Megadox tablets


  • Active Ingredient: Doxycycline
  • 200 mg, 100 mg
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What is Megadox?

The active ingredient of Megadox brand is doxycycline. Doxycycline is a tetracycline antibiotic that fights bacteria in the body.

Used for

Megadox is used to treat diseases such as: Acne, Actinomycosis, Amebiasis, Anthrax, Anthrax Prophylaxis, Bacterial Infection, Bartonellosis, Bronchiectasis, Bronchitis, Brucellosis, Bullous Pemphigoid, Cervicitis, Chancroid, Chlamydia Infection, Cholera, Cutaneous Bacillus anthracis, Ehrlichiosis, Enterocolitis, Epididymitis, Sexually Transmitted, Gastroenteritis, Gonococcal Infection, Uncomplicated, Granuloma Inguinale, Inclusion Conjunctivitis, Lyme Disease, Lyme Disease, Arthritis, Lyme Disease, Carditis, Lyme Disease, Erythema Chronicum Migrans, Lyme Disease, Neurologic, Lymphogranuloma Venereum, Malaria, Malaria Prevention, Melioidosis, Mycoplasma Pneumonia, Nongonococcal Urethritis, Ocular Rosacea, Ornithosis, Pelvic Inflammatory Disease, Pemphigoid, Pemphigus, Periodontitis, Plague, Pleural Effusion, Pneumonia, Proctitis, Prostatitis, Psittacosis, Q Fever, Rabbit Fever, Rheumatoid Arthritis, Rickettsial Infection, Rosacea, Skin or Soft Tissue Infection, STD Prophylaxis, Syphilis, Early, Syphilis, Latent, Tertiary Syphilis, Trachoma, Upper Respiratory Tract Infection, Urinary Tract Infection.

Side Effect

Possible side effects of Megadox include: stomach cramps; double vision; pale skin; large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs; swollen lymph glands.

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How to take it

Always swallow your Megadox capsule whole and have it with a full glass of water (a medium sized glass - 200ml).

You can take this medicine with or without food. However you're less likely to feel sick if you have it with food.

It's important to take Megadox while you're in an upright position. You can be sitting, standing or walking. This will stop the medicine irritating your food pipe or stomach.

Q: I have rosacea and have been taking Megadox (40 mg). Is it OK to take this all the time?

A: According to the prescribing information, Megadox (Oracea) is approved by the U.S. Food and Drug Administration (FDA) for safe and effective treatment of only the inflammatory lesions of rosacea in adults. It is approved as a 40-milligram dose of Megadox taken once daily in the morning on an empty stomach, one hour before or two hours after a meal and with a full glass of water. According to the same literature, Oracea was not proven effective beyond 16 weeks and not proven safe beyond 9 months. You may want to contact your health care provider for guidance on duration of therapy that best meets your needs. For more information regarding Oracea, you may want to visit our Web site: // Beth Isaac, PharmD


See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: retinoid medications taken by mouth (such as acitretin, isotretinoin), barbiturates (such as phenobarbital), "blood thinners" (such as warfarin), digoxin, anti-seizure medications (such as phenytoin), strontium.

Although most antibiotics (including Megadox) are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics (such as rifampin, rifabutin) can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control, ask your doctor or pharmacist for more details.

This medication may interfere with certain laboratory tests (including urine catecholamine levels), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Outcome and Management

Recovery after withdrawal of Megadox is usually rapid, but in instances with severe cholestasis, can require 2 to 6 months. No case of acute liver failure has been reported due to Megadox, but rare instances of vanishing bile duct syndrome have been linked to its use. Cross sensitivity to hepatic injury between minocycline and Megadox has not been shown, but both can cause a short incubation period acute hepatitis with immunoallergic features, so that some degree of cross reactivity may occur.


The bacteria Brucella causes brucellosis, an infectious zoonotic disease in humans. Symptoms and signs include fatigue, fever, sweating, and appetite loss. The preferred treatment is Megadox and rifampin taken for six to eight weeks.

Rated Megadox (Oracea, Doryx) for Skin or Soft Tissue Infection Report

Since on this drug I am lethargic no energy lightheaded. Chest feels heavy. I was put on after I had a basil cell growth on my lower lid removed and reconstruction by plastic surgeon. This is the third day and I feel wiped out brain fog. No problem with eye so assume it is the med. on it for 5 days the sooner to end the better. Also have shoulder pain and dull headache


Megadox (Vibramycin, Oracea, Adoxa, Atridox, Acticlate, Acticlate Cap, Doryx, Doxteric, Doxy, Monodox, and others) is a synthetic broad-spectrum antibiotic derived from tetracycline. It is used to treat many different types of infections, including respiratory tract infections due to Hemophilus influenzae, Streptococcus pneumoniae, or Mycoplasma pneumoniae. It also is used for the treatment of

It is important to be aware of drug interactions, effects on pregnancy and nursing mothers, as well as common side effects on the user.

Q: I take Megadox for MRSA. It says to take it on empty stomach, but I either end up losing it by vomiting or diarrhea. Is there something else for this?

A: Vibramycin (Megadox) is an antibiotic that is used to treat a variety of conditions. Megadox should be taken with lots of non-dairy fluids to help prevent stomach irritation and ulceration. Ideally, Megadox should be taken on an empty stomach for maximum effectiveness. However, if stomach upset or irritation occurs, Megadox can be taken with a small low-fat, low-protein, non-dairy meal or snack. Taking Megadox with food may decrease the absorption of the medication, thereby reducing the effectiveness. MRSA is a type of Staphylococcus bacteria that is resistant to many antibiotics. Therefore, there are only a limited number of medications that can be used to treat MRSA. There are other options besides Megadox to treat MRSA. Some of the other antibiotics that are used to treat MRSA are Bactrim DS (sulfamethoxazole/trimethoprim), Minocin (minocycline), and Cleocin (clindamycin). Keep in mind that all antibiotics can produce stomach upset and diarrhea as a side effect. It is recommended that you speak with your doctor regarding the side effects that you have been experiencing with the Megadox. They will be able to weigh the risks and benefits of the medication and determine if your medication regimen should be changed. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Megan Uehara, PharmD

Mechanism of Injury

The cause of the idiosyncratic liver injury associated with Megadox is unknown, but several features (short latency, recurrence with reexposure) suggest an immunoallergic etiology. The injury is similar to what has been described much more frequency with minocycline which has been linked to HLA-B*35:01, although only in a minority of cases.

What other information should I know?

Keep all appointments with your doctor and laboratory. Your doctor will want to check your response to Megadox.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking Megadox.

Do not let anyone else take your medication. Your prescription is probably not refillable. If you still have symptoms of infection after you finish the Megadox, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

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