Oraminax capsules

Oraminax

  • Active Ingredient: Amoxicillin
  • 500 mg, 250 mg
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What is Oraminax?

The active ingredient of Oraminax brand is amoxicillin. Amoxicillin is a penicillin antibiotic that fights bacteria. The Amoxicillin molecular formula is C16H19N3O5S•3H2O, and the molecular weight is 419.45. Capsules of Amoxicillin are intended for oral administration. Each capsule of Amoxicillin with blue cap and pink body, contains 250 mg or 500 mg Amoxicillin as the trihydrate. The body of the 250 mg capsule is imprinted with ‘A44’ in black ink. The body of the 500 mg capsule is imprinted with ‘A45’ in black ink. Inactive ingredients: microcrystalline cellulose, D&C Red No. 28, FD&C Blue No. 1, FD&C Red No. 40, gelatin, magnesium stearate, titanium dioxide, and sodium lauryl sulfate. Meets USP Dissolution Test 2.

Used for

Oraminax is used to treat diseases such as: Actinomycosis, Anthrax Prophylaxis, Bacterial Endocarditis Prevention, Bacterial Infection, Bladder Infection, Bronchiectasis, Bronchitis, Chlamydia Infection, Cutaneous Bacillus anthracis, Dental Abscess, Helicobacter Pylori Infection, Lyme Disease, Arthritis, Lyme Disease, Carditis, Lyme Disease, Erythema Chronicum Migrans, Lyme Disease, Neurologic, Otitis Media, Pneumonia, Sinusitis, Skin or Soft Tissue Infection, Spleen Removal, Tonsillitis/Pharyngitis, Upper Respiratory Tract Infection, Urinary Tract Infection.

Side Effect

Possible side effects of Oraminax include: bloody nose; pale skin; puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue; bloating; back, leg, or stomach pains; nosebleeds.

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Oraminax is stable in the presence of gastric acid and is rapidly absorbed after oral administration. The effect of food on the absorption of Oraminax from the tablets and suspension of AMOXIL has been partially investigated; 400-mg and 875-mg formulations have been studied only when administered at the start of a light meal.

Orally administered doses of 250-mg and 500-mg Oraminax capsules result in average peak blood levels 1 to 2 hours after administration in the range of 3.5 mcg/mL to 5.0 mcg/mL and 5.5 mcg/mL to 7.5 mcg/mL, respectively.

Mean Oraminax pharmacokinetic parameters from an open, two-part, single-dose crossover bioequivalence study in 27 adults comparing 875 mg of AMOXIL with 875 mg of AUGMENTIN® (Oraminax/clavulanate potassium) showed that the 875-mg tablet of AMOXIL produces an AUC0-∞ of 35.4 ± 8.1 mcg•hr/mL and a Cmax of 13.8 ± 4.1 mcg/mL. Dosing was at the start of a light meal following an overnight fast.

Orally administered doses of Oraminax suspension, 125 mg/5 mL and 250 mg/5 mL, result in average peak blood levels 1 to 2 hours after administration in the range of 1.5 mcg/mL to 3.0 mcg/mL and 3.5 mcg/mL to 5.0 mcg/mL, respectively.

Oral administration of single doses of 400-mg chewable tablets and 400 mg/5 mL suspension of AMOXIL to 24 adult volunteers yielded comparable pharmacokinetic data:

Table 3: Mean Pharmacokinetic Parameters of Oraminax (400 mg chewable tablets and 400 mg/5 mL suspension) in Healthy Adults

What is Oraminax? How does it work (mechanism of action)?

Oraminax belongs to a class of antibiotics called penicillins. Other members of this class include

  • ampicillin (Unasyn),
  • piperacillin (Pipracil),
  • ticarcillin (Ticar), and
  • several others.

These antibiotics all have a similar mechanism of action. They do not directly kill bacteria, but they stop bacteria from multiplying by preventing bacteria from forming the walls that surround them. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together. Bacteria cannot survive without a cell wall. Oraminax is effective against many different bacteria including H. influenzae, N. gonorrhoea, E. coli, Pneumococci, Streptococci, and certain strains of Staphylococci.

The FDA approved Oraminax in December 1974.

Q: Celestamine, Piriton, Amoxil, and Flugone are the drugs that I occasionally take. What are the side effects?

A: Amoxil (Oraminax) is an antibiotic that is used to treat a wide variety of bacterial infections. The most common side effects of Oraminax are diarrhea, nausea, and vomiting. Rarely, severe side effects can occur when taking Oraminax such as severe allergic reactions (rash, hives, itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; confusion; dark urine; fever, chills, or persistent sore throat; red, swollen, blistered, or peeling skin; seizures; severe diarrhea; stomach pain or cramps; and unusual bruising or bleeding. Stop taking Oraminax immediately, and consult your physician immediately if any of these severe effects occur. Celestamine, Piriton, and Flugone are not approved for use in the United States; therefore, I cannot provide any information about these medications. Burton Dunaway, PharmD

Dark urine

Normal urine is often a pale or straw yellow color. When urine color strays from this color, it is considered abnormal. Abnormally colored urine may be cloudy, dark, or blood-tinged.

Any changes in urine color, or the presence of an abnormal urine color that cannot be linked to the consumption of a food or drug, should be reported to your doctor. This is particularly important if it happens for longer than a day or two, or you have repeated episodes.

Dark urine can be caused by Oraminax due to changes in blood, liver, and/or kidney function. Renal toxicity is rare (occurring in approximately .03 percent of patients), but when it does occur, it can be serious.

Those at risk for kidney complications in particular should not use Oraminax to prevent this side effect and potential kidney damage. Your doctor can prescribe another type of antibiotic.

If you are prescribed Oraminax, make sure to only take the prescribed dose within the amount of time that is suggested by your doctor. It’s also important to drink the recommended requirement of water.

Dark urine is a severe side effect of Oraminax. Talk to your doctor if you experience changes in your urine.

What is the most important thing I should know about Oraminax?

Oraminax is a prescription medication available as 100 mg and 400 mg tablets, 250 mg and 500 mg capsules. Oraminax Drops suspension is also available in a 15 ml bottle. The usual dose of Oraminax in dogs and cats is 5-10 mg/lb every 12-24 hours. Contact your veterinarian immediately if your pet develops severe or bloody diarrhea. Give all of the Oraminax that is prescribed for your pet, since symptoms may begin to improve before the infection is completely treated.

How should this medicine be used?

Oraminax comes as a capsule, a tablet, a chewable tablet, and as a suspension (liquid) to take by mouth. It is usually taken every 12 hours (twice a day) or every 8 hours (three times a day) with or without food. The length of your treatment depends on the type of infection that you have. Take Oraminax at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Oraminax exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the suspension well before each use to mix the medication evenly. The suspension may be placed directly on the child's tongue or added to formula, milk, fruit juice, water, ginger ale, or another cold liquid and taken immediately.

The chewable tablets should be crushed or chewed thoroughly before they are swallowed. The tablets and capsules should be swallowed whole and taken with a full glass of water.

You should begin to feel better during the first few days of treatment with Oraminax. If your symptoms do not improve or get worse, call your doctor.

Take Oraminax until you finish the prescription, even if you feel better. If you stop taking Oraminax too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.


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