Oflodex

Oflodex

  • Active Ingredient: Ofloxacin
  • 400 mg, 200 mg
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What is Oflodex?

The active ingredient of Oflodex brand is ofloxacin. Ofloxacin is a fluoroquinolone (flor-o-KWIN-o-lone) antibiotic that fights bacteria in the body. Ofloxacin, USP is an off-white to pale yellow crystalline powder. The molecule exists as a zwitterion at the pH conditions in the small intestine. The relative solubility characteristics of Ofloxacin, USP at room temperature, as defined by USP nomenclature, indicate that Ofloxacin, USP is considered to be soluble in aqueous solutions with pH between 2 and 5. It is sparingly to slightly soluble in aqueous solutions with pH 7 (solubility falls to 4 mg/mL) and freely soluble in aqueous solutions with pH above 9. Ofloxacin, USP has the potential to form stable coordination compounds with many metal ions. This in vitro chelation potential has the following formation order: Fe +3 > Al +3 > Cu +2 > Ni +2 > Pb +2 > Zn +2 > Mg +2 > Ca +2 > Ba +2.

Used for

Oflodex is used to treat diseases such as: Anthrax, Anthrax Prophylaxis, Bladder Infection, Bone infection, Bronchitis, Campylobacter Gastroenteritis, Cervicitis, Chancroid, Chlamydia Infection, Epididymitis, Non-Specific, Epididymitis, Sexually Transmitted, Gonococcal Infection, Disseminated, Gonococcal Infection, Uncomplicated, Joint Infection, Kidney Infections, Methicillin-Resistant Staphylococcus Aureus Infection, Mycobacterium avium-intracellulare, Treatment, Nongonococcal Urethritis, Pelvic Inflammatory Disease, Plague, Pneumonia, Prostatitis, Salmonella Enteric Fever, Salmonella Gastroenteritis, Shigellosis, Skin or Soft Tissue Infection, Traveler's Diarrhea, Tuberculosis, Active, Urinary Tract Infection.

Side Effect

Possible side effects of Oflodex include: excess air or gas in the stomach or intestines; body aches or pain; full feeling; unusual bleeding or bruising; slow or fast heartbeat; continuing ringing or buzzing or other unexplained noise in the ears; increased urination.

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Microbiology

Oflodex has in vitro activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Oflodex is bactericidal at concentrations equal to or slightly greater than inhibitory concentrations. Oflodex is thought to exert a bactericidal effect on susceptible bacterial cells by inhibiting DMA gyrase, an essential bacterial enzyme which is a critical catalyst in the duplication, transcription, and repair of bacterial DMA.

Cross-resistance has been observed between Oflodex and other fluoroquinolones. There is generally no cross-resistance between Oflodex and other classes of antibacterial agents such as beta-lactams or aminoglycosides. Oflodex has been shown to be active against most strains of the following organisms both in vitro and clinically, in conjunctival and/or corneal ulcer infections as described in the INDICATIONS section.

The safety and effectiveness of Oflodex ophthalmic solution in treating ophthalmologic infections due to the following organisms have not been established in adequate and well-controlled clinical trials. Oflodex ophthalmic solution has been shown to be active in vitro against most strains of these organisms but the clinical significance in ophthalmologic infections is unknown.

Interactions

Drug-drug. Amiodarone, bepridil, disopyramide, erythromycin, pentamidine, phenothiazines, pimozide, procainamide, quinidine, sotalol, tricyclic antidepressants: increased risk of serious adverse cardiovascular reactions

Antacids, bismuth subsalicylate, iron or zinc salts, sucralfate: decreased Oflodex absorption

Corticosteroids: increased risk of tendon rupture

Probenecid: decreased renal elimination of Oflodex

Theophylline: increased theophylline blood level and possible toxicity

Warfarin: increased warfarin effects

Drug-diagnostic tests. Alanine aminotransferase, aspartate aminotransferase, platelets: increased levels

Hemoglobin, hematocrit: decreased values

Drug-food. Milk or yogurt (consumed alone), tube feedings: impaired drug absorption

Drug-herbs. Fennel: decreased drug absorption

Dong quai, St. John's wort: phototoxicity

Drug-behaviors. Sun exposure: phototoxicity

How to use Oflodex Drops

To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.

Do not wear contact lenses while you are using this medicine. Sterilize contact lenses according to manufacturer's directions and check with your doctor before using them.

Tilt your head back, look upward and pull down the lower eyelid to make a pouch. Hold the dropper directly over the eye and place one drop into the eye. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure. This will prevent the medication from draining out. Try not to blink and do not rub your eye. Repeat these steps for your other eye if so directed, and if your dose is for more than 1 drop.

Do not rinse the dropper. Replace the dropper cap after each use.

If you are using another kind of eye medication (e.g., drops or ointments), wait at least 5 minutes before applying other medications. Use eye drops before eye ointments to allow the eye drops to enter the eye.

Use this medication regularly in order to get the most benefit from it. Continue using it for the full time prescribed even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a relapse of the infection.

