Santibi tablets

Santibi

  • Active Ingredient: Ethambutol
  • 800 mg, 600 mg, 400 mg
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What is Santibi?

The active ingredient of Santibi brand is ethambutol. Ethambutol is an antibiotic that prevents growth of the tuberculous bacteria in the body. Ethambutol HYDROCHLORIDE (HCL) 100 and 400 mg tablets contain the following inactive ingredients: Gelatin, Hydroxypropyl Methylcellulose, Magnesium Stearate, Sodium Lauryl Sulfate, Sorbitol, Stearic Acid, Sucrose, Titanium Dioxide and other ingredients.

Used for

Santibi is used to treat diseases such as: Mycobacterium avium-intracellulare, Prophylaxis, Mycobacterium avium-intracellulare, Treatment, Tuberculosis, Active.

Side Effect

Possible side effects of Santibi include: fever; skin rash; confusion; Chills; Blurred vision, eye pain, red-green color blindness, or any loss of vision (more common with high doses); headache; Abdominal pain.

How to Buy Santibi tablets online?

To buy Santibi online - simply click on the "Buy Now" button in the top and follow along with our shop. Order and payment takes a few minutes, and all steps are evident. We do not require a medical prescription plus also we have many procedures of payment. Considering each detail of rapid shipping and confidentiality, you may read on the applicable pages on the hyperlinks from the top menu.

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What did we learn from this study?

  • Ocular toxicity can occur among patients receiving Santibi at doses exceeding 20 mg/kg.
  • Ocular toxicity can occur among patients receiving intermittent Santibi (thrice weekly) in the management of tuberculosis.
  • Ocular toxicity reverses and visual functions are usually recovered if Santibi is stopped as soon as visual impairments are detected.
  • It’s critical that patients receive thorough ophthalmic examinations once per month while on the medication.

How to minimize risk of eye damage from Santibi

Before starting Santibi, there are several things that everyone should be encouraged to do. I’m mostly writing this article for myself – but am hoping that other people benefit from these recommendations.

  1. Baseline vision examination: Every Santibi user should receive a thorough vision examination from an ophthalmologist (not an optometrist).

CONTRAINDICATIONS

Santibi HCl is contraindicated in patients who are known to be hypersensitive to this drug. It is also contraindicated in patients with known optic neuritis unless clinical judgment determines that it may be used. Santibi HCl is contraindicated in patients who are unable to appreciate and report visual side effects or changes in vision (e.g., young children, unconscious patients).

  • Sibling Santibi Optic Chiasmopathy.
  • Acute Optic Neuropathy & Residual Chiasmopathy due to Santibi therapy for Pulmonary Mycobacterium Avium Complex Infection.
  • Santibi-Associated Optic Neuropathy.
  • On 2 Rare Cases of Santibi-Associated Optic Chiasmopathy.
  • Santibi optic neuropathy associated with enhancement at the optic chiasm.
  • Optic chiasm involvement on MRI with Santibi-induced bitemporal hemianopia.

Note : If you know of additional cases of Santibi ocular damage that were not mentioned, let me know. (I’ll add links to them here).

What is the most important information I should know about Santibi?

Santibi can cause serious vision problems or irreversible vision loss. You may not be able to take this medicine if you have an eye problem or vision disorder.

Mode of action

Santibi inhibits formation of the mycobacterial cell wall by affecting the synthesis of arabinogalactan. Its MIC is 0.5–2.0 μg/mL in the Bactec 460-TB automated system. 52 Genetic and biochemical evidence suggests that the primary Santibi target is arabinosyl transferase, encoded by the embA and embB genes. 53

Atypical Mycobacterial Infection - I am taking rifampin, Santibi and azithromycin 3 days per week

Updated 19 Oct 2011 • 1 answer

  1. Test k >Ophthalmologist examination : Once per month (minimum).
  2. At-home examination : Daily or weekly. Can use Amsler gr >Potentially-useful supplements for Santibi optic neuropathy

    I’ve compiled a list of supplements that I think might be helpful for the prophylaxis and/or treatment of Santibi optic neuropathy. Understand that the efficacies of these supplements in prophylaxis and treatment of Santibi optic neuropathy remains unknown.

    Do NOT assume that these supplements will help prevent or reverse Santibi optic neuropathy. These are merely supplements that I believe: (1) have mechanisms that could be of potential use in preventing and/or reversing Santibi optic neuropathy; (2) are relatively low-risk (in side effects); (3) are unlikely to interfere with treatment.

    I’ve emailed several Santibi researchers and am awaiting responses for supplement recommendations. If you have any rational recommendations for low-risk, potentially-beneficial supplements for prevention or treatment of Santibi optic neuropathy – let me know.

    • Zinc: Santibi is believed to strip zinc from optic tissues as the primary mechanism by which it inflicts ocular damage. Supplementing with zinc to keep levels as high as possible within the normal range may be protective against ocular toxicity.
    • Copper: Santibi appears to strip copper from tissues within the optic nerve. Supplementing with copper to keep levels as high as possible within the normal range may prov >Other potentially-useful agents

    Principal Display Panel - Santibi 400mg

    NDC 54879- 002 -01 (100ct Bottle)

    Santibi Hydrochloride Tablets, USP 400mg (Film Coated)

    AVERAGE ADULT DAILY DOSAGE:

    15 mg/kg, or 25 mg/kg once every 24 hours.

