeat these steps for your other eye if so directed, and if your dose is for more than 1 drop.

Do not rinse the dropper. Replace the dropper cap after each use.

If you are using another kind of eye medication (e.g., drops or ointments), wait at least 5 minutes before applying other medications. Use eye drops before eye ointments to allow the eye drops to enter the eye.

Use this medication regularly in order to get the most benefit from it. Continue using it for the full time prescribed even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a relapse of the infection.

Inform your doctor if your condition persists or worsens.

Surnox

Pharmacologic class: Fluoroquinolone

Therapeutic class: Anti-infective

Pregnancy risk category C

PATIENT INFORMATION

Avoid contaminating the applicator tip with material from the eye, fingers or other source.

Systemic quinolones, including Surnox, have been associated with hypersensitivity reactions, even following a single dose. Discontinue use immediately and contact your physician at the first sign of a rash or allergic reaction.


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