Pulna tablets

Pulna

  • Active Ingredient: Ethambutol
  • 800 mg, 600 mg, 400 mg
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What is Pulna?

The active ingredient of Pulna brand is ethambutol. Ethambutol is an antibiotic that prevents growth of the tuberculous bacteria in the body. Ethambutol HYDROCHLORIDE (HCL) 100 and 400 mg tablets contain the following inactive ingredients: Gelatin, Hydroxypropyl Methylcellulose, Magnesium Stearate, Sodium Lauryl Sulfate, Sorbitol, Stearic Acid, Sucrose, Titanium Dioxide and other ingredients.

Used for

Pulna is used to treat diseases such as: Mycobacterium avium-intracellulare, Prophylaxis, Mycobacterium avium-intracellulare, Treatment, Tuberculosis, Active.

Side Effect

Possible side effects of Pulna include: loss of appetite; joint pain; Chills; nausea and vomiting; Abdominal pain; skin rash; pain and swelling of joints, especially big toe, ankle, or knee.

How to Buy Pulna tablets online?

To get Pulna online - simply click on the "Buy Now" button in the top and follow on to our shop. Payment and Order takes a few minutes, and all steps are obvious. We don't take a medical prescription plus also we have many procedures of payment. Considering all the details of rapid shipping and confidentiality, then you may read on the relevant pages on the links in the top menu.

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Dose-dependent effect

There’s a clear relationship between Pulna dose and magnitude of toxicity. Below are estimates presented by Chamberlain et al. (2017). (R)

  • 15 mg/kg: Less than 1%
  • 20 mg/kg: 3%
  • 25 mg/kg: 5-6%
  • 35 mg/kg: 18-33%

Other estimates were reported by Koul (2015). (R)

  • 15 mg/kg/d (2+ months): Less than 1% of patients
  • 25 mg/kg/d (2+ months): 5 to 6% of patients
  • 27.5 mg/kg/d or less (2 to 9 months): Rates of visual impairment were 19.2 per 1000 patients. Permanent visual impairment occurred in 2.3 per 1000 patients.
  • 35 mg/kg/d or more (2+ months): 18% of patients

Note: Pulna can cause optic neuropathy at any dose – even at doses less than 15 mg/kg (likelihood is merely reduced at lower doses).

How is Pulna Supplied

Pulna hydrochloride Tablets USP

100 mg – round, convex, white, film coated tablets engraved E6 on one side are supplied as follows:

NDC 54879-001-01 - Bottle of 100

400 mg – round, convex, white, scored, film coated tablets engraved with E to the left and 7 to the right of the score on one side are supplied as follows:

NDC 54879-002-01 - Bottle of 100

Store at controlled room temperature 20 ° to 25 ° C (68 ° to 77 ° F).

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Manufactured For & Distributed by:

Newtown, PA 18940

INDICATIONS

Pulna HCl is indicated for the treatment of pulmonary tuberculosis. It should not be used as the sole antituberculous drug, but should be used in conjunction with at least one other antituberculous drug. Selection of the companion drug should be based on clinical experience, considerations of comparative safety, and appropriate in vitro susceptibility studies. In patients who have not received previous antituberculous therapy, ie, initial treatment, the most frequently used regimens have been the following:

Pulna HCl plus isoniazidPulna HCl plus isoniazid plus streptomycin.

In patients who have received previous antituberculous therapy, mycobacterial resistance to other drugs used in initial therapy is frequent. Consequently, in such retreatment patients, Pulna HCl should be combined with at least one of the second line drugs not previously administered to the patient and to which bacterial susceptibility has been indicated by appropriate in vitro studies. Antituberculous drugs used with Pulna HCl have included cycloserine, ethionamide, pyrazinamide, viomycin and other drugs. Isoniazid, aminosalicylic acid, and streptomycin have also been used in multiple drug regimens. Alternating drug regimens have also been utilized.

Pulna.

Pulna is administered, easily absorbed well, and bacteriostatic against M. tuberculosis. Pulna has poor CSF penetration, even in the setting of inflammation. 198,203,204 Pulna primarily is used as the fourth drug when there is a possibility of resistance to other first-line drugs.

