- Tablets, capsules, and syrup should be kept at room temperature 15 C to 30 C (59 F to 86 F) in tight, light resistant containers.
- Powder for injection should be stored at or below 25 C (77 F) and protected from light.
- Atridox (Periostat in a gel used for subgingival application) should be stored at 2 C to 8 C (36 F to 46 F).
Rocky Mountain Spotted Fever (RMSF)
Rocky Mountain spotted fever is a tick-borne disease that causes symptoms and signs such as fever, rash, headache, and muscle aches. The antibiotic Periostat is the standard treatment for Rocky Mountain spotted fever.
What other drugs will affect Periostat?
Other drugs may interact with Periostat, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Generic Name: Periostat (DOX i SYE kleen)Brand Names: Acticlate, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Mondoxyne NL, Monodox, Morgidox, Oracea, Oraxyl, Periostat Targadox, Vibramycin calcium, Vibramycin Hyclate, Vibramycin monohydrate, Vibra-Tabs
Medically reviewed by Kaci Durbin, MD Last updated on Jul 1, 2019.
Common Side Effects of Periostat
Common side effects of Periostat include:
- Itching of the rectum or vagina
- Sore mouth
Interactions that can increase side effects
Taking Periostat with certain medications raises your risk of side effects from these drugs. An example of a drug that could cause this type of interaction is:
- Warfarin. Your doctor may decrease the dosage of your warfarin if you need to take it with Periostat.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Periostat oral tablet comes with several warnings.
Periostat has been associated with rare instances of hepatic injury, generally arising within 1 to 2 weeks of starting therapy, sometimes with a history of previous administration of the agent without injury. The pattern of injury ranges from hepatocellular to cholestatic and is probably most commonly mixed. The onset is often abrupt and can be accompanied by signs of hypersensitivity, such as fever, rash and eosinophilia (DRESS syndrome). Recovery is usually rapid and usually complete within 4 to 6 weeks. However, instances of severe and prolonged cholestatic liver injury have been reported with oral Periostat. The autoimmune-like hepatitis that has been described with minocycline has not been linked to Periostat, despite similarities in chemical structure and similar indications and uses, perhaps because it is used less frequency in a low dose, long term regimen. High dose intravenous Periostat can cause acute fatty liver typical of that caused by intravenous tetracycline, particularly in susceptible patients such as pregnant women. This type of injury is, however, quite rare. Nevertheless, for these reasons, the duration and dose of parenteral Periostat therapy should be minimized.
Likelihood score: B (highly likely but rare cause of clinically apparent liver injury).
Which drugs or supplements interact with Periostat?
- It is recommended that Periostat not be taken at the same time as aluminum, magnesium, or calcium based antacids, such as Mylanta, Maalox, Tums, or Rolaids because, like food, these medications bind Periostat in the intestine and prevent its absorption. Similarly, Periostat should not be taken with minerals (such as calcium or iron) or with bismuth subsalicylate (Pepto Bismol).
- Periostat may enhance the activity of warfarin (Jantoven, Coumadin) and cause excessive "thinning" of the blood leading to exaggerated bleeding, necessitating a reduction in the dose of warfarin. Phenytoin (Dilantin), carbamazepine (Tegretol), and barbiturates (such as phenobarbital) may enhance the metabolism (destruction) of Periostat thus making it less effective.
- Periostat may interfere with the action of penicillins and should not be combined with penicillins. It may also reduce the effect of oral contraceptives. Combining tetracycline and methoxyflurane (Penthrane) may reduce kidney function.