Q: Can Saifoxyl cause hair loss?
A: Saifoxyl (Amoxil) is in a drug class called penicillin-type antibiotics. Saifoxyl works by stopping bacterial growth. According to the prescribing information, hair loss is not listed as a side effect associated with treatment with Saifoxyl. There can be many underlying factors that may lead to hair loss. Consult with your health care provider in regards to your symptoms for proper evaluation, diagnosis of the underlying cause and treatment options, if necessary. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Kristen Dore, PharmD
By Chris Iliades, MD | Medically Reviewed by Farrokh Sohrabi, MD
Latest Update: 2014-04-28 Copyright © 2014 Everyday Health Media, LLC
Probenecid decreases the renal tubular secretion of Saifoxyl. Concurrent use of Saifoxyl and probenecid may result in increased and prolonged blood levels of Saifoxyl.
Resistance to Saifoxyl is mediated primarily through enzymes called beta-lactamases that cleave the beta-lactam ring of Saifoxyl, rendering it inactive.
Saifoxyl has been shown to be active against most isolates of the bacteria listed below, both in vitro and in clinical infections as described in the INDICATIONS AND USAGE section.
Missed Dose of Saifoxyl
Take Saifoxyl exactly as directed by your doctor.
Do not stop taking Saifoxyl on your own. Skipping doses or stopping too soon can make your infection harder to treat.
If you miss a dose of Saifoxyl, take the missed dose as soon as you remember.
If it's almost time for your next dose, skip the missed dose.
Do not double your dose to make up for the missed dose.
Serious allergic reaction
Around 1 in 15 people have an allergic reaction to Saifoxyl.
In most cases, the allergic reaction is mild and can take the form of:
- a raised, itchy skin rash
Mild allergic reactions can usually be successfully treated by taking antihistamines.
In rare cases, Saifoxyl can cause a serious allergic reaction (anaphylaxis).
Abnormal prolongation of prothrombin time (increased international normalized ratio ) has been reported in patients receiving Saifoxyl and oral anticoagulants. Appropriate monitoring should be undertaken when anticoagulants are prescribed concurrently. Adjustments in the dose of oral anticoagulants may be necessary to maintain the desired level of anticoagulation.
What is Saifoxyl?
Saifoxyl is a penicillin antibiotic that fights bacteria.
Saifoxyl is used to treat many different types of infection caused by bacteria, such as tonsillitis, bronchitis, pneumonia, gonorrhea, and infections of the ear, nose, throat, skin, or urinary tract.
Saifoxyl is also sometimes used together with another antibiotic called clarithromycin (Biaxin) to treat stomach ulcers caused by Helicobacter pylori infection. This combination is sometimes used with a stomach acid reducer called lansoprazole (Prevacid).
There are many brands and forms of Saifoxyl available and not all brands are listed on this leaflet.
What is the most important thing I should know about Saifoxyl?
Saifoxyl is a prescription medication available as 100 mg and 400 mg tablets, 250 mg and 500 mg capsules. Saifoxyl Drops suspension is also available in a 15 ml bottle. The usual dose of Saifoxyl in dogs and cats is 5-10 mg/lb every 12-24 hours. Contact your veterinarian immediately if your pet develops severe or bloody diarrhea. Give all of the Saifoxyl that is prescribed for your pet, since symptoms may begin to improve before the infection is completely treated.
On this page
- About Saifoxyl
- Key facts
- Who can and can't take Saifoxyl
- How and when to take it
- Side effects
- How to cope with side effects
- Pregnancy and breastfeeding
- Cautions with other medicines
- Common questions
What other drugs will affect Saifoxyl?
Before giving Saifoxyl, tell your veterinarian if your pet is being given another antibiotic (for the same or a different infection), allopurinol, or probenecid. You may not be able to give Saifoxyl or you may need to have the dosage adjusted. Drugs other than those listed here may also interact with Saifoxyl. Talk to your veterinarian or pharmacist before giving any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.
Q: Is antibiotic Saifoxyl compatible with the drug acylovir?
A: There is no known interaction or incompatibility between Saifoxyl/clavulanate potassium and acyclovir. Gregory Latham, RPh
2. BEFORE YOU TAKE YOUR MEDICINE
Do not take this medicine and consult your doctor if the answer to any of the following is yes:
- You have ever had a bad reaction or allergy to any penicillin-type antibiotic You have ever had a skin rash or swelling of the face or neck or shortness of breath when taking any antibiotic You are allergic to any of the ingredients contained in this medicine
Check with your doctor or pharmacist before taking this medicine if:
- You suffer from kidney disease or kidney problems, as you may require a lower dose than normal
- You have glandular fever
Taking other medicines
Check with your doctor or pharmacist if you are taking, or have recently taken any other medicines even those not prescribed by a doctor.
