Pharxacin

Pharxacin

  • Active Ingredient: Ofloxacin
  • 400 mg, 200 mg
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What is Pharxacin?

The active ingredient of Pharxacin brand is ofloxacin. Ofloxacin is a fluoroquinolone (flor-o-KWIN-o-lone) antibiotic that fights bacteria in the body. Ofloxacin, USP is an off-white to pale yellow crystalline powder. The molecule exists as a zwitterion at the pH conditions in the small intestine. The relative solubility characteristics of Ofloxacin, USP at room temperature, as defined by USP nomenclature, indicate that Ofloxacin, USP is considered to be soluble in aqueous solutions with pH between 2 and 5. It is sparingly to slightly soluble in aqueous solutions with pH 7 (solubility falls to 4 mg/mL) and freely soluble in aqueous solutions with pH above 9. Ofloxacin, USP has the potential to form stable coordination compounds with many metal ions. This in vitro chelation potential has the following formation order: Fe +3 > Al +3 > Cu +2 > Ni +2 > Pb +2 > Zn +2 > Mg +2 > Ca +2 > Ba +2.

Used for

Pharxacin is used to treat diseases such as: Anthrax, Anthrax Prophylaxis, Bladder Infection, Bone infection, Bronchitis, Campylobacter Gastroenteritis, Cervicitis, Chancroid, Chlamydia Infection, Epididymitis, Non-Specific, Epididymitis, Sexually Transmitted, Gonococcal Infection, Disseminated, Gonococcal Infection, Uncomplicated, Joint Infection, Kidney Infections, Methicillin-Resistant Staphylococcus Aureus Infection, Mycobacterium avium-intracellulare, Treatment, Nongonococcal Urethritis, Pelvic Inflammatory Disease, Plague, Pneumonia, Prostatitis, Salmonella Enteric Fever, Salmonella Gastroenteritis, Shigellosis, Skin or Soft Tissue Infection, Traveler's Diarrhea, Tuberculosis, Active, Urinary Tract Infection.

Side Effect

Possible side effects of Pharxacin include: bloating; numbness of the hands; troubled breathing with exertion; passing gas; decreased hearing or any change in hearing.

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Pharmacokinetics

Serum, urine and tear concentrations of Pharxacin were measured in 30 healthy women at various time points during a ten-day course of treatment with Pharxacin ophthalmic solution. The mean serum Pharxacin concentration ranged from 0.4 ng/mL to 1.9 ng/mL Maximum Pharxacin concentration increased from 1.1 ng/mL on day one to 1.9 ng/mL on day 11 after QID dosing for 10 1/2 days. Maximum serum Pharxacin concentrations after ten days of topical ophthalmic dosing were more than 1000 times lower than those reported after standard oral doses of Pharxacin.

Tear Pharxacin concentrations ranged from 5.7 to 31 µg/g during the 40 minute period following the last dose on day 11. Mean tear concentration measured four hours after topical ophthalmic dosing was 9.2 µg/g.

Corneal tissue concentrations of 4.4 µg/mL were observed four hours after beginning topical ocular application of two drops of Pharxacin ophthalmic solution every 30 minutes. Pharxacin was excreted in the urine primarily unmodified.

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

  • skin rash
  • hives
  • itching
  • difficulty breathing or swallowing
  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

Pharxacin eye drops may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Pharxacin Ophthalmic S >

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe burning, stinging, or irritation after using this medicine;
  • eye pain;
  • eye swelling, redness, severe discomfort, crusting or drainage (may be signs of infection); or
  • severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

  • blurred vision;
  • eye pain or
  • mild burning, stinging, or other discomfort;
  • eye redness, itching, or watering;
  • red or puffy eyelids;
  • your eyes being more sensitive to light; or
  • eye dryness, feeling like something is in your eye.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What do I need to tell my doctor BEFORE I take Pharxacin?

  • If you have an allergy to Pharxacin or any other part of Pharxacin (ophthalmic).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you are breast-feeding or plan to breast-feed.

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Pharxacin (ophthalmic) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

Pharxacin Dosage

Oral form: Oral Pharxacin comes as a tablet. It's typically taken by mouth twice a day, for three days to six weeks.

The medicine can be taken with or without food. Try to take it around the same time each day.

Your dose and length of treatment will depend on the type of infection you have.

Follow the instructions on your prescription label carefully. Don't take more or less Pharxacin than is recommended.

Be sure to drink plenty of water while taking oral Pharxacin.

Ear drops: Pharxacin ear drops come as a liquid drop to apply to the opening of the ear canal. They're usually taken once or twice a day, for 7 to 14 days.

Try to use take medicine around the same time each day.

Use Pharxacin ear drops exactly as directed. Don't take more or less of the medicine than is prescribed by your doctor.

Don't use Pharxacin ear drops in your eyes.

Eye drops: Pharxacin eye drops come as a liquid drop to apply to the eye. They're usually taken in the affected eye four or more times a day.

Wash your hands before and after taking Pharxacin eye drops. Try to take them around the same time each day.

Follow the instructions on your product label carefully when using the drops.

Remove your contact lenses before taking Pharxacin eye drops. You can put them back in 10 minutes after you give yourself a dose.

Don't swallow Pharxacin eye drops.

What Is Pharxacin and How Does It Work?

Pharxacin is a broad-spectrum fluoroquinolone antibiotic used to treat bacterial infections that cause bronchitis, pneumonia, chlamydia, gonorrhea, skin infections, urinary tract infections, and infections of the prostate.

Pharxacin is available under the following different brand names: Floxin.

What should I avoid while taking Pharxacin?

Avoid driving or hazardous activity until you know how Pharxacin will affect you. Your reactions could be impaired.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

Pharxacin could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Tell your doctor if you have severe burning, redness, itching, rash, or swelling after being in the sun.

What are some things I need to know or do while I take Pharxacin?

  • Tell all of your health care providers that you take Pharxacin (ophthalmic). This includes your doctors, nurses, pharmacists, and dentists.
  • Use care when driving or doing other tasks that call for clear eyesight.
  • Bright lights may bother you. Wear sunglasses.
  • Do not use longer than you have been told. A second infection may happen.
  • Very bad and sometimes deadly allergic reactions have rarely happened with other forms of Pharxacin (ophthalmic) as well as drugs like this one. Talk with the doctor.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Pharxacin (ophthalmic) while you are pregnant.

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