Ribomin capsules

Ribomin

  • Active Ingredient: Clindamycin
  • 300 mg, 150 mg
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What is Ribomin?

The active ingredient of Ribomin brand is clindamycin. The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content. The chemical name for clindamycin hydrochloride is Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-α-D-galacto-octopyranoside monohydrochloride.

Used for

Ribomin is used to treat diseases such as: Aspiration Pneumonia, Babesiosis, Bacteremia, Bacterial Endocarditis Prevention, Bacterial Infection, Bacterial Vaginitis, Bone infection, Deep Neck Infection, Diverticulitis, Intraabdominal Infection, Joint Infection, Lemierre's Syndrome, Malaria, Pelvic Inflammatory Disease, Peritonitis, Pneumocystis Pneumonia, Pneumonia, Prevention of Perinatal Group B Streptococcal Disease, Sinusitis, Skin or Soft Tissue Infection, Surgical Prophylaxis, Toxoplasmosis, Toxoplasmosis, Prophylaxis.

Side Effect

Possible side effects of Ribomin include: fever with or without chills; general feeling of tiredness or weakness; blood in the urine or stools; bloating; joint or muscle pain; cloudy urine.

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INDICATIONS

Ribomin is indicated in the treatment of serious infections caused by susceptible anaerobic bacteria.

Ribomin is also indicated in the treatment of serious infections due to susceptible strains of streptococci, pneumococci, and staphylococci. Its use should be reserved for penicillin-allergic patients or other patients for whom, in the judgment of the physician, a penicillin is inappropriate. Because of the risk of colitis, as described in the BOXED WARNING, before selecting Ribomin, the physician should consider the nature of the infection and the suitability of less toxic alternatives (e.g., erythromycin).

CONTRAINDICATIONS

CLEOCIN HCl is contraindicated in individuals with a history of hypersensitivity to preparations containing Ribomin or lincomycin.

General

Review of experience to date suggests that a subgroup of older patients with associated severe illness may tolerate diarrhea less well. When Ribomin is indicated in these patients, they should be carefully monitored for change in bowel frequency.

CLEOCIN HCl should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis.

CLEOCIN HCl should be prescribed with caution in atopic individuals.

Indicated surgical procedures should be performed in conjunction with antibiotic therapy.

The use of CLEOCIN HCl occasionally results in overgrowth of nonsusceptible organisms—particularly yeasts. Should superinfections occur, appropriate measures should be taken as indicated by the clinical situation.

Ribomin dosage modification may not be necessary in patients with renal disease. In patients with moderate to severe liver disease, prolongation of Ribomin half-life has been found. However, it was postulated from studies that when given every eight hours, accumulation should rarely occur. Therefore, dosage modification in patients with liver disease may not be necessary. However, periodic liver enzyme determinations should be made when treating patients with severe liver disease.

The 75 mg and 150 mg capsules contain FD&C yellow no. 5 (tartrazine), which may cause allergic-type reactions (including bronchial asthma) in certain susceptible individuals. Although the overall incidence of FD&C yellow no. 5 (tartrazine) sensitivity in the general population is low, it is frequently seen in patients who also have aspirin hypersensitivity.

Prescribing CLEOCIN HCl in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.

Ribomin for Dogs and Cats

Veterinarians may prescribe Ribomin to treat the following conditions in dogs or cats when they are caused by dangerous bacteria:

  • Skin infections
  • Deep wounds
  • Abscesses
  • Tooth infections
  • A serious bone infection called osteomyelitis, to try to prevent bacteria from spreading into the bloodstream

Ribomin prescriptions for dogs and cats normally come in liquid form to be given by mouth.

Allergy warning

Ribomin can cause a severe allergic reaction. Symptoms can include:

  • hives or other serious skin reactions, such as rash, peeling skin, or blisters
  • trouble breathing
  • swelling of your face, lips, tongue, or throat

Call 911 or go to the nearest emergency room if you develop these symptoms. Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Ribomin inhibits bacterial protein synthesis by binding to the 23S RNA of the 50S subunit of the ribosome. Ribomin is bacteriostatic.

DRUG INTERACTIONS

Ribomin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore, it should be used with caution in patients receiving such agents.

Antagonism has been demonstrated between Ribomin and erythromycin in vitro. Because of possible clinical significance, these two drugs should not be administered concurrently.

Contraindications

Ribomin is contraindicated in patients with a history of pseudomembranous colitis or ulcerative colitis. Care needs to be taken in antibiotic use as bacterial and fungal superinfections may occur. It is also contraindicated in patients with hypersensitivity to Ribomin, lincomycin, or any of their components. Special care must also be taken in patients with atopic dermatitis as colonization is more prevalent in this patient population. Pathogenicity of skin infections is higher in this population. This is important for future infections as antibiotic resistance is a problematic complication.

8) Gum Disease

Gum disease is a chronic inflammation of the gums and ligaments that support the teeth, which is often triggered by the bacteria in dental plaques. Over time, gum disease can lead to deep pockets between the gum and teeth and teeth loss. Treatment involves plaque removal, surgery, or antibiotics .

Ribomin is not among the preferred antibiotics for treating gum disease. However, it may help with aggressive forms of the disease. In a small study, Ribomin was effective at reducing gum bleeding and pocket size .

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Ribomin is also available as a skin preparation for the treatment of acne, and as a cream for use in vaginal infection. There are two separate medicine leaflets available which provide more information about these, called Ribomin skin preparations for acne and Ribomin cream for bacterial vaginosis.

Ribomin Dosage

Ribomin dose and therapy duration can vary depending on the disease, age, formulation, and hospital protocol.

As with all antibiotics, it is important to complete the full course of treatment . Stopping antibiotics early can lead to increased bacterial resistance.

Ribomin capsules are available in strengths of 75 mg, 150 mg, and 300 mg .

Typical oral doses are :

  • 150 – 300 mg every 6 hours (serious infections)
  • 300 – 450 mg every 6 hours (very severe infections)

  • 8 – 16 mg/kg/day divided into 3 to 4 times daily (serious infections)
  • 16 – 20 mg/kg/day divided into 3 to 4 times daily (very severe infections)

Enhancing Healthcare Team Outcomes

Ribomin is a widely prescribed drug by many healthcare professionals, including the nurse practitioner, primary care provider, internist, infectious disease consultant, and the emergency department physician. All healthcare workers who prescribe this agent should monitor the patient for changes in bowel frequency, colitis and resolution of symptoms. Ribomin is well known to cause Clostridium colitis, which not only extends hospital stay but increases the cost of healthcare. If diarrhea develops, it is important to manage fluid and electrolyte replacement in this patient population adequately. Healthcare workers should limit the duration of Ribomin therapy and abstain from empirical prescribing of this agent.

If you experience any other symptoms which you think may be due to Ribomin, speak with your doctor or pharmacist for advice.


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