    See enclosed circular.

    100 Tablets Rx only

    What Is Santibi?

    Santibi is an antibiotic that prevents growth of the tuberculous bacteria in the body.

    Santibi is used to treat tuberculosis (TB), and is usually given together with at least one other tuberculosis medicine.

    Santibi may also be used for purposes not listed in this medication guide.

    Santibi can cause serious vision problems or irreversible vision loss. You may not be able to take this medicine if you have an eye problem or vision disorder.

    You should not use Santibi if you are allergic to it. You may not be able to take Santibi if you have an eye condition called optic neuritis (inflammation of nerve fibers behind your eyes). Your doctor will decide if this treatment is right for if you have an eye disorder.

    Santibi can cause vision problems that may be a sign that you should stop taking the medicine. You may not be able to take Santibi if you cannot recognize or report any changes in your vision. Young children or debilitated patients may not be able to tell someone about vision problems.

    To make sure Santibi is safe for you, tell your doctor if you have:

    • inflammatory eye disorders such as uveitis or iritis;
    • eye problems caused by diabetes;
    • cataracts;
    • liver disease;
    • kidney disease; or
    • gout.

    FDA pregnancy category C. It is not known whether Santibi will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

    Santibi can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

    Santibi should not be given to a child younger than 13 years old.

    Santibi

    Santibi is a synthetic agent that inhibits arabinosyl transferases, which are important in cell wall synthesis of sensitive mycobacteria. It is active against M. tuberculosis and some other mycobacteria such as M. kansasii. Other bacteria are not affected by the drug. Santibi is tuberculostatic, and resistance develops, although slowly, if it is used alone.

    Santibi is given orally because of good absorption from the gastrointestinal tract. Distribution into various body compartments is adequate. The major route of excretion of Santibi is by renal tubular secretion and glomerular filtration, with the drug appearing in the urine mostly as unchanged drug and as two metabolites. Dosage adjustment is required in the presence of renal impairment.

    Adverse reactions to Santibi are infrequent, the most notable being optic neuritis, with symptoms of decreased visual acuity and loss of the ability to perceive the color green. Other adverse effects include gastrointestinal upset; peripheral neuritis; allergic reactions, usually appearing as skin rashes or drug fever; and increased retention of uric acid.

    Treatment of Santibi optic neuropathy

    There is no effective treatment for Santibi optic neuropathy.

    1. Immediate discontinuation of Santibi. If optic neuropathy occurs, it is recommended that the patient immediately discontinue Santibi treatment. This will increase likelihood of recovering visual function.
    2. Nutritious diet and supplementation (?). A nutrient-rich diet in conjunction with the administration of dietary supplements and/or neurotrophic agents may prove useful in reversing ocular damage induced by Santibi.

    DESCRIPTION

    MYAMBUTOL (Santibi hydrochloride) is an oral chemotherapeutic agent which is specifically effective against actively growing microorganisms of the genus Mycobacterium, including M. tuberculosis. The structural formula is:

    MYAMBUTOL (Santibi hydrochloride) 100 and 400 mg tablets contain the following inactive ingredients: Gelatin, Hydroxypropyl Methylcellulose, Magnesium Stearate, Sodium Lauryl Sulfate, Sorbitol, Stearic Acid, Sucrose, Titanium Dioxide and other ingredients.

    Background

    Santibi (eth am' bue tol) is a semisynthetic antibiotic which is bacteriostatic against Mycobacterium tuberculosis. Santibi interferes with the incorporation of mycolic acid into the mycobacterial cell wall, thus inhibiting its cell wall synthesis. Santibi has a broader spectrum of activity against mycobacterial species than isoniazid or rifampin and is therefore used largely in patients with suspected resistance or in atypical mycobacterial infections. Santibi is available in generic forms in tablets of 100 and 400 mg. The recommended dose is 15 mg/kg once daily in combination with other antituberculosis medications such as isoniazid, rifampin, pyrazinamide, and streptomycin. Higher doses are recommended for patients being retreated after a relapse. Common side effects include gastrointestinal upset, nausea, dizziness, fever, and rash. Regularly updated information on guidelines for therapy of tuberculosis is available at the Centers for Disease Control and Prevention website: http://www.cdc.gov/tb/publications/guidelines/Treatment.htm.

    What should I avoid while taking Santibi?

    Avoid taking an antacid containing aluminum hydroxide (Alternagel, Maalox, Mi-Acid, Mylanta, Rulox) within 4 hours after you take Santibi. Some antacids can make it harder for your body to absorb Santibi.

    Santibi side effects

    Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

    Santibi can cause serious vision problems, including vision loss that may be permanent. Stop using Santibi and call your doctor at once if you have any problems with one or both of your eyes, such as:

    blurred vision or trouble focusing;

    loss of vision in one eye that lasts an hour or longer;

    increased sensitivity of your eyes to light;

    loss of color vision; or

    pain with eye movement, pain behind your eyes.

    Call your doctor at once if you have:

    new or worsening cough with fever, trouble breathing;

    numbness of tingling in your hands or feet;

    fever, swollen glands, painful mouth sores, skin sores, cold or flu symptoms, general ill feeling;

    easy bruising or bleeding (nosebleeds, bleeding gums);

    chest pain or shortness of breath with mild exertion;

    little or no urinating;

    liver problems--upper stomach pain, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

    severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

    Common side effects may include:

    itching or rash;

    This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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