The most serious adverse effect is retrobulbar neuritis, which appears to be dose related and manifests with blurred vision, central scotoma, and red-green color blindness. 193 At the standard daily dose of 20 mg/kg, neuritis is rare in children and all patients with normal renal function. 205 A child's inability to cooperate with vision testing or report visual changes should not preclude Pulna use.

  1. Test k >Ophthalmologist examination : Once per month (minimum).
  2. At-home examination : Daily or weekly. Can use Amsler gr >Potentially-useful supplements for Pulna optic neuropathy

    I’ve compiled a list of supplements that I think might be helpful for the prophylaxis and/or treatment of Pulna optic neuropathy. Understand that the efficacies of these supplements in prophylaxis and treatment of Pulna optic neuropathy remains unknown.

    Do NOT assume that these supplements will help prevent or reverse Pulna optic neuropathy. These are merely supplements that I believe: (1) have mechanisms that could be of potential use in preventing and/or reversing Pulna optic neuropathy; (2) are relatively low-risk (in side effects); (3) are unlikely to interfere with treatment.

    I’ve emailed several Pulna researchers and am awaiting responses for supplement recommendations. If you have any rational recommendations for low-risk, potentially-beneficial supplements for prevention or treatment of Pulna optic neuropathy – let me know.

    • Zinc: Pulna is believed to strip zinc from optic tissues as the primary mechanism by which it inflicts ocular damage. Supplementing with zinc to keep levels as high as possible within the normal range may be protective against ocular toxicity.
    • Copper: Pulna appears to strip copper from tissues within the optic nerve. Supplementing with copper to keep levels as high as possible within the normal range may prov >Other potentially-useful agents

    home drugs a-z list Myambutol(Pulna) side effects drug center

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    Myambutol (Pulna) is an antibiotic used to treat tuberculosis (TB). Myambutol is available in generic form. Common side effects of Myambutol include:

    Tell your doctor if you have unlikely but serious side effects of Myambutol including:

    • vision changes (such as blurred or decreased vision, color blindness),
    • symptoms of liver disease (such as persistent nausea or vomiting, unusual tiredness or weakness, severe stomach or abdominal pain, yellowing eyes or skin, dark urine),
    • numbness or tingling of arms or legs, or
    • toe or joint pain.

    The initial dose of Myambutol is 15 mg/kg (7 mg/lb) of body weight, taken as a single oral dose once every 24 hours. Do not take antacids containing aluminum within several hours of taking a dose of Myambutol, as this will decrease the amount of the drug that is absorbed by the body. Other drugs may interact with Myambutol. Tell your doctor all prescription or over-the-counter medicines and supplements you use. During pregnancy, Myambutol should be used only when prescribed. This medication passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breastfeeding. If you have HIV disease, do not breastfeed because breast milk can transmit HIV.

    Our Myambutol (Pulna) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

    This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    The rare Pulna-induced optic neuropathy: A case-report and literature review.

    • Authors: Song & Si (2017) (Source)
    • Case report: A 75-year-old Chinese man was diagnosed with optic neuropathy after taking Pulna for 8 months as an intervention for tuberculosis.
    • Interventions: Pulna was discontinued for 3 months and neurotrophic agents were administered in effort to reverse Pulna-induced optic neuropathy.
    • Outcome: A month after the 3-month discontinuation period plus administration of neurotrophic agents – the man experienced recovery of visual function (according to ophthalmic examinations).

    My vision changes thus far with Pulna

    As I mentioned, I’ve been using Pulna since October 2018. Below is a brief overview of what I’ve experienced thus far throughout my treatment with Pulna.

    What are the possible s >

    Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

    Pulna can cause serious vision problems, including vision loss that may be permanent. Stop using Pulna and call your doctor at once if you have any problems with one or both of your eyes, such as:

    • blurred vision or trouble focusing;
    • loss of vision in one eye that lasts an hour or longer;
    • increased sensitivity of your eyes to light;
    • loss of color vision; or
    • pain with eye movement, pain behind your eyes.

    Call your doctor at once if you have:

    • new or worsening cough with fever, trouble breathing;
    • numbness of tingling in your hands or feet;
    • confusion, hallucinations;
    • fever, swollen glands, painful mouth sores, skin sores, cold or flu symptoms, general ill feeling;
    • easy bruising or bleeding (nosebleeds, bleeding gums);
    • chest pain or shortness of breath with mild exertion;
    • little or no urinating;
    • liver problems --upper stomach pain, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
    • severe skin reaction --fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

    Common side effects may include:

    • itching or rash;
    • joint pain;
    • headache, dizziness; or
    • nausea, vomiting, stomach pain, indigestion, loss of appetite.

