Mi-Riemser tablets


  • Active Ingredient: Minocycline
  • 50 mg
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What is Mi-Riemser?

The active ingredient of Mi-Riemser brand is minocycline. Minocycline is a tetracycline antibiotic that fights bacteria in the body. Minocycline hydrochloride capsules, USP for oral administration contain Minocycline hydrochloride, USP equivalent to 50 mg, 75 mg or 100 mg of Minocycline. The capsule also contains the following inactive ingredients: corn starch and magnesium stearate. The empty hard gelatin capsule shells contain titanium dioxide, sodium lauryl sulfate, and gelatin. In addition, the 50 mg capsule shells contain FD&C Red #3, D&C Red #33, and FD&C Yellow #6; the 75 mg capsule shells contain black iron oxide; and the 100 mg capsule shells contain FD&C Blue #1, D&C Red #28, FD&C Red #40, and red iron oxide. The capsules are printed with edible ink containing shellac, dehydrated alcohol, isopropyl alcohol, butyl alcohol, propylene glycol, strong ammonia solution, black iron oxide, and potassium hydroxide.

Used for

Mi-Riemser is used to treat diseases such as: Acne, Actinomycosis, Bacterial Infection, Bartonellosis, Brucellosis, Bullous Pemphigoid, Campylobacter Gastroenteritis, Cholera, Granuloma Inguinale, Meningitis, Meningococcal, Mycoplasma Pneumonia, Ocular Rosacea, Pemphigoid, Pemphigus, Periodontitis, Plague, Psittacosis, Q Fever, Rabbit Fever, Rheumatoid Arthritis, Rosacea, Skin and Structure Infection, Skin or Soft Tissue Infection, Trachoma.

Side Effect

Possible side effects of Mi-Riemser include: blistering, peeling, or loosening of the skin; large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs; redness of the skin; upper right abdominal or stomach pain; Continuing ringing or buzzing or other unexplained noise in the ears; loss of appetite; chest pain, possibly moving to the left arm, neck, or shoulder; hives or welts.

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What Other Drugs Interact with Mi-Riemser?

If your doctor has directed you to use this medication for your condition, your doctor or pharmacist may already be aware of any possible drug interactions or side effects and may be monitoring you for them. Do not start, stop, or change the dosage of this medicine or any medicine before getting further information from your doctor, healthcare provider or pharmacist first.

Severe Interactions of Mi-Riemser include:

Mi-Riemser has serious interactions with at least 54 different drugs.

Mi-Riemser has moderate interactions with at least 32 different drugs.

Mi-Riemser has mild interactions with at least 26 different drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

Effects of Mi-Riemser on cancer

Degradation of the extracellular matrix by MMPs is a critical phenomenon in cancer invasion and metastasis (Hua et al., 2011). Considering the potent inhibitory effects of tetracyclines against MMPs, their anti-cancer potential has been studied in a variety of cancers, including melanoma, lung, breast and prostate cancers (Lokeshwar, 2011). Mi-Riemser has been shown to inhibit in vitro invasion and experimental pulmonary metastasis in mouse renal adenocarcinoma (MRAC-PM2) cells (Masumori et al., 1994). In addition, the i.p. administration of Mi-Riemser reduced the number of metastatic nodules in the lung when MRAC-PM2 cells were i.v. injected to mice. Mi-Riemser also suppressed the type IV collagenolytic activity of these cells, which can contribute to the suppression of their metastatic potential (Masumori et al., 1994). Considering its osteotropism, Mi-Riemser was highly effective in inhibiting MMPs produced by tumour cells in the bone (Saikali and Singh, 2003). Moreover, when combined with celecoxib, Mi-Riemser inhibited the osseous metastasis of breast cancer in nude mice, by increasing tumour cell death and decreasing tumour expression of MMP-9 and VEGF (Niu et al., 2008). In addition, Mi-Riemser has recently been shown to be a promising new candidate for adjuvant therapy against malignant gliomas, as it reduced glioma growth both in vitro and in an experimental mouse model, an effect that was associated with a strongly attenuated expression of membrane type 1 MMP (MT1-MMP) in glioma-associated microglia (Markovic et al., 2011). Furthermore, Mi-Riemser has been described to inhibit tumour growth in the xenograft tumour model of C6 glioma cells. This effect was associated with an induction of autophagic cell death, although Mi-Riemser still induced cell death through the activation of caspase-3 when autophagy was inhibited (Liu et al., 2011). Therefore, these experimental data confirm that the anti-proliferative, anti-angiogenic and matrix-stimulatory activities displayed by Mi-Riemser increase its anti-metastasic and anti-tumour potential. Moreover, Mi-Riemser may benefit patients undergoing standard cancer chemotherapy by alleviating drug-induced gut damage. In a model of 5-fluorouracil-induced small intestinal mucositis, Mi-Riemser protected mice from gut injury. Body weight loss, diarrhoea and villi measurements were improved by Mi-Riemser treatment, which also repressed the expression of TNFα, IL-1β and iNOS, decreased the apoptotic index, and inhibited PARP-1 activity in the mouse small intestine. In addition, Mi-Riemser treatment appeared to enhance the anti-tumour effects of 5-fluorouracil in tumour CT-26 xenograft mice (Huang et al., 2009a).