Inform your doctor if your condition persists or worsens.

About where to order Chloricol for treat Plague

What Is Oflodex (Floxin)?

Oflodex is an antibiotic drug used to treat bacterial infections.

It's commonly used as an eye drop to treat conjunctivitis (pink eye) and corneal ulcers.

The tablet form of Oflodex is prescribed for various bacterial infections, such as pneumonia, bronchitis, urinary tract infections (UTI), gastrointestinal infections, prostate infections caused by E. coli, skin infections, and some sexually transmitted diseases.

It may also be used to prevent or treat anthrax or plague in certain people.

The medicine also comes as an ear drop to treat middle and outer ear infections.

Oflodex belongs to a class of drugs called fluoroquinolone antibiotics. It works by killing harmful bacteria that cause infection.

The U.S. Food and Drug Administration (FDA) approved Oflodex in 1990. It's sold under different brand names and manufactured by various companies.

Generic Name: Oflodex (Ophthalmic) (oh FLOKS a sin)Brand Name: Ocuflox

Medically reviewed by Drugs.com. Last updated on Jul 22, 2019.

Oflodex Ophthalmic Dosage

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Do not use this medicine while wearing contact lenses. Oflodex ophthalmic may contain a preservative that can discolor soft contact lenses. Wait at least 15 minutes after using this medicine before putting in your contact lenses.

Wash your hands before using the eye drops.

To apply the eye drops:

  • Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the tip down. Look up and away from the dropper and squeeze out a drop.
  • Close your eyes for 2 or 3 minutes with your head tipped down, without blinking or squinting. Gently press your finger to the inside corner of the eye for about 1 minute, to keep the liquid from draining into your tear duct.
  • Use only the number of drops your doctor has prescribed. If you use more than one drop, wait about 5 minutes between drops.
  • Wait at least 10 minutes before using any other eye drops your doctor has prescribed.

When treating a corneal ulcer, you may need to wake from sleep every 4 to 6 hours to use the medication. Follow your doctor's dosing instructions very carefully. You may notice a whitish buildup on the ulcer. This is a sign that the medication is working and is not a harmful effect. This buildup should clear within a few days or weeks of treatment.

Do not touch the tip of the eye dropper or place it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems.

Do not use the eye drops if the liquid has changed colors or has particles in it. Call your pharmacist for new medicine.

Store at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use.

An overdose of Oflodex ophthalmic is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

Copyright 1996-2019 Cerner Multum, Inc.

Latest Update: 11/9/2018, Version: 6.01

Additional studies in rats with doses up to 360 mg/kg/day during late gestation showed no adverse effect on late fetal development, labor, delivery, lactation, neonatal viability, or growth of the newborn. There are, however, no adequate and well-controlled studies in pregnant women. Oflodex ophthalmic solution should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Oflodex Warnings

Oral form: Oral Oflodex contains a black-box warning because it may raise your risk of developing tendonitis (swelling of a tendon, the tissue that connects a bone to a muscle) or a tendon rupture.

This risk can happen to anyone but is greatest in people over age 60. Tell your doctor if you've ever had:

  • A kidney, heart, or lung transplant
  • Kidney disease
  • A joint or tendon condition, such as rheumatoid arthritis

Also, let your doctor know if you participate in regular physical activity, or if you take any oral or injectable steroid medicines.

Tell your doctor right away if you experience any of the following symptoms while taking Oflodex:

  • Pain, swelling, tenderness, stiffness, or difficulty moving a muscle
  • Feeling or hearing a snap or pop in the tendon area
  • Inability to move or put weight on an affected area
  • Bruising after an injury to your tendon area

The risk of tendonitis or a tendon rupture is higher both during your treatment with Oflodex, and for several months after you stop the therapy.

Oral Oflodex also contains a black-box warning because it can worsen muscle weakness, and cause severe breathing difficulties or death, in people with myasthenia gravis (a disorder of the nervous system).

Tell your doctor if you have myasthenia gravis before taking oral Oflodex.

Also, let your doctor know if you have, or have ever had:

  • Prolonged QT interval (a condition that can cause irregular heartbeat, fainting, or sudden death)
  • An irregular or slow heartbeat
  • Chest pain
  • Nerve problems
  • Seizures
  • Low levels of potassium in your blood
  • Liver disease
  • Cerebral arteriosclerosis (narrowing of blood vessels in or near the brain)
  • Allergies to medications (especially other antibiotics)

Oral Oflodex can cause nerve damage that may not go away after you stop taking the medicine. Call your doctor immediately if you notice any of the following symptoms:

  • Numbness
  • Tingling pain
  • Burning in the arms or legs
  • Change in your ability to feel pain, cold, heat, or a light touch

This medicine shouldn't be given to children under 18.

Ear drops: If you're using Oflodex ear drops, you should avoid getting your infected ears wet while bathing. Also, don't swim while taking the medicine unless your doctor has told you otherwise.

All forms: Let your doctor know if your symptoms don't improve, or worsen, while taking this medicine.

Take Oflodex for the full duration of the period of time your doctor recommends, even if you start to feel well. Don't stop taking the medicine without first talking to your doctor.

