Quiflural

Quiflural

  • Active Ingredient: Ofloxacin
  • 400 mg, 200 mg
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What is Quiflural?

The active ingredient of Quiflural brand is ofloxacin. Ofloxacin is a fluoroquinolone (flor-o-KWIN-o-lone) antibiotic that fights bacteria in the body. Ofloxacin, USP is an off-white to pale yellow crystalline powder. The molecule exists as a zwitterion at the pH conditions in the small intestine. The relative solubility characteristics of Ofloxacin, USP at room temperature, as defined by USP nomenclature, indicate that Ofloxacin, USP is considered to be soluble in aqueous solutions with pH between 2 and 5. It is sparingly to slightly soluble in aqueous solutions with pH 7 (solubility falls to 4 mg/mL) and freely soluble in aqueous solutions with pH above 9. Ofloxacin, USP has the potential to form stable coordination compounds with many metal ions. This in vitro chelation potential has the following formation order: Fe +3 > Al +3 > Cu +2 > Ni +2 > Pb +2 > Zn +2 > Mg +2 > Ca +2 > Ba +2.

Used for

Quiflural is used to treat diseases such as: Anthrax, Anthrax Prophylaxis, Bladder Infection, Bone infection, Bronchitis, Campylobacter Gastroenteritis, Cervicitis, Chancroid, Chlamydia Infection, Epididymitis, Non-Specific, Epididymitis, Sexually Transmitted, Gonococcal Infection, Disseminated, Gonococcal Infection, Uncomplicated, Joint Infection, Kidney Infections, Methicillin-Resistant Staphylococcus Aureus Infection, Mycobacterium avium-intracellulare, Treatment, Nongonococcal Urethritis, Pelvic Inflammatory Disease, Plague, Pneumonia, Prostatitis, Salmonella Enteric Fever, Salmonella Gastroenteritis, Shigellosis, Skin or Soft Tissue Infection, Traveler's Diarrhea, Tuberculosis, Active, Urinary Tract Infection.

Side Effect

Possible side effects of Quiflural include: slurred speech; seeing, hearing, or feeling things that are not there; coma; cool, pale skin; increased hunger; muscle spasm or jerking of all extremities; unusual tiredness or weakness.

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Other uses for this medicine

Quiflural is also sometimes used to treat other types of infection, including Legionnaires' disease (type of lung infection), certain sexually transmitted diseases, infections of the bones and joints and of the stomach and intestines. Quiflural may also be used to treat or prevent anthrax or plague (serious infections that may be spread on purpose as part of a bioterror attack) in people who may have been exposed to the germs that cause these infections in the air. Quiflural may also be used to treat or prevent travelers' diarrhea in certain patients. Talk to your doctor about the risks of using Quiflural to treat your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Missed Dose of Quiflural

If you miss a dose of Quiflural, take it as soon as you remember.

But if it's almost time for your next dose, skip the missed dose and continue with your regular medication schedule.

Don't double up on doses to make up for a missed one.

Don't take more than two doses of oral Quiflural in one day.

Which drugs or supplements interact with Quiflural?

Quiflural reduces the elimination of theophylline, elevating blood levels of theophylline. (Theophylline is used to open airways in the treatment of asthma.) If concurrent use of Quiflural and theophylline cannot be avoided, frequent blood tests to monitor theophylline blood levels should be performed. Quiflural can enhance the action of the anticoagulant (blood thinner) warfarin (Coumadin), and increase the risk of bleeding. Both high and low blood sugar levels have been reported, especially in patients with diabetes who were also receiving insulin or other medications used to lower the blood sugar. Careful monitoring of blood sugar levels is recommended. Sucralfate (Carafate), iron, multivitamins containing zinc, didanosine (Videx), as well as antacids containing calcium, magnesium, or aluminum should not be taken within two hours before or after taking Quiflural.

Before taking this medicine

You should not use this medicine if you are allergic to Quiflural or other fluoroquinolones (ciprQuiflural, gemifloxacin, levQuiflural, moxifloxacin, norfloxacin, and others).

Quiflural may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. This can happen during treatment or up to several months after you stop taking Quiflural. Tendon problems may be more likely in certain people (children and older adults, or people who use steroid medicine or have had an organ transplant).

Tell your doctor if you have ever had:

tendon problems, bone problems, arthritis, or other joint problems;

blood circulation problems, aneurysm, narrowing or hardening of the arteries;

a genetic disease such as Marfan syndrome or Ehler's-Danlos syndrome;

a muscle or nerve disorder, such as myasthenia gravis;

liver or kidney disease;

long QT syndrome (in you or a family member); or

low levels of potassium in your blood (hypokalemia).

Quiflural is not approved for use by anyone younger than 18 years old.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

You should not breast-feed while using this medicine.

