H. pylori Eradication To Reduce The Risk Of Duodenal Ulcer Recurrence
Randomized, double-blind clinical studies performed in the United States in patients with H. pylori and duodenal ulcer disease (defined as an active ulcer or history of an ulcer within 1 year) evaluated the efficacy of lansoprazole in combination with Suplentin capsules and clarithromycin tablets as triple 14-day therapy, or in combination with Suplentin capsules as dual 14-day therapy, for the eradication of H. pylori. Based on the results of these studies, the safety and efficacy of 2 different eradication regimens were established: Triple therapy: Suplentin 1 gram twice daily/clarithromycin 500 mg twice daily/lansoprazole 30 mg twice daily (see Table 6). Dual therapy: Suplentin 1 gram three times daily/lansoprazole 30 mg three times daily (see Table 7. All treatments were for 14 days. H. pylori eradication was defined as 2 negative tests (culture and histology) at 4 to 6 weeks following the end of treatment. Triple therapy was shown to be more effective than all possible dual therapy combinations. Dual therapy was shown to be more effective than both monotherapies. Eradication of H. pylori has been shown to reduce the risk of duodenal ulcer recurrence.
Table 6: H. pylori Eradication Rates When Suplentin is Administered as Part of a Triple Therapy Regimen
Table 7: H. pylori Eradication Rates When Suplentin is Administered as Part of a Dual Therapy Regimen
1. Swanson-Biearman B, Dean BS, Lopez G, Krenzelok EP. The effects of penicillin and cephalosporin ingestions in children less than six years of age. Vet Hum Toxicol. 1988; 30: 66-67.
2. Clinical and Laboratory Standards Institute (CLSI). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically; Approved Standard – Tenth Edition. CLSI document M07-A10, Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2015.
3. Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Disk Diffusion Susceptibility Tests; Approved Standard – Twelfth Edition. CLSI document M02-A12, Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2015.
4. Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing; Twenty-fifth Informational Supplement, CLSI document M100-S25. CLSI document M100-S25, Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2015.
Q: Celestamine, Piriton, Amoxil, and Flugone are the drugs that I occasionally take. What are the side effects?
A: Amoxil (Suplentin) is an antibiotic that is used to treat a wide variety of bacterial infections. The most common side effects of Suplentin are diarrhea, nausea, and vomiting. Rarely, severe side effects can occur when taking Suplentin such as severe allergic reactions (rash, hives, itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; confusion; dark urine; fever, chills, or persistent sore throat; red, swollen, blistered, or peeling skin; seizures; severe diarrhea; stomach pain or cramps; and unusual bruising or bleeding. Stop taking Suplentin immediately, and consult your physician immediately if any of these severe effects occur. Celestamine, Piriton, and Flugone are not approved for use in the United States; therefore, I cannot provide any information about these medications. Burton Dunaway, PharmD
Why is this medication prescribed?
Suplentin is used to treat certain infections caused by bacteria, such as pneumonia; bronchitis (infection of the airway tubes leading to the lungs); and infections of the ears, nose, throat, urinary tract, and skin. It is also used in combination with other medications to eliminate H. pylori, a bacteria that causes ulcers. Suplentin is in a class of medications called penicillin-like antibiotics. It works by stopping the growth of bacteria.
Antibiotics such as Suplentin will not work for colds, flu, and other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.
Dosing In Renal Impairment
Suplentin is primarily eliminated by the kidney and dosage adjustment is usually required in patients with severe renal impairment (GFR
- Suplentin is a broad-spectrum penicillin antibiotic available by prescription used to treat various infections caused by susceptible strains of bacteria.
- Suplentin can be used to treat infections such as ear infections, urinary tract infections, and skin infections. Suplentin may also be used for purposes other than those listed.
- Suplentin is available in tablet form in 100 mg and 400 mg strengths, and in capsule form in 250 mg and 500 mg strengths.
Contact your veterinarian immediately if your pet develops severe or bloody diarrhea. Give all of the Suplentin that is prescribed for your pet. Symptoms may begin to improve before the infection is completely treated.
Suplentin in vitro susceptibility testing methods for determining minimum inhibitory concentrations (MICs) and zone sizes have not been standardized, validated, or approved for testing H. pylori. Specimens for H. pylori and clarithromycin susceptibility test results should be obtained on isolates from patients who fail triple therapy. If clarithromycin resistance is found, a non-clarithromycin-containing regimen should be used.
Nausea, vomiting, or diarrhea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection (oral or vaginal fungal infection). Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge or other new symptoms.
Tell your doctor right away if any of these rare but serious side effects occur: dark urine, persistent nausea or vomiting, stomach/abdominal pain, yellowing eyes or skin, easy bruising or bleeding, persistent sore throat or fever.
This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea or opioid medications if you have the following symptoms because these products may make them worse. Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
Suplentin can commonly cause a mild rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe allergic reaction. Therefore, get medical help right away if you develop any rash.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Q: My allergist has me on a 30 day regimen of 4 prednisone daily for 1 week, 3 the next week, 2 the next and 1 the 4th week. At the same time, I'm to take 1 Suplentin twice daily. Now, in the 3rd week, I'm feeling a lot of stomach pain and wonder if this is related?
A: Stomach pain and/or cramping is a common side effect of Suplentin. Other common side effects include nausea, vomiting, and diarrhea. Contact your healthcare provider right away if the stomach pain is severe or accompanied by diarrhea, blood in your stool, fever, yellowing of the skin, loss of appetite, dark urine, or clay-colored stools. You may also find helpful information at //www.everydayhealth.com/drugs/Suplentin Sarah McKenney Lewis, PharmD
home drugs a-z list Amoxil(Suplentin) side effects drug center
Find Lowest Prices on
Amoxil (Suplentin) is a penicillin-type antibiotic used to treat infections caused by bacteria that are B-lactamase negative (B-lactamase positive bacteria are usually resistant to Amoxil); these infections usually occur in the skin, lungs, urinary tract and eye, ears, nose, and throat. Amoxil is available as a generic drug termed Suplentin. Amoxil may be combined with other drugs (for example, clavulanic acid ), to make the antibiotic more effective. Common side effects of Amoxil include:
- stomach pain
- vaginal itching or discharge
- rash, and
- swollen, black, or "hairy" tongue.
Other serious side effects of Amoxil include:
- colitis caused by overgrowth of Clostridium spp in the intestines
- jaundice, and
Amoxil is available in many preparations (capsules, tablets, chewable tablets, powder for oral suspension and pediatric oral suspension). Serious reactions of Amoxil include anaphylactic reactions that can be life-threatening; patients allergic to penicillins should not be given Amoxil. Amoxil may interact with probenecid, blood thinners, other antibiotics, or sulfa drugs. Tell your doctor all medications and supplements you use. Treatment in pregnant women and women who are breastfeeding should be done with caution.
Our Amoxil Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.