Medimacrol tablets

Medimacrol

  • Active Ingredient: Azithromycin
  • 500 mg, 250 mg, 100 mg
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What is Medimacrol?

The active ingredient of Medimacrol brand is azithromycin. Azithromycin is an antibiotic that fights bacteria.

Used for

Medimacrol is used to treat diseases such as: Babesiosis, Bacterial Endocarditis Prevention, Bacterial Infection, Bartonellosis, Bronchitis, Cervicitis, Chancroid, Chlamydia Infection, COPD, Acute, Cystic Fibrosis, Gonococcal Infection, Uncomplicated, Granuloma Inguinale, Legionella Pneumonia, Lyme Disease, Erythema Chronicum Migrans, Mycobacterium avium-intracellulare, Prophylaxis, Mycobacterium avium-intracellulare, Treatment, Mycoplasma Pneumonia, Nongonococcal Urethritis, Otitis Media, Pelvic Inflammatory Disease, Pertussis, Pertussis Prophylaxis, Pharyngitis, Pneumonia, Sinusitis, Skin and Structure Infection, Skin or Soft Tissue Infection, STD Prophylaxis, Tonsillitis/Pharyngitis, Toxoplasmosis, Typhoid Fever, Upper Respiratory Tract Infection.

Side Effect

Possible side effects of Medimacrol include: body aches or pain; itching of the vagina or genital area; headache; muscle aches and pains; redness or other discoloration of the skin; sores, ulcers, or white spots on the lips or in the mouth; swelling of the face, ankles, hands, feet, or lower legs.

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Q: Can a bariatric patient take a Z-pack?

A: After bariatric or weight-loss surgery, patients may no longer be able to take whole pills or tablets. So, these patients often need medications that come in formulations that are chewable, liquid, or are able to be crushed. Bariatric patients will not be able to take extended-release formulations or medications that are enteric-coated. Medimacrol is an antibiotic that helps the body fight bacteria. It is used to treat bacterial infections, including respiratory infections, ear infections, sinus infections, certain sexually transmitted diseases (STDs), skin infections, pelvic inflammatory disease (PID), and Strep throat. Medimacrol comes in a dose pack called a Z-pack that consists of film-coated tablets that are packaged for a 5 day course of treatment. Film-coating is often used to help ease swallowing, to mask a bad taste or an odor, and to help stabilize a drug. Crushing a film-coated tablet can alter these factors. Medimacrol is also available as a liquid suspension that may be more appropriate for use in a bariatric patient. Consult your doctor for specific recommendations based on your circumstances. Be sure to follow your doctor's instructions and always finish the complete course of antibiotic treatment even if your symptoms improve. Sarah Lewis, PharmD

9. Common questions

Medimacrol is from a group of medicines called macrolide antibiotics. Macrolide antibiotics work by killing the bacteria that cause the infection.

There are other macrolide antibiotics that work in the same way as Medimacrol. They include erythromycin and clarithromycin.

It's usual to take Medimacrol once a day. For erythromycin, it's usually 4 times a day, and twice a day for clarithromycin.

Erythromycin is more likely to cause diarrhoea than either Medimacrol or clarithromycin.

All macrolides can be used to treat chest and skin infections. Medimacrol and erythromycin can also be used to treat sexually transmitted infections.

Clarithromycin can also be used to treat Helicobacter pylori, bacteria that can cause stomach ulcers.

Medimacrol and other macrolide antibiotics kill similar types of bacteria to penicillin antibiotics, such as amoxicillin.

Some people are allergic to penicillin antibiotics - they can take macrolides like Medimacrol instead.

For most infections, you should feel better within a few days.

It's very important that you keep taking Medimacrol until your course is finished.

Do this even if you feel better. It'll help stop the infection coming back.

Tell your doctor if you don't start feeling better after taking Medimacrol for 3 days. Also tell them if, at any time, you start to feel worse.

Yes, you can drink alcohol with Medimacrol.

Some people get a fungal infection called thrush after taking a course of antibiotics like Medimacrol. Antibiotics kill the normal harmless bacteria that help to protect you against thrush.

Symptoms of thrush in the mouth include redness and itching. Women may get vaginal itching.

Ask your doctor or pharmacist for advice if this happens to you.

Medimacrol doesn't stop contraceptive pills, including the combined pill and emergency contraception.

But if Medimacrol makes you vomit or have severe diarrhoea (6 to 8 watery poos in 24 hours) for more than 24 hours, your contraceptive pills may not protect you from pregnancy. Look on the pill packet to find out what to do.

There's no firm evidence to suggest that taking Medimacrol will reduce fertility in either men or women.

However speak to a pharmacist or your doctor before taking it if you're trying to get pregnant.

You can eat and drink normally while taking Medimacrol.