General

As with other anti-infectives, prolonged use may result in overgrowth of non susceptible organisms, including fungi. If super infection occurs discontinue use and institute alternative therapy. Whenever clinical judgment dictates, the patient should be examined with the aid of magnification, such as slit lamp biomicroscopy and, where appropriate, fluorescein staining. Quiflural should be discontinued at the first appearance of a skin rash or any other sign of hypersensitivity reaction.

The systemic administration of quinolones, including Quiflural, has led to lesions or erosions of the cartilage in weight-bearing joints and other signs of arthropathy in immature animals of various species. Quiflural, administered systemically at 10 mg/kg/day in young dogs (equivalent to 110 times the maximum recommended daily adult ophthalmic dose) has been associated with these types of effects.

How to use Quiflural eye drops

  1. Wash your hands well before you use the drops.
  2. Remove the cap.
  3. Tilt your head back a little and pull the lower l >

INDICATIONS

Quiflural ophthalmic solution is indicated for the treatment of infections caused by susceptible strains of the following bacteria in the conditions listed below:

Pediatric Use

Safety and effectiveness in infants below the age of one year have not been established. Quinolones, including Quiflural, have been shown to cause arthropathy in immature animals after oral administration; however, topical ocular administration of Quiflural to immature animals has not shown any arthropathy. There is no evidence that the ophthalmic dosage form of Quiflural has any effect on weight bearing joints.

Quiflural Pictures

By Lynn Marks | Medically Reviewed by Robert Jasmer, MD

Latest Update: 2016-03-28 Copyright © 2014 Everyday Health Media, LLC

What Is Quiflural Ophthalmic?

Quiflural is a fluoroquinolone (flor-o-KWIN-o-lone) antibiotic that fights bacteria in the body.

Quiflural ophthalmic (for use in the eyes) is used to treat bacterial infections of the eyes.

Quiflural ophthalmic is also used to treat an ulcer in the cornea of the eye.

Quiflural will not treat a viral or fungal infection of the eye.

Quiflural ophthalmic may also be used for purposes not listed in this medication guide.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

You should not use this medicine if you are allergic to Quiflural or other fluoroquinolones (ciprQuiflural, gemifloxacin, levQuiflural, moxifloxacin, norfloxacin, and others).

Do not use this medicine to treat a viral or fungal infection in the eye. Quiflural ophthalmic is for use in treating only bacterial infections of the eye.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether Quiflural ophthalmic passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

Quiflural eye drops (solution) are not approved for use by anyone younger than 1 year old.

What other drugs will affect Quiflural?

Some medicines can make Quiflural much less effective when taken at the same time. If you take any of the following medicines, take your Quiflural dose 2 hours before or 2 hours after you take the other medicine.

antacids that contain calcium, magnesium, or aluminum (such as Amphojel, Di-Gel Maalox, Milk of Magnesia, Mylanta, Pepcid Complete, Rolaids, Rulox, Tums, and others), or the ulcer medicine sucralfate (Carafate);

didanosine (Videx) powder or chewable tablets; or

vitamin or mineral supplements that contain calcium, iron, magnesium, or zinc.

Tell your doctor about all your other medicines, especially:

a diuretic or "water pill";

insulin or oral diabetes medicine (check your blood sugar regularly);

heart rhythm medication;

medicine to treat depression or mental illness;

steroid medicine (such as prednisone); or

This list is not complete. Other drugs may affect Quiflural, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Pregnancy and Quiflural

It's not known whether Quiflural can harm an unborn baby.

Tell your doctor if you're pregnant, or might become pregnant, before taking this medicine.

It's also not known whether this drug can harm a breastfeeding baby. Don't breastfeed while taking Quiflural.

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

  • skin rash
  • hives
  • itching
  • difficulty breathing or swallowing
  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

Quiflural eye drops may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Quiflural Interactions

Tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking, especially those listed in the Quiflural Warnings section above, and any of the following:

  • Other antibiotics
  • Antacids containing aluminum, calcium, or magnesium (includes Maalox, Mylanta, Tums, and others)
  • Anticoagulants (blood thinners) such as Coumadin or Jantoven (warfarin)
  • Certain antidepressants
  • Antipsychotics (drugs to treat mental illness)
  • Tagamet (Cimetidine)
  • Gengraf, Neoral, or Sandimmune (cyclosporine)
  • Videx (didanosine)
  • Diuretics (water pills)
  • Insulin and oral medications for diabetes
  • Certain drugs for irregular heartbeat, such as quinidine, Cordarone (amiodarone), Procanbid (procainamide), or Betapace, Betapace AF, or Sorine (sotalol)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as Advil or Motrin (ibuprofen) or Aleve (naproxen)
  • Probalan (probenecid) or Col-Probenecid (colchicine and probenecid)
  • Carafate (sucralfate)
  • Supplements or multivitamins containing iron or zinc
  • Elixophyllin, Theo-24, or Uniphyl (theophylline)

Short-Term Effects

  • See "What Are Side Effects Associated with Using Quiflural?"

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