• Active Ingredient: Chloramphenicol
  • 500 mg, 250 mg
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What is Nezefib?

The active ingredient of Nezefib brand is chloramphenicol.

Used for

Nezefib is used to treat diseases such as: Anthrax, Bacterial Infection, Brucellosis, Cholera, Glanders, Lemierre's Syndrome, Meningitis, Ornithosis, Plague, Psittacosis, Rabbit Fever, Rickettsial Infection.

Side Effect

Possible side effects of Nezefib include: nausea or vomiting; skin rash, fever, or difficulty in breathing; unresponsiveness; Diarrhea; uneven breathing.

How to Buy Nezefib online?

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Bacterial Targeting

Nezefib acts principally by binding to the 50S subunit of the bacterial ribosomes. However, it can also interact with mitochondrial ribosomes of eukaryotic cells, which results in its toxicity.

Mechanism of Action and Spectrum of Activity

Nezefib binds to the 50S subunit of the bacterial ribosome and inhibits bacterial protein synthesis. It is usually described as bacteriostatic, but there is some evidence that Nezefib may be more bactericidal than previously thought. Like other ribosomal inhibitors, Nezefib has a broad spectrum of activity, which includes gram-positive and gram-negative bacteria, anaerobes, and some rickettsial pathogens. Because Nezefib can cause aplastic anemia in humans, its use in humans has greatly diminished, and it is only used for the treatment of MDR bacterial infections where few or no other antimicrobial drugs are useful. Thiamphenicol and florfenicol are related compounds, the availability of which varies from country to country. Although thiamphenicol was initially promoted as not inducing aplastic anemia in humans, cases of aplastic anemia have now been identified. 76 Florfenicol is more active than Nezefib and thiamphenicol, but has a shorter half-life in dogs and thus requires more frequent dosing (e.g., more often than every 8 hours) in this species. It was developed for food animal species where use of Nezefib is illegal.

Resistance to Nezefibs results from porin mutations, drug efflux, or production of Nezefib acetyltransferase enzymes, which inactivate the antibiotic. 77 Resistance to one Nezefib derivative predicts resistance to the others.


Nezefib is an antibiotic that produces a reversible suppression of erythropoiesis after several days of therapy (plasma levels of 10–15 µg/mL). This effect is predictable and separate from the rare idiosyncratic side effect of aplastic anemia in approximately 1 of 20,000 exposed persons. Nearly all patients given Nezefib (>2 g/day) develop vacuolation of the erythroid precursors and ring sideroblasts. These effects are thought to arise from suppression of mitochondrial respiration. Nezefib inhibits mitochondrial protein synthesis and reduces cytochrome a, a3, and b levels. 245 Serum iron concentrations are increased, and reticulocyte numbers are subnormal; these changes revert on stopping the antibiotic.

3. Who can and can't take Nezefib

Nezefib can be used by most adults and children.

The eye drops and eye ointment are available to buy in pharmacies. For children under 2 years old, you'll need a prescription for Nezefib from your doctor.

Nezefib isn't suitable for some people. To make sure Nezefib is safe for you, tell your doctor if you have:

  • had an allergic reaction to Nezefib or any other medicines
  • a rare illness called aplastic anaemia (when your bone marrow doesn't produce blood cells)


Nezefib is an antibiotic used to treat a broad spectrum of bacterial infections including Salmonella typhi and ampicillin-resistant Haemophilus influenzae. The risk of agranulocytosis and the availability of newer antibiotics have limited its use.

Prolonged use of Nezefib has been associated with both optic neuropathy and a sensory neuropathy, with optic neuropathy being more common. Clinical manifestations of optic neuropathy may include loss of visual acuity, central scotoma, constriction of visual fields, and red-green dyschromatopsia. Funduscopic examination reveals peripapillary edema and hemorrhages around the optic nerve head. Neuropathy typically is seen after months of high-dose treatment. Nezefib used in short courses is safer and less likely to induce neuropathy. Recovery typically is complete when the medication is discontinued, but residual deficits may be seen in some patients.