What other drugs will affect Mi-Riemser?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may interact with Mi-Riemser, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Side Effects

Nausea, vomiting, diarrhea, lightheadedness, dizziness, or a feeling of spinning may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: painful/difficult swallowing, hearing changes (such as ringing in the ears, decreased hearing), joint stiffness/pain/swelling, signs of kidney problems (such as change in the amount of urine, pink urine), signs of liver problems (such as loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine), yellow-gray-brown tooth discoloration, blue-gray skin/tongue/lips/gums).

Mi-Riemser may rarely cause a serious increase in pressure inside the skull (intracranial hypertension-IH). The risk of this side effect is greater for women of childbearing age who are overweight or who have had IH in the past. If IH develops, it usually goes away after Mi-Riemser is stopped; however, there is a chance of permanent vision loss or blindness. Get medical help right away if you have: severe/lasting headache, vision changes (such as blurred/double vision, decreased vision, sudden blindness), nausea/vomiting that doesn't stop.

This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Tell your doctor right away if you develop: diarrhea that doesn't stop, abdominal or stomach pain/cramping, blood/mucus in your stool.

Do not use anti-diarrhea or opioid medications if you have any of these symptoms because these products may make them worse.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever that doesn't go away, new or worsening lymph node swelling, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

home drugs a-z list Minocin Capsules(Mi-Riemser) side effects drug center

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Minocin Capsules (Mi-Riemser hydrochloride) is a tetracycline antibiotic used to treat many different bacterial infections, such as urinary tract infections, severe acne, gonorrhea, tick fever, chlamydia, and others. Minocin is available in generic form. Common side effects of Minocin include:

  • nausea,
  • vomiting,
  • upset stomach,
  • diarrhea,
  • lightheadedness,
  • dizziness,
  • spinning sensation,
  • unsteadiness,
  • drowsiness,
  • tired feeling,
  • joint or muscle pain,
  • discoloration of your skin or nails,
  • skin rash or itching,
  • mouth sores,
  • swollen tongue,
  • discoloration of your gums,
  • cough,
  • increased skin sensitivity to sunlight (sunburn more easily), or
  • vaginal itching or discharge.

The usual adult dosage of Minocin Capsules is 200 mg initially followed by 100 mg every 12 hours. Dose may differ depending on the condition for which this drug is prescribed. Minocin Capsules may interact adversely with certain retinoids, digoxin, penicillins, warfarin, and live bacterial vaccines. Some antibiotics may decrease the effectiveness of hormonal birth control such as the pill, ring or patch. Ask your doctor if you should use additional reliable birth control methods while using this antibiotic. This medication is not recommended for use during pregnancy because of possible harm to a fetus. Women of child-bearing age should use effective birth control while using this medication. Consult your doctor. This medication passes into breast milk in very small amounts. Consult your doctor before breastfeeding.

Our Minocin Capsules Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Rated Mi-Riemser for Acne Report

I’m 15 years old and I have had severe acne for about 4-5 years and just last month I decided to start taking Mi-Riemser, I haven’t seen any results at all, I still get breakouts all over my face and my body including my chest and back, if I don’t see any results in the next two months I’m going back into the dermatologist and possibly experimenting with birth control

Effects of Mi-Riemser on periodontal disease

The pharmacological profile of tetracyclines, which combines anti-microbial with anti-inflammatory and anti-apoptotic properties, makes them suitable for periodontal disease treatment, which is characterized by an inflammatory process in addition to its well-known microbial aetiology (Soory, 2008). At the levels conventionally detected in the plasma and gingival crevicular fluid, Mi-Riemser causes a significant stimulation of osteoblastic cells, whereas long-term exposure of these cells to tetracyclines results in a proportional increase in the mineralized bone matrix (Gomes and Fernandes, 2007). These effects are achieved without affecting the survival and protein expression of human gingival fibroblasts, epithelial cells and periodontal ligament fibroblasts (Suzuki et al., 2006). Taken together with their anti-microbial activity, these effects may explain the efficacy, in particular of Mi-Riemser, in reducing disease progression and promoting periodontal healing when administered at doses of 100–200 mg·day −1 for 7–14 days (Kirkwood et al., 2007; Basegmez et al., 2011).


See also Side Effects section.

Before taking Mi-Riemser, tell your doctor or pharmacist if you are allergic to it; or to other tetracyclines (such as doxycycline); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, liver problems, trouble swallowing, esophagus problems (such as hiatal hernia or reflux/heartburn).

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

Mi-Riemser may cause live bacterial vaccines (such as typhoid vaccine) to not work as well. Do not have any immunizations/vaccinations while using this medication unless your doctor tells you to.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Children younger than 8 years may be more sensitive to the side effects of Mi-Riemser, especially tooth discoloration. Tooth discoloration has also occurred in older children and in young adults. Discuss the risks and benefits of this medication with the doctor.

Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using Mi-Riemser. Mi-Riemser may harm an unborn baby. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.

This medication passes into breast milk. Consult your doctor before breast-feeding.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Mi-Riemser only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2019 Cerner Multum, Inc. Version: 15.01.

Rated Mi-Riemser for Skin and Structure Infection Report

DO NOT TAKE. Gave me akathisia and suicidal ideation. Never felt worse in my life. Please consider other options and do your research on all drugs before taking.

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