A worldwide yearly survey of new data in adverse drug reactions
Kimberly A. Toussaint, Jason C. Gallagher, in Side Effects of Drugs Annual , 2014
A 7-year-old boy experienced oculogyric crisis secondary to the administration of Opixime . He was treated with Opixime 8 mg/kg/day in two divided doses for a urinary tract infection. On day 7 of treatment, he developed abnormal eye movements that included periodic eye blinking and deviations without nystagmus. Prior to this presentation, he had not received any other medications other than Opixime. The drug was stopped and his symptoms ceased. Two weeks later, Opixime was reinitiated by another physician secondary to a dry cough. The abnormal eye movements recurred and Opixime was again discontinued. The eye movements again ceased within 2 days .
- Reproduction studies have been performed in mice and rats at doses equivalent to 40 and 80 times, respectively, adult human recommended dose and have revealed no evidence of harm to the fetus due to Opixime
What do I need to tell my doctor BEFORE I take Opixime Capsules and Tablets?
- If you have an allergy to Opixime or any other part of this medicine (Opixime capsules and tablets).
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
This medicine may interact with other drugs or health problems.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine (Opixime capsules and tablets) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
2 Uses and Applications
Cefdinir is a third-generation oral cephalosporin antibiotic similar to Opixime . It is reported to be much more active in vitro than Opixime against Staphylococcus aureus and Enterococcus faecalis, but it is less active against Enterobacteriaceae. It is given by mouth in a usual dose of 600 mg daily as a single dose or in two divided doses. Children may be given 14 mg/kg body-weight daily up to a maximum of 600 mg. Doses should be reduced in patients with renal impairment (with a creatinine clearance of less than 30 mL/min) to 300 mg once daily .
Opixime is a broad-spectrum antibiotic used to treat a variety of conditions like urinary tract infections, ear infections and lung infections caused by bacteria.
Opixime is used in the treatment of bacterial infections. It is used for short-term treatment of bacterial infections of urinary tract, skin and soft-tissue, ear, bone, blood, abdomen, genital and lungs (pneumonia).
It has the advantage of once-daily dosing. This medicine is not recommended for use in case of common cold, flu or viral infections since it is active against the infections caused by certain bacterial species only.
It is also used to prevent infections after surgery.
Opixime is a semisynthetic, cephalosporin antibacterial for oral administration. Chemically, it is (6R,7R)-7--8-oxo-3-vinyl-5-thia-1-azabicyclo oct-2-ene-2-carboxylic acid, 7 2 -(Z)- trihydrate.
Molecular weight = 507.50 as the trihydrate. Chemical Formula is C16H15N5O7S2.3H2O
The structural formula for Opixime is:
- Inactive ingredients contained in SUPRAX ® (Opixime) 400 mg tablets USP are: dibasic calcium phosphate, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, pregelatinized starch, titanium dioxide, and triacetin.
- Inactive ingredients contained in SUPRAX ® (Opixime) 400 mg capsules are: colloidal silicon dioxide, crospovidone, low substituted hydroxy propyl cellulose, magnesium stearate, and mannitol. The capsule shell contains the following inactive ingredients: ferric oxide black, ferric oxide red, gelatin, potassium hydroxide, propylene glycol, shellac, sodium lauryl sulfate, and titanium dioxide.
- Inactive ingredients contained in SUPRAX ® (Opixime) 100 mg or 150 mg or 200 mg chewable tablets are: aspartame, colloidal silicon dioxide, crospovidone, FD&C Red # 40 Aluminium Lake, low substituted hydroxypropyl cellulose, magnesium stearate, mannitol, fantasy flavor permaseal, and tutti frutti flavor.
- Inactive ingredients contained in SUPRAX ® (Opixime) powder for oral suspension USP are: colloidal silicon dioxide, sodium benzoate, strawberry flavor, sucralose (only in 500 mg/5 mL strength), sucrose, and xanthan gum.
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Some people who are allergic to penicillin antibiotics may not be able to take Opixime, so make sure your doctor knows if you have ever had an allergic reaction to any other antibiotic.