Medimacrol can cause dizziness. If you're affected by it, do not drive, ride a bike or operate machinery.

Susceptibility Testing for MAC

The disk diffusion techniques and dilution methods for susceptibility testing against gram-positive and gram-negative bacteria should not be used for determining Medimacrol MIC values against mycobacteria. In vitro susceptibility testing methods and diagnostic products currently available for determining MIC values against MAC organisms have not been standardized or validated. Medimacrol MIC values will vary depending on the susceptibility testing method employed, composition and pH of media, and the utilization of nutritional supplements. Breakpoints to determine whether clinical isolates of M. avium or M. intracellulare are susceptible or resistant to Medimacrol have not been established.

The clinical relevance of Medimacrol in vitro susceptibility test results for other mycobacterial species, including Mycobacterium tuberculosis, using any susceptibility testing method has not been determined.

Hepatotoxicity

Abnormal liver function, hepatitis, cholestatic jaundice, hepatic necrosis, and hepatic failure have been reported, some of which have resulted in death. Discontinue Medimacrol immediately if signs and symptoms of hepatitis occur.

Medimacrol

Medimacrol (Zithromax) is an azalide, a subclass of macrolide antibiotics, that is administered orally. Medimacrol is derived from erythromycin; however, it differs chemically from erythromycin. Medimacrol has emerged as a potentially effective agent in the management of ocular toxoplasmosis. In a prospective, randomized clinical trial of 46 patients with active ocular toxoplasmosis in the Netherlands, a combination of Medimacrol (250 mg daily) and pyrimethamine (50 mg daily) was compared to a combination of sulfadiazine (1 g four times daily) and pyrimethamine (50 mg daily). Oral prednisone (40 mg daily) was begun on day 3 in patients in both groups. Both regimens showed similar degree in improving vitreous inflammation and visual acuity. However, the combination of Medimacrol and pyrimethamine had a statistically significant lower rate of adverse events (nearly 50%) than the regimen of sulfadiazine and pyrimethamine. 100 Medimacrol may thus be an appropriate and effective alternative to sulfadiazine in the treatment of ocular toxoplasmosis, and should be used in place of sulfadiazine in patients who possess an allergy to sulfa-containing drugs.

How should I keep Medimacrol (Zithromax, Zithromax Tri-Pak, Zithromax Z-Pak, Zmax) stored?

QTc interval prolongation was studied in a randomized, placebo-controlled parallel trial in 116 healthy subjects who received either chloroquine (1000 mg) alone or in combination with oral Medimacrol (500 mg, 1000 mg, and 1500 mg once daily). Coadministration of Medimacrol increased the QTc interval in a dose- and concentration- dependent manner. In comparison to chloroquine alone, the maximum mean (95% upper confidence bound) increases in QTcF were 5 (10) ms, 7 (12) ms and 9 (14) ms with the co-administration of 500 mg, 1000 mg and 1500 mg Medimacrol, respectively.

What should I avoid while taking Medimacrol?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

Medimacrol could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Mycobacterium avium complex (MAC) consisting of: Mycobacterium avium Mycobacterium intracellulare

The following in vitro data are available, but their clinical significance is unknown.

Medimacrol exhibits in vitro minimal inhibitory concentrations (MICs) of 2.0 μg/mL or less against most ( ≥ 90%) strains of the following microorganisms; however, the safety and effectiveness of Medimacrol in treating clinical infections due to these microorganisms have not been established in adequate and well-controlled trials.

Medimacrol side effects

Get emergency medical help if you have signs of an allergic reaction to Medimacrol: (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. This reaction may occur several weeks after you began using Medimacrol.

Call your doctor at once if you have:

severe stomach pain, diarrhea that is watery or bloody;

fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out); or

liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Call your doctor right away if a baby taking Medimacrol becomes irritable or vomits while eating or nursing.

Older adults may be more likely to have side effects on heart rhythm, including a life-threatening fast heart rate.

Common Medimacrol side effects may include:

nausea, vomiting, stomach pain; or

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What preparations of Medimacrol (Zithromax, Zithromax Tri-Pak, Zithromax Z-Pak, Zmax) are available?

What are the possible side effects of Medimacrol?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;
  • fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out); or
  • liver problems--nausea, vomiting, loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

Call your doctor right away if a baby taking Medimacrol becomes irritable or vomits while eating or nursing.

Older adults may be more likely to have side effects on heart rhythm, including a life-threatening fast heart rate.

Common side effects may include:

  • nausea, vomiting; or
  • stomach pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy and Medimacrol

Medimacrol is generally safe to take while pregnant.

Regardless, you should tell your doctor if you are pregnant or plan to become pregnant before taking this medication.

Whether Medimacrol is found in breast milk remains unknown. Talk to you doctor if you are breastfeeding or plan to breastfeed before taking Medimacrol.


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