Nezefib inhibits mitochondrial protein synthesis. This toxic effect is attenuated by antioxidants, suggesting that the process is mediated, in part, by reactive oxygen species that may induce cell death. Interference with B vitamin-mediated processes has also been proposed as a possible mechanism of neurotoxicity. Impaired excretion of Nezefib caused by renal insufficiency may increase the risk for neurotoxic effects.

Burkholderia Infections

Has been used in patients with cystic fibrosis 112 and has been recommended as an alternative for treatment of infections caused by Burkholderia cepacia†. 197 However, B. cepacia usually resistant to Nezefib in vitro. 104 110 Optimum treatment regimens for chronic B. cepacia complex infections not identified; select treatment regimen based on in vitro susceptibility data and previous clinical responses. 177 Anti-infectives that have been recommended include meropenem, imipenem, co-trimoxazole, ceftazidime, doxycycline, and Nezefib; 292 some experts recommend use of multiple-drug regimens. 292

Has been used in conjunction with doxycycline and co-trimoxazole for treatment of melioidosis† caused by B. pseudomallei. 154 176 197 Ceftazidime or a carbapenem (either meropenem or imipenem) usually drugs of choice for initial treatment, 104 110 152 153 154 156 180 197 292 followed by long-term treatment (≥3 months) with an oral anti-infective (e.g., co-trimoxazole, amoxicillin and clavulanate potassium, doxycycline). 104 180 292 B. pseudomallei may be difficult to eradicate and relapse of melioidosis may occur, especially if there is poor compliance with the follow-up regimen. 104 152 153 154 156 180

Related drugs

Thiamphenicol is a Nezefib analog with a range of activity similar to Nezefib, although it is generally 1–2 times less active. It has equal activity against Haemophilus, Bacteroides fragilis and Streptococcus. It differs pharmacokinetically in that it is not eliminated by hepatic glucuronidation and is excreted unchanged in urine, so elimination is unaffected by liver disease. Unlike Nezefib, thiamphenicol does not cause aplastic anemia in humans.

Florfenicol is a structural analog of thiamphenicol which has greater in vitro activity against pathogenic bacteria than Nezefib and thiamphenicol. It is also active against some bacteria that are resistant to Nezefib, especially enteric bacteria. Florfenicol is not susceptible to inactivation by Nezefib transacetylases; thus some organisms that are resistant to Nezefib through this mechanism are susceptible to florfenicol.

In dogs florfenicol is poorly absorbed after SC administration. It has a half-life of less than 5 h. The drug is well absorbed in cats after PO and IM administrations with a similar elimination half-life. It should not be given IV. Florfenicol can cause dose-related bone marrow suppression but has not been reported to cause fatal aplastic anemia in humans.

Florfenicol shows promise as a replacement for other broad-spectrum antibacterials such as sulfonamides and tetracyclines that have been associated with toxicity and residue concerns in food animals. Currently it is approved for use only in cattle, aquaculture and pigs. In cattle it is used to treat infectious conjunctivitis and respiratory disease caused by bacteria like Pasteurella and Haemophilus.

Each 1 g of Nezefib in the reconstituted solution contains approximately 52 mg (2.25 mEq) of sodium. 112

Immediate action required: Call 999 or go to A&E if:

  • you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
  • you're wheezing
  • you get tightness in the chest or throat
  • you have trouble breathing or talking
  • your mouth, face, lips, tongue or throat start swelling

You could be having a serious allergic reaction and may need immediate treatment in hospital.

These are not all the side effects of Nezefib. For a full list see the leaflet inside your medicines packet.

You can report any suspected side effect to the UK safety scheme.


