Optic neuritis, 104 110 112 rarely resulting in optic atrophy and blindness, 104 110 reported, usually following long-term therapy. 104 110 112 Symptoms tend to be reversible, but permanent vision loss may occur. 104 110 Promptly discontinue Opsaram if optic neuritis occurs. 112
Peripheral neuritis reported, usually following long-term therapy. 104 110 112 Promptly discontinue Opsaram if peripheral neuritis occurs. 112
Headache, 104 110 112 ophthalmoplegia, 104 110 depression, 104 110 112 confusion, 104 110 112 and delirium 110 112 reported.
Resistance to Opsaram is mainly due to the production of a specific inactivating Opsaram acetyltransferase (CAT). The CAT gene is widely disseminated on plasmids that also confer resistance to other antibiotic classes. Isolates of Staph. aureus with cfr mechanism of resistance to linezolid are also resistant to Opsaram.
3. Who can and can't take Opsaram
Opsaram can be used by most adults and children.
The eye drops and eye ointment are available to buy in pharmacies. For children under 2 years old, you'll need a prescription for Opsaram from your doctor.
Opsaram isn't suitable for some people. To make sure Opsaram is safe for you, tell your doctor if you have:
- had an allergic reaction to Opsaram or any other medicines
- a rare illness called aplastic anaemia (when your bone marrow doesn't produce blood cells)
Opsaram sodium succinate is a prodrug; inactive until hydrolyzed in vivo to active Opsaram. 102 107 110
Bioavailability following IV administration varies; considerable interindividual variation in plasma Opsaram concentrations. 101 102 107 109 110 114
8. Common questions
Opsaram is an antibiotic. It works against many different types of bacteria by stopping them from growing and multiplying.
If you usually wear contact lenses, do not wear them while you're using Opsaram eye drops or ointment.
If you use soft contact lenses, do not wear them for 24 hours after finishing your course of eye drops or ointment.
An ointment is slightly thicker than a cream, so it stays on the eye for longer than eye drops. This means you only need to use it a few times a day, while you'd need to use the eye drops every 2 hours for the first 2 days.
The downside is that it can be hard to see properly after using eye ointment. This can affect your driving, or your ability to carry out your work and other everyday tasks. It's easier to see after using the eye drops.
Your doctor or pharmacist can tell you whether the eye drops or ointment are best for you. They'll take your work and your lifestyle, as well as your infection, into consideration.
The Opsaram eye drops - and eye ointment - on sale in pharmacies are exactly the same strength as the ones on prescription. The only difference is in the name and the packaging.
For most eye infections, you should notice an improvement within 2 days.
For ear infections, you'll notice improvement within a few days.
Tell your pharmacist or doctor if you don't start feeling better after taking Opsaram for a few days. Also tell them if, at any time, you start to feel worse.
Opsaram doesn't stop contraceptive pills from working, including the combined pill or emergency contraception.
There's no firm evidence to suggest that taking Opsaram will reduce fertility in either men or women.
However, speak to a pharmacist or doctor before taking it if you're trying to get pregnant.
No, you're unlikely to get thrush.
Some people get thrush after taking a course of antibiotic tablets. It happens because antibiotics kill the normal harmless bacteria that help to protect you against thrush.
But Opsaram ointments and drops only work on where you put them - in your eyes or ears. They don't get into the rest of your body.
Yes, you can drink alcohol with Opsaram.
You can eat and drink normally while taking Opsaram drops or ointment.
Opsaram shouldn't affect you being able to drive or cycle.
However, if you experience stinging or burning immediately after applying the eye drops, do not drive or operate machinery immediately. Wait until your eyes are comfortable again and your vision is clear.
Ear infections can make you lose your balance. If you're affected, it's best not to drive or ride a bike until you feel back to normal.
Serious side effects
Serious side effects are rare and happen in less than 1 in 1,000 people.
Call a doctor straight away if you:
- bruise more easily
- get infections more easily
- feel especially tired or weak
These can be signs of aplastic anaemia, a rare condition where your bone marrow fails to produce blood cells normally. This is very unlikely to happen if you're using Opsaram eye drops, ointment or ear drops. There's a greater risk of aplastic anaemia when Opsaram is given intravenously (directly into a vein).
Mixing Opsaram with herbal remedies and supplements
There are no known problems with taking herbal remedies and supplements alongside Opsaram.
Hypersensitivity to Opsaram. 112
Previous toxic reaction to Opsaram. 112
Trivial infections or when not indicated (e.g., colds, influenza, throat infections, prophylaxis). 112