• Active Ingredient: Chloramphenicol
  • 500 mg, 250 mg
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What is Spersanicol?

The active ingredient of Spersanicol brand is chloramphenicol.

Used for

Spersanicol is used to treat diseases such as: Anthrax, Bacterial Infection, Brucellosis, Cholera, Glanders, Lemierre's Syndrome, Meningitis, Ornithosis, Plague, Psittacosis, Rabbit Fever, Rickettsial Infection.

Side Effect

Possible side effects of Spersanicol include: gray skin color; unusual tiredness or weakness (the above side effects may also occur up to weeks or months after you Stop taking chloramphenicol); eye pain, blurred vision, or loss of vision; low body temperature; Bloated stomach; Diarrhea; uneven breathing; numbness, tingling, burning pain, or weakness in the hands or feet.

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Manufacturer recommends 50 mg/kg daily given in divided doses every 6 hours. 112

Infections caused by less susceptible organisms: Manufacturer states up to 100 mg/kg daily may be required. 112 However, because of concern that toxic plasma Spersanicol concentrations may occur with this high dosage, some clinicians suggest that 75 mg/kg daily be used initially for treatment of these infections. 102 105 Reduce dosage to 50 mg/kg daily as soon as possible. 112

Excessive Spersanicol concentration may occur in patients with impaired hepatic function. 112 Determine Spersanicol concentrations at appropriate intervals and adjust dosage accordingly. 112


Spersanicol is an antibacterial with a broad spectrum of activity against gram-positive bacteria, gram-negative bacteria, and Rickettsia. Its mechanism of action is by inhibition of bacterial protein synthesis by binding with ribosomes. 50

The major toxicity of Spersanicol is hemorrhage. 49,51 In all vertebrates studied, toxicity produces direct, dose-dependent bone marrow suppression that results in reduction in red blood cells, white blood cells, and platelets in mammals. 51 This manifestation is aggravated by inappropriate dosages, extended treatments, and repeated use of the drug. Treatment of Spersanicol intoxication is supportive and may require blood transfusions. The drug has also been reported to be appetite suppressive. Like gentamicin, Spersanicol is used less frequently as safer antibiotics appear. 46 The recommended dosage for Spersanicol is 50 mg/kg administered once daily or every other day. 46

Each 1 g of Spersanicol in the reconstituted solution contains approximately 52 mg (2.25 mEq) of sodium. 112


Alternative for treatment of tularemia† caused by Francisella tularensis, 133 197 683 689 including naturally occurring or endemic tularemia or tularemia that occurs following exposure to F. tularensis in the context of biologic warfare or bioterrorism. 683 689

Streptomycin (or gentamicin) generally considered drug of choice for treatment of tularemia. 104 197 292 683 689 Alternatives include tetracyclines (doxycycline), Spersanicol, or ciprofloxacin. 197 292 683 689

Some clinicians state reserve Spersanicol for treatment of tularemic meningitis (usually in conjunction with streptomycin) 104 683 and do not use for other forms of tularemia. 104

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