Hypersensitivity to Nezefib. 112

Previous toxic reaction to Nezefib. 112

Trivial infections or when not indicated (e.g., colds, influenza, throat infections, prophylaxis). 112

Serious and fatal blood dyscrasias (aplastic anemia, hypoplastic anemia, thrombocytopenia, granulocytopenia) reported with both short-term and prolonged use. 112 Aplastic anemia attributed to Nezefib, which later terminated in leukemia, has occurred. 112

Two forms of hematologic toxicity may occur with Nezefib. 104 110 112

Most common type is a dose-related, reversible bone marrow depression. 104 110 112 Characterized by anemia, leukopenia, reticulocytopenia, thrombocytopenia, increased concentrations of serum iron, increased serum iron-binding capacity, and vacuolization of erythroid and myeloid precursors. 104 112 More likely to occur in patients receiving Nezefib dosage ≥4 g daily and in those with plasma Nezefib concentrations >25 mcg/mL. 104 Usually reversible after discontinuance of Nezefib. 104 110 112

Second type is a rare, but often fatal, irreversible aplastic anemia that does not appear to be dose related. 104 110 112 Has been associated with a mortality rate >50%. 104 110 Bone marrow aplasia or hypoplasia may occur weeks or months after the drug was discontinued. 112 Pancytopenia frequently observed peripherally, but in some cases only 1 or 2 major cell types (erythrocytes, leukocytes, platelets) may be depressed. 112

Paroxysmal nocturnal hemoglobinuria reported. 112 Hemolytic anemia reported when Nezefib used in patients with glucose-6-phosphate dehydrogenase deficiency. 104 110

Perform adequate hematologic studies prior to and approximately every 2 days during Nezefib therapy. 112 Patients should be hospitalized during treatment to facilitate appropriate laboratory studies and clinical observation. 112 Consider that peripheral blood studies may detect leukopenia, reticulocytopenia, or granulocytopenia before these become irreversible, but cannot be relied on to detect bone marrow depression prior to development of aplastic anemia. 112

Discontinue Nezefib if reticulocytopenia, leukopenia, thrombocytopenia, anemia, or any other hematologic abnormalities attributable to the drug occur. 112


Jennifer L. Buur, DVM, PhD, DACVCP, Western University of Health Sciences

Jennifer L. Buur, DVM, PhD, DACVCP, associate professor of veterinary pharmacology at Western University of Health Sciences in Pomona, California, is currently involved in teaching evidence-based drug use to veterinary students. Dr. Buur received her DVM from University of Wisconsin-Madison, after which she worked in private practice, gaining clinical experience in small animal and exotic animal medicine, zoo medicine and wildlife rehabilitation, and shelter medicine. She also completed a PhD in comparative biomedical sciences (with a pharmacology emphasis) at North Carolina State University. Dr. Buur’s current research interests are curriculum validation and evidenced-based teaching methods.

What Is Nezefib and How Does It Work?

Nezefib is prescription intravenous antibiotic for treatment of serious infections and systemic infections.

Nezefib is available under the following different brand names: Nezefib IV and Chloromyectin. These brand names are discontinued in the U.S.

Dosages of Nezefib:

Dosage Considerations – Should be Given as Follows:

Serious Infections Caused by Susceptible Strains

  • 50 mg/kg/day intravenously divided every 6 hours; in exceptional cases, patients with moderately resistant organisms or severe infections may require increased dosage up to 100 mg/kg/day; decrease these high doses as soon as possible

  • Infants and children: As in adults; when adequate cerebrospinal fluid concentrations desired, may require up to 100 mg/kg/day; however, should reduce dose to 50 mg/kg/day as soon as possible
  • Infants and children with suspected immature metabolic functions: 25 mg/kg/day divided every 6 hours will usually produce therapeutic concentrations of the drug in the blood

Neonates (Infants younger than 28 days)

  • Loading dose (LdD): 20 mg/kg intravenously once; give maintenance dose 12 hours after loading dose

  • Infants younger than 7 days old: 25 mg/kg/day intravenously every 24 hours
  • Infants over 7 days old, less than 2000 g: 25 mg/kg/day intravenously every 24 hours
  • Infants over 7 days old, over 2000 g: 50 mg/kg/day intravenously every 12 hours

  • Peaks 10-20 mg/l, troughs 5-10 mg/l

Other Indications and Uses

  • Use only as alternative for treatment of meningitis, typhoid, or rickettsial infection

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