Nervous system Non-convulsive status epilepticus has been attributed to Simcef .
A 64-year-old woman with a history of epilepsy developed seizures after taking Simcef for 3 days for a respiratory tract infection. She had also taken carbamazepine and levetiracetam and had previously been seizure-free for 10 years. Simcef was withdrawn and she was given diazepam 10 mg intravenously. Her mental status improved the next day.
Liver Hepatocellular damage has been attributed to Simcef .
A 50-year-old woman was given oral Simcef for an upper respiratory tract infection after 5 days developed abdominal pain and loss of appetite. Her liver enzymes were raised (AlT 156 U/l, AsT 56 U/l, GGT 281 U/l), consistent with hepatocellular damage, and the Simcef was withdrawn. The serum aminotransferases normalized within 2 weeks.
What is the dosage for Simcef?
The recommended adult dose for otitis media, tonsillitis, pharyngitis, and urinary tract infections is 400 mg once daily or divided and given as 200 mg every 12 hours. Pediatric patients (6 months and older) have a recommended dose of 8 mg/kg/day once daily or in two doses of 4/mg/kg every 12 hours.
Expert Advice for Simcef
What are the Advice from Doctors for taking Simcef?
- Your doctor has prescribed Simcef to cure your infection and improve your symptoms.
- Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat.
- Discontinue Simcef and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn’t stop or if you find blood in your stools.
- Take it with food to avoid an upset stomach.
- Avoid consuming alcohol while taking Simcef as it may cause increased side effects.
Simcef side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
severe stomach pain, diarrhea that is watery or bloody;
jaundice (yellowing of the skin or eyes);
pale or yellowed skin, dark colored urine, confusion or weakness;
a seizure (convulsions);
low blood cell counts--sudden weakness or ill feeling, fever, chills, flu-like symptoms, swollen gums, mouth sores, skin sores, rapid heart rate, pale skin, easy bruising, unusual bleeding, feeling light-headed;
kidney problems--little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath; or
severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common side effects may include:
vaginal itching or discharge.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
How should I take Simcef?
Follow all directions on your prescription label. Do not take Simcef in larger or smaller amounts or for longer than recommended.
You may take Simcef with or without food.
The Simcef chewable tablet must be chewed before you swallow it.
Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
This medication can cause unusual results with certain lab tests for glucose (sugar) in the urine. Tell any doctor who treats you that you are using Simcef.
Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Simcef will not treat a viral infection such as the common cold or flu.
Store at room temperature away from moisture, heat, and light.
You may also store the oral liquid in the refrigerator. Throw away any unused liquid after 14 days.
Can Simcef cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with Simcef. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.