In particular tell your doctor if you are taking any of the following:
- The contraceptive pill (in which case you will have to take extra contraceptive measures such as using a condom)
- Anticoagulants e.g. Warfarin, Phenindione
- Chemotherapy drugs e.g. Methotrexate
- Drugs used to treat gout (which can be caused by the build up of uric acid) e.g. Probenecid, Allopurinol, Sulfinpyrazone
- Some other antibiotics (e.g. Neomycin and tetracyclines can reduce the effect of Saifoxyl)
- Oral typhoid vaccine (may not work if taken with Saifoxyl)
- Some penicillins may increase the effects of muscle relaxing drugs given as part of an anaesthetic for surgery. Tell the doctor you are taking Saifoxyl if you need to have an anaesthetic.
Having urine or blood tests
If you are having urine tests for diabetes (sugar in the urine) or blood tests for liver function let the doctor know. Saifoxyl can affect the results of these tests.
Pregnancy and breast-feeding
Check with your doctor before you take this medicine if you are pregnant or breast-feeding.
What happens if I overdose my pet on Saifoxyl?
Seek emergency veterinary medical treatment if an overdose is suspected. Symptoms of overdose may include muscle spasms or weakness, pain or twitching, seizures, confusion, coma, or agitation.
Getting the most from your treatment
- If you (or your child) have been prescribed the oral liquid medicine, you may find that it causes some staining of the teeth. Brushing the teeth regularly helps to prevent this. Any staining usually disappears soon after the course of antibiotics is finished.
- Even if you feel your infection has cleared up, keep taking the antibiotic until the course is finished (unless a doctor tells you to stop). This is to prevent the infection from coming back.
- Antibiotics are prescribed in short courses of treatment. Your doctor will tell you how long your course of treatment will last - this is not usually for longer than 14 days. If you still feel unwell after finishing the course, go back to see your doctor.
- Some people develop redness and itching in the mouth or vagina (thrush) after taking a course of antibiotics. If this happens to you, speak with your doctor or pharmacist for advice.
- If you are taking the contraceptive 'pill' at the same time as this antibiotic, the effectiveness of the 'pill' can be reduced if you have a bout of being sick (vomiting) or diarrhoea which lasts for more than 24 hours. If this should happen, ask your doctor or pharmacist for advice about what additional contraceptive precautions to use over the following few days. There is no need to use additional precautions for any bouts of sickness or diarrhoea which last for less than 24 hours.
- Saifoxyl can stop the oral typhoid vaccine from working. If you are due to have any vaccinations, make sure the person treating you knows that you are taking this antibiotic.
Abdominal pain is pain that you feel anywhere between your chest and groin. This is often referred to as the stomach region or belly.
Almost everyone experiences pain in the abdomen at one time or another. Most of the time, it is not caused by a serious medical problem. Stomach discomfort or nausea is a common side effect of Saifoxyl. Less common symptoms include abdominal pain and vomiting.
Taking your dose of Saifoxyl with a meal may help prevent this side effect.
To cope with an upset stomach, eat bland, easy to digest foods like soups, crackers, and toast. Peppermint is thought to help upset stomach symptoms. You can take anti-nausea medication if necessary.
If you experience severe, prolonged abdominal pain or see blood in your vomit or stool, seek medication attention immediately.
Q: I was prescribed Saifoxyl 500 mg every eight hours. How much passes to my breast milk, and how much will this affect my baby?
A: Saifoxyl is an antibiotic in the penicillin group of drugs. It fights bacteria in your body. Saifoxyl is used to treat many types of infections caused by bacteria, such as ear infections, bladder infections, pneumonia, gonorrhea, and E. coli or salmonella infection. Penicillins have been shown to be excreted in human milk. Saifoxyl use by nursing mothers may lead to sensitization of infants. Caution should be exercised when Saifoxyl is administered to a nursing woman. When your doctor prescribes a new medication, be sure to discuss all your prescription and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals, and herbals, as well as the foods you eat. Always keep a current list of the drugs and supplements you take and review it with your health care providers and your pharmacist. If possible, use one pharmacy for all your prescription medications and over-the-counter products. This allows your pharmacist to keep a complete record of all your prescription drugs and to advise you about drug interactions and side effects. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action.