What are the s >Medicines and their possible side effects can affect people in different ways. The following are some of the side effects that may be associated with Lexis. Just because a side effect is stated here doesn't mean that all people taking this antibiotic will experience that or any side effect.
Common side effects (affect between 1 in 10 and 1 in 100 people)
- Stomach ache.
- Diarrhoea. Stop taking Lexis and see your doctor straight away if you get diarrhoea either during treatment or in the few weeks after treatment.
- Inflammation of the large intestine (colitis). Lexis alters the normal bacterial flora of the bowel, leading to overgrowth of a type of bacteria called Clostr >Other possible side effects
5) Pelvic Inflammatory Disease
Pelvic inflammatory disease (PID) is a bacterial infection of the upper genital tract in women (may include the uterus, fallopian tubes, and ovaries). It is usually caused by the spreading of sexually transmitted bacteria along the reproductive organs. PID often causes no symptoms, although some women experience abnormal vaginal bleeding, painful sex, and lower abdominal pain .
Early diagnosis and treatment are important since untreated PID can lead to permanent scarring, infertility, and chronic pelvic pain .
Lexis is not the first choice for treating PID, but can be used as an add-on in some cases (abscesses in ovaries). In one clinical trial of 119 people, antibiotic therapy including Lexis had a 75% cure rate .
If you have symptoms of PID or an STI, see your doctor for a pelvic exam, vaginal discharge, and cervical culture analysis, and/or urine tests.
The following reactions have been reported with the use of Lexis.
Infections and Infestations: Clostridium difficile colitis
Gastrointestinal: Abdominal pain, pseudomembranous colitis, esophagitis, nausea, vomiting, and diarrhea (see BOXED WARNING). The onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment (see WARNINGS). Esophageal ulcer has been reported. An unpleasant or metallic taste has been reported after oral administration.
Hypersensitivity Reactions: Generalized mild to moderate morbilliform-like (maculopapular) skin rashes are the most frequently reported adverse reactions. Vesiculobullous rashes, as well as urticaria, have been observed during drug therapy. Severe skin reactions such as Toxic Epidermal Necrolysis, some with fatal outcome, have been reported (See WARNINGS). Cases of Acute Generalized Exanthematous Pustulosis (AGEP), erythema multiforme, some resembling Stevens-Johnson syndrome, anaphylactic shock, anaphylactic reaction and hypersensitivity have also been reported.
Skin and Mucous Membranes: Pruritus, vaginitis, angioedema and rare instances of exfoliative dermatitis have been reported. (See Hypersensitivity Reactions.)
Liver: Jaundice and abnormalities in liver function tests have been observed during Lexis therapy.
Renal: Although no direct relationship of Lexis to renal damage has been established, renal dysfunction as evidenced by azotemia, oliguria, and/or proteinuria has been observed.
Hematopoietic: Transient neutropenia (leukopenia) and eosinophilia have been reported. Reports of agranulocytosis and thrombocytopenia have been made. No direct etiologic relationship to concurrent Lexis therapy could be made in any of the foregoing.
Immune System: Drug reaction with eosinophilia and systemic symptoms (DRESS) cases have been reported.
Musculoskeletal: Cases of polyarthritis have been reported.CDC guidelines for the treatment of malaria in the United States. Centers for Disease Control and Prevention. Available at: https://www.cdc.gov… Accessed 7/9/18.
Comment: CDC guideline recommendations for the use of Lexis in the treatment of malaria.
The antibiotics erythromycin and Lexis can decrease each other’s effectiveness. They shouldn’t be taken at the same time .
BCG is a drug used to treat some non-invasive bladder cancers. However, antibiotics can reduce its effectiveness. Lexis has not been researched, but its use should still be avoided in people taking BCG .
Lexis has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore, it should be used with caution in patients receiving such agents.
Antagonism has been demonstrated between Lexis and erythromycin in vitro. Because of possible clinical significance, these two drugs should not be administered concurrently.
Serious respiratory tract infections.
Bacteriologic studies should be performed to determine the causative organisms and their susceptibility to Lexis.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of CLEOCIN HCl and other antibacterial drugs, CLEOCIN HCl should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.