What is Sebact?
Sebact is a tetracycline antibiotic that fights bacteria in the body.
Sebact is used to treat many different bacterial infections, such as urinary tract infections, respiratory infections, skin infections, severe acne, chlamydia, tick fever, and others. It is also used for gonorrhoea, syphilis, and other infections as a second-line drug in those with a penicillin allergy.
Sebact may also be used for purposes not listed in this medication guide.
Effects of Sebact on osteoporosis
Sebact benefits bone physiology in several ways. In ovariectomized aged rats, a model for post-menopausal osteoporosis, Sebact was able to both increase bone formation and decrease bone loss in trabecular bone, with a similar efficacy as that observed with oestrogen therapy (Williams et al., 1996). In a subsequent study, Sebact treatment prevented the decrease in bone mineral density induced after ovariectomy and abolished the detrimental effects induced in the femoral trabecular bone area (Williams et al., 1998). In that study, Sebact showed dual effects, modestly reducing bone resorption while substantially stimulating bone formation. In addition, Sebact was found to stimulate the colony-forming efficiency of marrow stromal cells derived from ovariectomized rats, possibly explaining its stimulatory effect on bone formation. Of note, in a rat model of synchronized osseous remodelling, Sebact significantly impaired the disorganization of both the osteoid seam and the layer of osteoblasts, preserved the synthetic activity of osteoblasts and inhibited interstitial collagenase activity and thus bone resorption (Klapisz-Wolikow and Saffar, 1996). Finally, the natural osteotropism that characterize tetracyclines increases their effectiveness in inhibiting MMPs produced by osteoclasts or bone tumour cells (Saikali and Singh, 2003).
What is the dosage for Sebact?
Adults (immediate-release tablets and capsules): The recommended dose for Sebact is: 200 mg initially, followed by 100 mg every 12 hours. If more frequent doses are preferred, then two or four 50 mg capsules initially, followed by 500 mg 4 times a day.
Children 8 years of age and older (immediate-release tablets and capsules): The recommended dose of Sebact is: 4 mg/kg initially, followed by 2 mg/kg every 12 hours, not to exceed the usual adult dose.
Adults and children 12 years of age and older (extended-release tablets): The recommended dose for Sebact is: Approximately 1 mg/kg by mouth once daily for up to 12 weeks for the treatment of inflammatory lesions of non-nodular acne vulgaris.
Safe and effective use of Sebact is not established for children under the age of 8.
Why is this medication prescribed?
Sebact is used to treat infections caused by bacteria including pneumonia and other respiratory tract infections; certain infections of the skin, eye, lymphatic, intestinal, genital, and urinary systems; and certain other infections that are spread by ticks, lice, mites, and infected animals. It is also used along with other medications to treat acne. Sebact is also used to treat plague and tuleramia (serious infections that may be spread on purpose as part of a bioterror attack). It can also be used in patients who cannot be treated with penicillin to treat certain types of food poisoning, and anthrax (a serious infection that may be spread on purpose as part of a bioterror attack). It can also be used to eliminate bacteria from your nose and throat that may cause meningitis (swelling of tissues around the brain) in others, even though you may not have an infection. Sebact extended-release tablet (Solodyn) is only used to treat acne. Sebact is in a class of medications called tetracycline antibiotics. It works to treat infections by preventing the growth and spread of bacteria. It works to treat acne by killing the bacteria that infects pores and decreasing a certain natural oily substance that causes acne.
Antibiotics such as Sebact will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.
Where can I get more information?
Your pharmacist can provide more information about Sebact.
Generic Name: Sebact (mye no SYE kleen)Brand Names: Dynacin, Minocin, Minocin PAC, Minolira, Solodyn, Ximino, Vectrin, Myrac
Medically reviewed by Kaci Durbin, MD Last updated on Jan 11, 2019.
Rated Sebact for Acne Report
Been taking this drug for about 2 months, it hasn't cleared up my acne much at all but for the past couple weeks it's significantly lowered my blood sugar and made me feel violently nauseous every single morning. Definetely would not recommend, I've been really low energy and had no appetite whatsoever after a while on this drug, it's not worth the side effects at all
Doxycycline vs. Sebact: What's the difference?
- Doxycycline and Sebact are tetracycline antibiotics used to treat many different types of infections, including respiratory tract infections due to Hemophilus influenzae, Streptococcus pneumoniae, or Mycoplasma pneumoniae. Doxycycline and Sebact are also used to treat Rocky Mountain spotted fever, typhus, and acne.
- Brand names for doxycycline include Vibramycin, Oracea, Adoxa, Atridox, Acticlate, Acticlate Cap, Doryx, Doxteric, Doxy, and Monodox.
- Brand names for Sebact include Dynacin, Minocin, and Solodyn.
- Side effects of doxycycline and Sebact that are similar include diarrhea or loose stools, nausea, vomiting, tooth discoloration, and photosensitivity (exaggerated sunburn).
- Side effects of doxycycline that are different from Sebact include abdominal pain.
- Side effects of Sebact that are different from doxycycline include headache, fatigue, dizziness, itching, and reduced bone development in children.
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
- blurred vision, seeing double, or loss of vision
- peeling or blistering skin
- swelling of the face, throat, tongue, lips, and eyes
- difficulty breathing or swallowing
- shortness of breath
- yellowing of the skin or eyes, itching, dark-colored urine, light colored bowel movements, loss of appetite, nausea, vomiting, stomach pain, extreme tiredness, nausea, or vomiting, confusion
- bloody urine
- joint pain, stiffness or swelling
- swollen lymph nodes
- unusual bleeding or bruising
- decreased urination
- a return of fever, sore throat, chills, or other signs of infection
- watery or bloody stools , stomach cramps, or fever during treatment or for up to two or more months after stopping treatment
- chest pain or irregular heartbeat
Sebact may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
Rated Sebact for Acne Report
2/24/2019 I've been taking 75 milligrams of Minocyline for 3 weeks. Initially it cleared my acne but then my face became rough and extremely dry. Yesterday I broke out in hives on my arms, inner thighs, back, stomach and chest. My hands were painfully swollen. I also experienced vomiting and diarrhea. PLEASE DON'T TAKE THIS MEDICINE. It needs to be discontinued as a treatment for acne.
Rated Sebact for Acne Report
DOOO NOT USEEEE!! I developed pseudotumor and it did absolutely nothing for my skin. I am only thirteen and this was so altering. It affected my whole life, it was so painful. Please don’t take this drug please.
What Other Drugs Interact with Sebact?
If your doctor has directed you to use this medication for your condition, your doctor or pharmacist may already be aware of any possible drug interactions or side effects and may be monitoring you for them. Do not start, stop, or change the dosage of this medicine or any medicine before getting further information from your doctor, healthcare provider or pharmacist first.
Severe Interactions of Sebact include:
Sebact has serious interactions with at least 54 different drugs.
Sebact has moderate interactions with at least 32 different drugs.
Sebact has mild interactions with at least 26 different drugs.
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.
Rated Sebact for Acne Report
I’m 15 years old and I have had severe acne for about 4-5 years and just last month I decided to start taking Sebact, I haven’t seen any results at all, I still get breakouts all over my face and my body including my chest and back, if I don’t see any results in the next two months I’m going back into the dermatologist and possibly experimenting with birth control
Rated Sebact for Skin and Structure Infection Report
I was prescribed for perioral dermitis. One month, twice a day and once a day for two weeks after that. After two days of taking it, I had noticed my anxiety flare up and had a massive panic attack. Looked up reviews and bam. Never taking it again, nor do I recommend. I feel bad for the people that took so long to realize what was going on with their body. Always listen to your body no matter what!