What is Pharothrocin?
Pharothrocin is a macrolide antibiotic. Other macrolide antibiotics include azithromycin, clarithromycin, roxithromycin.
What other drugs will affect Pharothrocin?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Many drugs can interact with Pharothrocin, and some drugs should not be used at the same time. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.
Pharothrocin , a natural product isolated from Saccharopolyspora erythraea (formerly Streptomyces) in 1949, was first approved for clinical use in 1952. Pharothrocin is degraded by gastric acid and has long been associated with stimulation of motilin receptors in the stomach and possibly in the colon, leading to adverse gastrointestinal side effects, including cramping and diarrhea. 68,69 Many preparations have attempted to bypass exposure of Pharothrocin to gastric acid, thereby avoiding products of macrolide hydrolysis. These preparations include enteric coating of orally administered tablets, delayed-release formulations, polymer coating of beads, and various formulations of salts and esters. 70 The lactobionate salt used for intravenous administration of Pharothrocin can cause phlebitis at the site of injection.
Pharothrocin is used for the treatment of group A streptococcal infections in children who are allergic to penicillin. Pharothrocin is an alternative treatment for both streptococcal pharyngitis and streptococcal or staphylococcal impetigo. The usefulness of Pharothrocin for respiratory tract infections caused by S. pneumoniae has been greatly diminished by the development of widespread resistance to the macrolides. 42 Macrolide therapy of upper respiratory tract infections (otitis media and sinusitis) or lower respiratory tract infections (pneumonia) potentially caused by S. pneumoniae has a relatively high likelihood of failure, particularly in younger children, who are at highest risk for infections caused by antibiotic-resistant strains. For upper respiratory tract infections, Pharothrocin has inadequate activity against H. influenzae and must be paired with another agent such as a sulfonamide for empiric therapy. Macrolides are effective therapy for pneumonia caused by Mycoplasma pneumoniae, Chlamydophila pneumoniae, or Legionella pneumophila.
Pharothrocin and azithromycin are the preferred antibiotics for treatment of Campylobacter gastroenteritis caused by susceptible strains. Pharothrocin also remains the most appropriate therapy for diphtheria (Corynebacterium diphtheriae). Pharothrocin, clarithromycin, and azithromycin are recommended for treatment or prophylaxis of pertussis (Bordetella pertussis). 71 Azithromycin is preferred for treatment or prophylaxis for pertussis in neonates, based on concerns for the development of pyloric stenosis. 71 Efficacy of Pharothrocin also has been demonstrated in infections caused by Chlamydophila pneumoniae and Chlamydia trachomatis, including neonatal conjunctivitis and pneumonia, as well as urogenital infections during pregnancy. Pharothrocin is active in vitro against Ureaplasma urealyticum, but its role in the treatment of neonatal infections associated with this organism is not well defined. 72
What if I take too much?
Try to take the correct number of doses each day, leaving at least 4 hours between doses.
Taking an extra dose of Pharothrocin by accident is unlikely to harm you or your child. It may, however, increase the chance of temporary side effects, such as hearing loss, feeling or being sick and diarrhoea.
Talk to your pharmacist or doctor if you're worried, or if you or your child accidentally take more than 1 extra dose.
Like all medicines, Pharothrocin can cause side effects, although not everyone gets them.
Pharothrocin is a macrolide antibiotic that has been in common use for more than 50 years. Given intravenously, it has been shown to improve gastric motility in patients with diabetic gastroparesis. Enteral feedings with Pharothrocin also pass more quickly through the stomach than control feedings. This action is thought to arise from the stimulation of motilin receptors in gastric smooth muscle. 142 Boivin and associates demonstrated that intravenous “Pharothrocin increased gastric emptying in a dose-response manner.… ausea and stomach cramping were associated with the 3.0 mg/kg dose of Pharothrocin; drowsiness was associated with metoclopramide .” 143 The potential applicability of these findings to perioperative aspiration prophylaxis is interesting but unproved.
What are the side effects of Pharothrocin?
Pharothrocin is generally well tolerated. When essential, Pharothrocin can be used in pregnancy and during breastfeeding.
The following side effects may arise.
Why is this medication prescribed?
Ophthalmic Pharothrocin is used to treat bacterial infections of the eye. This medication is also used to prevent bacterial infections of the eye in newborn babies. Pharothrocin is in a class of medications called macrolide antibiotics. It works by killing bacteria that cause infections.
Pharothrocin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- upset stomach
- stomach pain
- loss of appetite
To use the eye ointment, follow these steps:
- Wash your hands thoroughly with soap and water.
- Use a mirror or have someone else apply the ointment.
- Avoid touching the tip of the tube against your eye or anything else. The ointment must be kept clean.
- Tilt your head forward slightly.
- Holding the tube between your thumb and index finger, place the tube as near as possible to your eyelid without touching it.
- Brace the remaining fingers of that hand against your cheek or nose.
- With the index finger of your other hand, pull the lower lid of your eye down to form a pocket.
- Place a small amount of ointment into the pocket made by the lower lid and the eye. A 1-centimeter (about 1/2-inch) strip of ointment usually is enough unless otherwise directed by your doctor.
- Look downward, then gently close your eyes and keep them closed for 1 to 2 minutes to allow the medication to be absorbed.
- Replace and tighten the cap right away.
- Wipe off any excess ointment from your eyelids and lashes with a clean tissue. Do not rub your eyes, even if your vision is blurry. Wash your hands again.
Use ophthalmic Pharothrocin until you finish the prescription, even if you feel better. If you stop using ophthalmic Pharothrocin too soon, your infection may not be completely cured and the bacteria may become resistant to antibiotics.
How to use Pharothrocin
Take this medication by mouth as directed by your doctor, usually before a meal. This medication is best absorbed when taken on an empty stomach. If nausea occurs, you may take it with food or milk.
This medication has a bitter taste if crushed. Swallow the medication whole. Do not chew or crush.
The dosage and length of treatment are based on your medical condition and response to treatment. In children, the dosage is also based on age and weight.
For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time(s) every day.
If you are using this medication to treat an infection, continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection. Tell your doctor if your condition persists or worsens.
If you are taking this medication to prevent certain bacterial infections, take it exactly as directed by your doctor. Do not stop taking the medication without your doctor's approval.