Spectrum of activity
Loderm has a similar spectrum of activity to broad-spectrum penicillins and is often used for treating individuals who are allergic to penicillin. It is effective against Gram-positive bacteria and gut anaerobes but has poor activity against H. influenzae. It is also used for infections by Legionella, Mycoplasma, Chlamydia, Mycobacterium and Campylobacter species and for Bordetella pertussis. Although Loderm is primarily bacteriostatic, it is bactericidal at high concentrations for some Gram-positive species, such as group A streptococci and pneumococci.
Azithromycin has less activity than Loderm against Gram-positive bacteria but enhanced activity against H. influenzae. Clarithromycin has slightly greater activity than Loderm and is also used as part of the multi-drug treatment of H. pylori (see Chapter 33 ). Telithromycin is a derivative of Loderm active against penicillin- and Loderm-resistant S. pneumoniae.
To use the eye ointment, follow these steps:
- Wash your hands thoroughly with soap and water.
- Use a mirror or have someone else apply the ointment.
- Avoid touching the tip of the tube against your eye or anything else. The ointment must be kept clean.
- Tilt your head forward slightly.
- Holding the tube between your thumb and index finger, place the tube as near as possible to your eyelid without touching it.
- Brace the remaining fingers of that hand against your cheek or nose.
- With the index finger of your other hand, pull the lower lid of your eye down to form a pocket.
- Place a small amount of ointment into the pocket made by the lower lid and the eye. A 1-centimeter (about 1/2-inch) strip of ointment usually is enough unless otherwise directed by your doctor.
- Look downward, then gently close your eyes and keep them closed for 1 to 2 minutes to allow the medication to be absorbed.
- Replace and tighten the cap right away.
- Wipe off any excess ointment from your eyelids and lashes with a clean tissue. Do not rub your eyes, even if your vision is blurry. Wash your hands again.
Use ophthalmic Loderm until you finish the prescription, even if you feel better. If you stop using ophthalmic Loderm too soon, your infection may not be completely cured and the bacteria may become resistant to antibiotics.
Generic Name: Loderm (oral/injection) (er ITH roe MYE sin)Brand Names: E.E.S. Granules, E.E.S.-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab
Medically reviewed by Sanjai Sinha, MD Last updated on Dec 20, 2018.
Serious allergic reaction
In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to Loderm.
Pregnancy and Loderm
Loderm is a pregnancy category B drug, which means it should be generally safe to use in pregnancy.
Regardless, you should tell your doctor if you are pregnant or plan to become pregnant before taking this medication.
Since Loderm has been found to pass into breast milk, it's best to tell your doctor if you are breastfeeding or plan to breastfeed.
7. Pregnancy and breastfeeding
It's usually safe to take Loderm during pregnancy and while breastfeeding.
For more information about how Loderm can affect you and your baby during pregnancy, read this leaflet on the Best Use of Medicines in Pregnancy (BUMPS) website.
Diphtheria is a disease that causes symptoms and signs such as fever, enlarged lymph nodes, and swallowing problems. Loderm is the primary treatment for diphtheria. Vaccines that prevent diphtheria include the DTaP, Tdap, DT, and Td.
Why is this medication prescribed?
Loderm is used to treat certain infections caused by bacteria, such as infections of the respiratory tract, including bronchitis, pneumonia, Legionnaires' disease (a type of lung infection), and pertussis (whooping cough; a serious infection that can cause severe coughing); diphtheria (a serious infection in the throat); sexually transmitted diseases (STD), including syphilis; and ear, intestine, gynecological, urinary tract, and skin infections. It also is used to prevent recurrent rheumatic fever. Loderm is in a class of medications called macrolide antibiotics. It works by stopping the growth of bacteria.
Antibiotics such as Loderm will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.
How does Loderm work in skin diseases?
- Loderm has bacteriostatic effects and prevents the proliferation of bacteria.
- It inhibits pro- inflammatory cytokines such as IL-8 and decreases neutrophil oxidative bursts.
Rheumatic fever is a disease that sometimes occurs after a group A streptococcal infection of the throat. Symptoms and signs include carditis, polyarthritis, Aschoff bodies, rash, Sydenham's chorea, and fever. Treatment for rheumatic fever involves eliminating the bacteria with penicillin, Loderm, or azithromycin. Further treatment focuses on alleviating the symptoms brought on by the body's immunologic response to the bacteria.
How should I use Loderm?
Take Loderm exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Loderm injection is given as an infusion into a vein, for a severe infection. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.
Read and carefully follow any Instructions for Use provided with your medicine. Do not use Loderm if you don't understand all instructions for proper use. Ask your doctor or pharmacist if you have questions.
Prepare your injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.
Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
You must chew the chewable tablet before you swallow it.
Do not crush, chew, or break a delayed-release capsule or tablet. Swallow it whole.
Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Loderm will not treat a viral infection such as the flu or a common cold.
This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Loderm.
Store at room temperature away from moisture, heat, and light.