Oflodura

Oflodura

  • Active Ingredient: Ofloxacin
  • 400 mg, 200 mg
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What is Oflodura?

The active ingredient of Oflodura brand is ofloxacin. Ofloxacin is a fluoroquinolone (flor-o-KWIN-o-lone) antibiotic that fights bacteria in the body. Ofloxacin, USP is an off-white to pale yellow crystalline powder. The molecule exists as a zwitterion at the pH conditions in the small intestine. The relative solubility characteristics of Ofloxacin, USP at room temperature, as defined by USP nomenclature, indicate that Ofloxacin, USP is considered to be soluble in aqueous solutions with pH between 2 and 5. It is sparingly to slightly soluble in aqueous solutions with pH 7 (solubility falls to 4 mg/mL) and freely soluble in aqueous solutions with pH above 9. Ofloxacin, USP has the potential to form stable coordination compounds with many metal ions. This in vitro chelation potential has the following formation order: Fe +3 > Al +3 > Cu +2 > Ni +2 > Pb +2 > Zn +2 > Mg +2 > Ca +2 > Ba +2.

Used for

Oflodura is used to treat diseases such as: Anthrax, Anthrax Prophylaxis, Bladder Infection, Bone infection, Bronchitis, Campylobacter Gastroenteritis, Cervicitis, Chancroid, Chlamydia Infection, Epididymitis, Non-Specific, Epididymitis, Sexually Transmitted, Gonococcal Infection, Disseminated, Gonococcal Infection, Uncomplicated, Joint Infection, Kidney Infections, Methicillin-Resistant Staphylococcus Aureus Infection, Mycobacterium avium-intracellulare, Treatment, Nongonococcal Urethritis, Pelvic Inflammatory Disease, Plague, Pneumonia, Prostatitis, Salmonella Enteric Fever, Salmonella Gastroenteritis, Shigellosis, Skin or Soft Tissue Infection, Traveler's Diarrhea, Tuberculosis, Active, Urinary Tract Infection.

Side Effect

Possible side effects of Oflodura include: shuffling walk; cool, pale skin; cloudy urine; fever; dry mouth; actions that are out of control; dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position; high fever.

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INDICATIONS

Oflodura ophthalmic solution is indicated for the treatment of infections caused by susceptible strains of the following bacteria in the conditions listed below:

Oflodura Ophthalmic Interactions

Avoid wearing contact lenses until you no longer have symptoms of the eye infection.

This medicine may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Do not use other eye medications unless your doctor tells you to.

It is not likely that other drugs you take orally or inject will have an effect on Oflodura used in the eyes. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

What Other Drugs Interact with Oflodura?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Oflodura has no known severe interactions with other drugs.

Oflodura has serious interactions with at least 42 different drugs.

Oflodura has moderate interactions with at least 162 different drugs.

Oflodura has mild interactions with at least 94 different drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

Oflodura side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Oflodura can cause serious side effects, including tendon problems, side effects on your nerves (which may cause permanent nerve damage), serious mood or behavior changes (after just one dose), or low blood sugar (which can lead to coma).

Stop taking this medicine and call your doctor at once if you have:

low blood sugar--headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, or feeling anxious or shaky;

nerve symptoms in your hands, arms, legs, or feet--numbness, weakness, tingling, burning pain;

serious mood or behavior changes--nervousness, confusion, agitation, paranoia, hallucinations, memory problems, trouble concentrating, thoughts of suicide; or

signs of tendon rupture--sudden pain, swelling, bruising, tenderness, stiffness, movement problems, or a snapping or popping sound in any of your joints (rest the joint until you receive medical care or instructions).

In rare cases, Oflodura may cause damage to your aorta, the main blood artery of the body. This could lead to dangerous bleeding or death. Get emergency medical help if you have severe and constant pain in your chest, stomach, or back.

Also, stop using Oflodura and call your doctor at once if you have:

severe stomach pain, diarrhea that is watery or bloody;

fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);

the first sign of any skin rash, no matter how mild;

muscle weakness, breathing problems;

little or no urination;

a seizure (convulsions);

increased pressure inside the skull--severe headaches, ringing in your ears, vision problems, pain behind your eyes; or

liver problems--upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Is Oflodura safe to take while pregnant or breastfeeding?

Oflodura should be avoided during pregnancy because it is secreted in breast milk and can cause adverse events in the infant.