Tell your healthcare provider you're taking Oflodex before having any type of surgery, including a dental procedure.

What are some things I need to know or do while I take Oflodex?

  • Tell all of your health care providers that you take Oflodex (ophthalmic). This includes your doctors, nurses, pharmacists, and dentists.
  • Use care when driving or doing other tasks that call for clear eyesight.
  • Bright lights may bother you. Wear sunglasses.
  • Do not use longer than you have been told. A second infection may happen.
  • Very bad and sometimes deadly allergic reactions have rarely happened with other forms of Oflodex (ophthalmic) as well as drugs like this one. Talk with the doctor.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Oflodex (ophthalmic) while you are pregnant.

Michael Stewart, Reviewed by Sid Dajani | Last edited 18 May 2017 | Certified by The Information Standard

Oflodex drops are used to treat bacterial eye infections.

Your vision may become slightly blurred for a short while after using the drops. If so, do not drive or use tools or machines until you can see clearly again.

After your symptoms have gone, continue to use the drops for a further 48 hours to make sure all the infection has cleared.

Administration

• Don't give zinc- or iron-containing drugs within 2 hours of Oflodex.

Can Oflodex eye drops cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with Oflodex eye drops. You will find a full list in the manufacturer's information leaflet supplied with the drops. Speak with your doctor if any of the following continue or become troublesome.

Oflodex Overdose

Symptoms of an Oflodex overdose may include:

  • Dizziness
  • Drowsiness
  • Nausea
  • Hot and cold flashes
  • Slurred speech
  • Confusion
  • Numbness or swelling of the face

If you suspect an overdose, contact a poison control center or emergency room immediately.

You can get in touch with a poison control center at 800-222-1222.

Before taking this medicine

You should not use this medicine if you are allergic to Oflodex or other fluoroquinolones (ciprOflodex, gemifloxacin, levOflodex, moxifloxacin, norfloxacin, and others).

Oflodex may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. This can happen during treatment or up to several months after you stop taking Oflodex. Tendon problems may be more likely in certain people (children and older adults, or people who use steroid medicine or have had an organ transplant).

Tell your doctor if you have ever had:

tendon problems, bone problems, arthritis, or other joint problems;

blood circulation problems, aneurysm, narrowing or hardening of the arteries;

a genetic disease such as Marfan syndrome or Ehler's-Danlos syndrome;

a muscle or nerve disorder, such as myasthenia gravis;

liver or kidney disease;

long QT syndrome (in you or a family member); or

low levels of potassium in your blood (hypokalemia).

Oflodex is not approved for use by anyone younger than 18 years old.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

You should not breast-feed while using this medicine.

Important Information

Oflodex can cause serious side effects, including tendon problems, nerve damage, serious mood or behavior changes, or low blood sugar.

Stop using Oflodex and call your doctor at once if you have symptoms such as: headache, hunger, irritability, numbness, tingling, burning pain, confusion, agitation, paranoia, problems with memory or concentration, thoughts of suicide, or sudden pain or movement problems in any of your joints.

In rare cases, Oflodex may cause damage to your aorta, which could lead to dangerous bleeding or death. Get emergency medical help if you have severe and constant pain in your chest, stomach, or back.

PATIENT INFORMATION

Avoid contaminating the applicator tip with material from the eye, fingers or other source.

Systemic quinolones, including Oflodex, have been associated with hypersensitivity reactions, even following a single dose. Discontinue use immediately and contact your physician at the first sign of a rash or allergic reaction.

Serious Side Effects of Oflodex

Oral form: Tell your doctor right away if you experience any of the symptoms listed in the Oflodex Warnings section above, or any of the following serious side effects:

  • Severe diarrhea
  • Confusion or hallucinations
  • Nightmares or difficulty sleeping
  • Depression, anxiety, or suicidal thoughts
  • Uncontrollable shaking of a part of the body
  • Restlessness
  • Vision changes
  • Fever
  • Skin peeling or blistering
  • Signs of an allergic reaction (may include hives, rash, itching, chest tightness, or swelling of the face, lips, tongue, throat, feet, ankles, or lower legs)
  • Hoarseness
  • Fast heartbeat
  • Fainting
  • Loss of consciousness
  • Dark-colored urine, or a decrease in the amount of urine produced
  • Yellowing of the skin or eyes (jaundice)
  • Seizures
  • Unusual bleeding or bruising
  • Joint or muscle pain

Ear drops: Tell your doctor right away if you experience any of the following serious side effects:

  • Signs of an allergic reaction (may include hives, rash, itching, chest tightness, or swelling of the face, lips, tongue, throat, feet, ankles, or lower legs)

Eye drops: Tell your doctor right away if you experience any of the following serious side effects:

  • Signs of an infection, which may include fever, chills, or sore throat
  • Severe itching
  • Loss of consciousness
  • Severe sensitivity to light
  • Signs of an allergic reaction (may include hives, rash, itching, chest tightness, or swelling of the face, lips, tongue, or throat)


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