- CrCl 20-50 mL/min: Give q24hr
- CrCl Enter a drug name and Oflacin
Oflacin Ophthalmic Dosage
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Do not use this medicine while wearing contact lenses. Oflacin ophthalmic may contain a preservative that can discolor soft contact lenses. Wait at least 15 minutes after using this medicine before putting in your contact lenses.
Wash your hands before using the eye drops.
To apply the eye drops:
- Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the tip down. Look up and away from the dropper and squeeze out a drop.
- Close your eyes for 2 or 3 minutes with your head tipped down, without blinking or squinting. Gently press your finger to the inside corner of the eye for about 1 minute, to keep the liquid from draining into your tear duct.
- Use only the number of drops your doctor has prescribed. If you use more than one drop, wait about 5 minutes between drops.
- Wait at least 10 minutes before using any other eye drops your doctor has prescribed.
When treating a corneal ulcer, you may need to wake from sleep every 4 to 6 hours to use the medication. Follow your doctor's dosing instructions very carefully. You may notice a whitish buildup on the ulcer. This is a sign that the medication is working and is not a harmful effect. This buildup should clear within a few days or weeks of treatment.
Do not touch the tip of the eye dropper or place it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems.
Do not use the eye drops if the liquid has changed colors or has particles in it. Call your pharmacist for new medicine.
Store at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use.
An overdose of Oflacin ophthalmic is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.
Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
Copyright 1996-2019 Cerner Multum, Inc.
Latest Update: 11/9/2018, Version: 6.01
WHAT IS Oflacin?
Oflacin is in a group of antibiotics called fluoroquinolones, and works by fighting bacteria in the body.
This medicine is used to treat bacterial infections that cause bronchitis, pneumonia, chlamydia, gonorrhea, skin infections, urinary tract infections, and infections of the prostate.
Additionally, the ophthalmic solution is used to treat bacterial infections of the eye, such as conjunctivitis and corneal ulcers.
Oflacin is sold under the brand names Floxin® and Ocuflox® in both the U.S. and Canada.
Getting the most from your treatment
- Before you start the treatment, read the manufacturer's printed information leaflet from the pack. The manufacturer's leaflet will give you more information about the drops, and a full list of side-effects which you may experience from using them.
- If your eyes have an obvious discharge or 'crust', it can help if you bathe them with cool clean water before using Oflacin.
- Use the drops regularly, exactly as your doctor tells you to. If the infection is severe, this is likely to be every 2-4 hours for the first two days. (Just use the drops while you are awake - you do not need to wake yourself up during the night to put them in.) On day three, reduce the frequency down to four times a day.
- If your symptoms do not improve within a few days, or if they become worse, speak again with your doctor.
- When you first put the drops into your eye, it may cause blurred vision. This should quickly clear, but make sure you can see clearly again before you drive or use machines or tools.
- Take care to avoid spreading the infection from one eye to the other, and to other members of your family. Washing your hands regularly (particularly after touching your eyes), and not sharing towels or pillows will help to prevent the infection from spreading.
- If the tip of the bottle touches your eye(s) when putting the drops in, it is a good idea to squeeze out two or three drops straightaway on to some tissue and rinse the tip with salt water.
- Eye infections, or using Oflacin eye drops, may cause your eyes to become more sensitive to sunlight than usual. Wearing sunglasses may help to protect your eyes.
- If you are using any other eye drops, leave at least five minutes between applying each preparation. This is to prevent more liquid going into your eye than it can handle. Otherwise the drops will overflow from your eye and not have the intended effect.
- Even when your eye appears normal again, there may still be some bacteria present. It is important to continue to use the drops for a further 48 hours once your eye appears normal. This will help to make sure that all the bacteria have been killed. It is likely that you may need to use the drops for about a week, but you should not use them for any longer than 10 days.
- Do not wear contact lenses until your symptoms have completely gone. Wait for 24 hours after the last dose of eye drops before using your lenses again.
Pregnancy Category C: Oflacin has been shown to have an embryocidal effect in rats and in rabbits when given in doses of 810 mg/kg/day (equivalent to 9000 times the maximum recommended daily ophthalmic dose) and 160 mg/kg/day (equivalent to 1800 times the maximum recommended daily ophthalmic dose).
These dosages resulted in decreased fetal body weight and increased fetal mortality in rats and rabbits, respectively. Minor fetal skeletal variations were reported in rats receiving doses of 810 mg/kg/day. Oflacin has not been shown to be teratogenic at doses as high as 810 mg/kg/day and 160 mg/kg/day when administered to pregnant rats and rabbits, respectively.
How to use Oflacin eye drops
- Wash your hands well before you use the drops.
- Remove the cap.
- Tilt your head back a little and pull the lower l >
Oflacin Ophthalmic Solution USP, 0.3% is a sterile ophthalmic solution. It is a fluorinated carboxyquinolone anti-infective for topical ophthalmic use.
Chemical Name: (±)-9-Fluoro-2, 3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido -1,4 benzoxazine-6-car boxy lie acid.
Contains: Active: Oflacin 0.3% (3 mg/mL);
Preservative: benzalkonium chloride (0.005%);
Inactives: sodium chloride and water for injection. May also contain hydrochloric acid and/or sodium hydroxide to adjust pH.
Oflacin Ophthalmic Solution USP, 0.3% is unbuffered and formulated with a pH of 6.4 (range - 6.0 to 6.8). It has an osmolality of 300 mOsm/kg. Oflacin is a fluorinated 4-quinolone which differs from other fluorinated 4-quinolones in that there is a six member (pyridobenzoxazine) ring from positions 1 to 8 of the basic ring structure.
C18H20FN3O4 . Mol wt. 361.37