Oflodura should be avoided in nursing mothers, as safe use has not been established.

DESCRIPTION

Oflodura Ophthalmic Solution USP, 0.3% is a sterile ophthalmic solution. It is a fluorinated carboxyquinolone anti-infective for topical ophthalmic use.

Chemical Name: (±)-9-Fluoro-2, 3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido -1,4 benzoxazine-6-car boxy lie acid.

Contains: Active: Oflodura 0.3% (3 mg/mL);

Preservative: benzalkonium chloride (0.005%);

Inactives: sodium chloride and water for injection. May also contain hydrochloric acid and/or sodium hydroxide to adjust pH.

Oflodura Ophthalmic Solution USP, 0.3% is unbuffered and formulated with a pH of 6.4 (range - 6.0 to 6.8). It has an osmolality of 300 mOsm/kg. Oflodura is a fluorinated 4-quinolone which differs from other fluorinated 4-quinolones in that there is a six member (pyridobenzoxazine) ring from positions 1 to 8 of the basic ring structure.

C18H20FN3O4 . Mol wt. 361.37

Before using Oflodura eye drops

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start using Oflodura eye drops it is important that your doctor knows:

  • If you are pregnant or breast-feeding.
  • If you have ever had an allergic reaction to an antibiotic, or to any eye drops.
  • If you have a heart condition or an unusual heart rhythm.
  • If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.

What Is Oflodura (Floxin)?

Oflodura is an antibiotic drug used to treat bacterial infections.

It's commonly used as an eye drop to treat conjunctivitis (pink eye) and corneal ulcers.

The tablet form of Oflodura is prescribed for various bacterial infections, such as pneumonia, bronchitis, urinary tract infections (UTI), gastrointestinal infections, prostate infections caused by E. coli, skin infections, and some sexually transmitted diseases.

It may also be used to prevent or treat anthrax or plague in certain people.

The medicine also comes as an ear drop to treat middle and outer ear infections.

Oflodura belongs to a class of drugs called fluoroquinolone antibiotics. It works by killing harmful bacteria that cause infection.

The U.S. Food and Drug Administration (FDA) approved Oflodura in 1990. It's sold under different brand names and manufactured by various companies.

WHAT IS Oflodura?

Oflodura is in a group of antibiotics called fluoroquinolones, and works by fighting bacteria in the body.

This medicine is used to treat bacterial infections that cause bronchitis, pneumonia, chlamydia, gonorrhea, skin infections, urinary tract infections, and infections of the prostate.

Additionally, the ophthalmic solution is used to treat bacterial infections of the eye, such as conjunctivitis and corneal ulcers.

Oflodura is sold under the brand names Floxin® and Ocuflox® in both the U.S. and Canada.

How should this medicine be used?

Ophthalmic Oflodura comes as an solution (liquid) to instill in the eye. It is usually instilled in the affected eye(s) four or more times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use Oflodura exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

Oflodura Interactions

Tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking, especially those listed in the Oflodura Warnings section above, and any of the following:

  • Other antibiotics
  • Antacids containing aluminum, calcium, or magnesium (includes Maalox, Mylanta, Tums, and others)
  • Anticoagulants (blood thinners) such as Coumadin or Jantoven (warfarin)
  • Certain antidepressants
  • Antipsychotics (drugs to treat mental illness)
  • Tagamet (Cimetidine)
  • Gengraf, Neoral, or Sandimmune (cyclosporine)
  • Videx (didanosine)
  • Diuretics (water pills)
  • Insulin and oral medications for diabetes
  • Certain drugs for irregular heartbeat, such as quinidine, Cordarone (amiodarone), Procanbid (procainamide), or Betapace, Betapace AF, or Sorine (sotalol)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as Advil or Motrin (ibuprofen) or Aleve (naproxen)
  • Probalan (probenecid) or Col-Probenecid (colchicine and probenecid)
  • Carafate (sucralfate)
  • Supplements or multivitamins containing iron or zinc
  • Elixophyllin, Theo-24, or Uniphyl (theophylline)

Additional studies in rats with doses up to 360 mg/kg/day during late gestation showed no adverse effect on late fetal development, labor, delivery, lactation, neonatal viability, or growth of the newborn. There are, however, no adequate and well-controlled studies in pregnant women. Oflodura ophthalmic solution should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.


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