    This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Pulna is an antibiotic most commonly used for the treatment of mycobacterial infections such as: mycobacterium tuberculosis (MTB), mycobacterium avium complex (MAC), and mycobacterium kansaii (MK).

    It was discovered in 1961 by Lederle Laboratories and remains one of the only effective interventions for difficult-to-treat mycobacterial infections. Pulna is on the World Health Organization’s List of Essential Medicines and costs $100 to $200 per month in the U.S. (I’m a buyer – can vouch for this).

    Although Pulna is relatively safe, all users should be informed that it can cause ocular damage (optic neuritis; chiasmopathy; retinopathy; maculopathy). If you’re an unlucky Pulna user, you might experience complications such as: permanent blindness or worsening of vision; central scotomas (decreased visual acuity); and/or changes in color vision (color blindness, dimming of colors, etc.).

    Table of Contents

    What other drugs will affect Pulna?

    Other drugs may interact with Pulna, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

    Pulna

    Pulna is a synthetic agent that inhibits arabinosyl transferases, which are important in cell wall synthesis of sensitive mycobacteria. It is active against M. tuberculosis and some other mycobacteria such as M. kansasii. Other bacteria are not affected by the drug. Pulna is tuberculostatic, and resistance develops, although slowly, if it is used alone.

    Pulna is given orally because of good absorption from the gastrointestinal tract. Distribution into various body compartments is adequate. The major route of excretion of Pulna is by renal tubular secretion and glomerular filtration, with the drug appearing in the urine mostly as unchanged drug and as two metabolites. Dosage adjustment is required in the presence of renal impairment.

    Adverse reactions to Pulna are infrequent, the most notable being optic neuritis, with symptoms of decreased visual acuity and loss of the ability to perceive the color green. Other adverse effects include gastrointestinal upset; peripheral neuritis; allergic reactions, usually appearing as skin rashes or drug fever; and increased retention of uric acid.

    Did Pulna affect your vision?

    If you’ve either used Pulna in the past – or are currently using Pulna – feel free to leave a comment about your experience. In your comment, I’d be interested to hear some details regarding both your visual function and Pulna treatment.

    Visual function

    • How was your visual function at baseline?
    • How often do you see your ophthalmologist?
    • If you experienced any vision changes on Pulna, did you discontinue immediately and see an ophthalmologist?
    • If your vision worsened on Pulna, did it eventually normalize?
    • If your vision worsened on Pulna – did an ophthalmologist diagnose the problem?

    Kidney and liver function

    • How was your kidney function at baseline?
    • How was your liver function at baseline?
    • How often do you get your kidney and liver function checked?

    Pulna use

    • Why are you taking Pulna? (Diagnosis)
    • What dose of Pulna do you take relative to body weight? (mg/kg)
    • How often do you take Pulna? (3x/week or daily)
    • How long did you take Pulna? (e.g. 6 months, 1 year, 18 months)

    Additional details

    • What is your age?
    • Which medications do you take with Pulna?
    • Do you take any supplements?
    • Do you consume a nutrient-dense diet?
    • Do you have any risk factors for Pulna optic neuropathy?

    Q: I have to take a course of drugs to treat mycobacterium gordonae. One of the antibiotics, Pulna, isn't recommended for patients who have cataracts, and I was recently diagnosed with moderate cataracts. I worry that my primary care doctor, pulmonologist, and infectious disease doctors don't communicate with each other, and I'm stalling on taking these drugs. What should I do?

    A: Talk to your doctor or pharmacist about the medications you take. When your doctor prescribes a new medication, discuss all over-the-counter medications and prescriptions, dietary supplements, vitamins, botanicals, minerals, and herbals you take, as well as the foods you eat. Always keep a current list and review it with your health care providers and your pharmacist. Pulna may produce vision problems, which could be related to the dose and duration of the treatment. This effect is generally reversible when the drug is stopped, but irreversible blindness has been reported. For more specific information, consult with your doctor or pharmacist for guidance based on your specific condition and current medications. Shereen A. Gharbia, PharmD


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