Oflocollyre

Oflocollyre

  • Active Ingredient: Ofloxacin
  • 400 mg, 200 mg
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What is Oflocollyre?

The active ingredient of Oflocollyre brand is ofloxacin. Ofloxacin is a fluoroquinolone (flor-o-KWIN-o-lone) antibiotic that fights bacteria in the body. Ofloxacin, USP is an off-white to pale yellow crystalline powder. The molecule exists as a zwitterion at the pH conditions in the small intestine. The relative solubility characteristics of Ofloxacin, USP at room temperature, as defined by USP nomenclature, indicate that Ofloxacin, USP is considered to be soluble in aqueous solutions with pH between 2 and 5. It is sparingly to slightly soluble in aqueous solutions with pH 7 (solubility falls to 4 mg/mL) and freely soluble in aqueous solutions with pH above 9. Ofloxacin, USP has the potential to form stable coordination compounds with many metal ions. This in vitro chelation potential has the following formation order: Fe +3 > Al +3 > Cu +2 > Ni +2 > Pb +2 > Zn +2 > Mg +2 > Ca +2 > Ba +2.

Used for

Oflocollyre is used to treat diseases such as: Anthrax, Anthrax Prophylaxis, Bladder Infection, Bone infection, Bronchitis, Campylobacter Gastroenteritis, Cervicitis, Chancroid, Chlamydia Infection, Epididymitis, Non-Specific, Epididymitis, Sexually Transmitted, Gonococcal Infection, Disseminated, Gonococcal Infection, Uncomplicated, Joint Infection, Kidney Infections, Methicillin-Resistant Staphylococcus Aureus Infection, Mycobacterium avium-intracellulare, Treatment, Nongonococcal Urethritis, Pelvic Inflammatory Disease, Plague, Pneumonia, Prostatitis, Salmonella Enteric Fever, Salmonella Gastroenteritis, Shigellosis, Skin or Soft Tissue Infection, Traveler's Diarrhea, Tuberculosis, Active, Urinary Tract Infection.

Side Effect

Possible side effects of Oflocollyre include: coughing that sometimes produces a pink frothy sputum; general feeling of illness; eye pain; loss of bladder control; slow or fast heartbeat.

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INDICATIONS

Oflocollyre ophthalmic solution is indicated for the treatment of infections caused by susceptible strains of the following bacteria in the conditions listed below:

Additional studies in rats with doses up to 360 mg/kg/day during late gestation showed no adverse effect on late fetal development, labor, delivery, lactation, neonatal viability, or growth of the newborn. There are, however, no adequate and well-controlled studies in pregnant women. Oflocollyre ophthalmic solution should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

What Is Oflocollyre and How Does It Work?

Oflocollyre is a broad-spectrum fluoroquinolone antibiotic used to treat bacterial infections that cause bronchitis, pneumonia, chlamydia, gonorrhea, skin infections, urinary tract infections, and infections of the prostate.

Oflocollyre is available under the following different brand names: Floxin.

Pharmacokinetics

Serum, urine and tear concentrations of Oflocollyre were measured in 30 healthy women at various time points during a ten-day course of treatment with Oflocollyre ophthalmic solution. The mean serum Oflocollyre concentration ranged from 0.4 ng/mL to 1.9 ng/mL Maximum Oflocollyre concentration increased from 1.1 ng/mL on day one to 1.9 ng/mL on day 11 after QID dosing for 10 1/2 days. Maximum serum Oflocollyre concentrations after ten days of topical ophthalmic dosing were more than 1000 times lower than those reported after standard oral doses of Oflocollyre.

Tear Oflocollyre concentrations ranged from 5.7 to 31 µg/g during the 40 minute period following the last dose on day 11. Mean tear concentration measured four hours after topical ophthalmic dosing was 9.2 µg/g.

Corneal tissue concentrations of 4.4 µg/mL were observed four hours after beginning topical ocular application of two drops of Oflocollyre ophthalmic solution every 30 minutes. Oflocollyre was excreted in the urine primarily unmodified.

Other uses for this medicine

Oflocollyre is also sometimes used to treat other types of infection, including Legionnaires' disease (type of lung infection), certain sexually transmitted diseases, infections of the bones and joints and of the stomach and intestines. Oflocollyre may also be used to treat or prevent anthrax or plague (serious infections that may be spread on purpose as part of a bioterror attack) in people who may have been exposed to the germs that cause these infections in the air. Oflocollyre may also be used to treat or prevent travelers' diarrhea in certain patients. Talk to your doctor about the risks of using Oflocollyre to treat your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before using Oflocollyre eye drops

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start using Oflocollyre eye drops it is important that your doctor knows:

  • If you are pregnant or breast-feeding.
  • If you have ever had an allergic reaction to an antibiotic, or to any eye drops.
  • If you have a heart condition or an unusual heart rhythm.
  • If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.

How to use Oflocollyre Drops

To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.

Do not wear contact lenses while you are using this medicine. Sterilize contact lenses according to manufacturer's directions and check with your doctor before using them.

Tilt your head back, look upward and pull down the lower eyelid to make a pouch. Hold the dropper directly over the eye and place one drop into the eye. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure. This will prevent the medication from draining out. Try not to blink and do not rub your eye. Repeat these steps for your other eye if so directed, and if your dose is for more than 1 drop.

Do not rinse the dropper. Replace the dropper cap after each use.

If you are using another kind of eye medication (e.g., drops or ointments), wait at least 5 minutes before applying other medications. Use eye drops before eye ointments to allow the eye drops to enter the eye.

Use this medication regularly in order to get the most benefit from it. Continue using it for the full time prescribed even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a relapse of the infection.

Inform your doctor if your condition persists or worsens.

Short-Term Effects

  • See "What Are Side Effects Associated with Using Oflocollyre?"

Oflocollyre side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Oflocollyre can cause serious side effects, including tendon problems, side effects on your nerves (which may cause permanent nerve damage), serious mood or behavior changes (after just one dose), or low blood sugar (which can lead to coma).

Stop taking this medicine and call your doctor at once if you have:

low blood sugar--headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, or feeling anxious or shaky;

nerve symptoms in your hands, arms, legs, or feet--numbness, weakness, tingling, burning pain;

serious mood or behavior changes--nervousness, confusion, agitation, paranoia, hallucinations, memory problems, trouble concentrating, thoughts of suicide; or

signs of tendon rupture--sudden pain, swelling, bruising, tenderness, stiffness, movement problems, or a snapping or popping sound in any of your joints (rest the joint until you receive medical care or instructions).

In rare cases, Oflocollyre may cause damage to your aorta, the main blood artery of the body. This could lead to dangerous bleeding or death. Get emergency medical help if you have severe and constant pain in your chest, stomach, or back.

Also, stop using Oflocollyre and call your doctor at once if you have:

severe stomach pain, diarrhea that is watery or bloody;

fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);

the first sign of any skin rash, no matter how mild;

muscle weakness, breathing problems;

little or no urination;

a seizure (convulsions);

increased pressure inside the skull--severe headaches, ringing in your ears, vision problems, pain behind your eyes; or

liver problems--upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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