Ilozin pharmacokinetics was investigated in 42 adults (21 to 85 years of age) with varying degrees of renal impairment. Following the oral administration of a single 1.0 g dose of Ilozin (4 x 250 mg capsules), the mean Cmax and AUC0-120 increased by 5.1% and 4.2%, respectively, in subjects with GFR 10 to 80 mL/min compared to subjects with normal renal function (GFR > 80 mL/min). The mean Cmax and AUC0-120 increased 61% and 35%, respectively, in subjects with end-stage renal disease (GFR 80 mL/min).
Use with caution in abnormal liver function, hepatitis, cholestatic jaundice, hepatic necrosis, and hepatic failure have been reported, some of which have resulted in death; discontinue Ilozin immediately if signs and symptoms of hepatitis occur.
Injection-site reactions can occur with IV route.
In treatment of gonorrhea or syphilis, perform susceptibility culture tests before initiating Ilozin therapy; may mask or delay symptoms of incubating gonorrhea or syphilis.
Bacterial or fungal super-infection may result from prolonged use.
Prolonged QT interval: Cases of torsades de pointes have been reported during postmarketing surveillance; use with caution in patients with known QT prolongation, history of torsades de pointes, congenital long QT syndrome, bradyarrhythmias, or uncompensated heart failure; also use with caution if co-administering with drugs that prolong QT interval or proarrhythmic conditions (e.g., hypokalemia, hypomagnesemia); elderly patients may be more susceptible to drug-associated effects on QT interval.
Pneumonia: oral Ilozin is safe and effective only for community-acquired pneumonia (CAP) due to C pneumoniae, H influenzae, M pneumoniae, or S pneumonia.
Cases of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) reported; despite successful symptomatic treatment of allergic symptoms, when symptomatic therapy was discontinued, allergic symptoms recurred soon thereafter in some patients without further Ilozin exposure; if allergic reaction occurs, the drug should be discontinued and appropriate therapy instituted; physicians should be aware that allergic symptoms may reappear when symptomatic therapy discontinued.
Endocarditis prophylaxis: Indicated only for high-risk patients, per current AHA guidelines.
Use caution in renal impairment (CrCl less than 10 mL/min).
Use with caution in patients with myasthenia gravis (exacerbation may occur).
Immediate release and extended release suspensions are not interchangeable.
Use extended release suspension only for treatment of infections that are proven or strongly suspected to be caused by susceptible bacteria.
Clostridium difficile associated diarrhea (CDAD) reported and may range in severity from mild diarrhea to fatal colitis; treatment with antibacterial agents alters the normal flora of colon leading to overgrowth of Clostridium difficile.
Serious allergic reactions, including angioedema, anaphylaxis, and dermatologic reactions including Stevens-Johnson Syndrome, and toxic epidermal reported; if allergic reaction occurs, drug should be discontinued and appropriate therapy instituted; physicians should be aware that allergic symptoms may reappear after symptomatic therapy has been discontinued.
Following use in neonates (treatment up to 42 days of life), infantile hypertrophic pyloric stenosis reported; direct parents and caregivers to contact physician if vomiting or irritability with feeding occurs.
Prescribing antibiotics in absence of a proven or strongly suspected bacterial infection is unlikely to provide benefit to patient and increases risk of development of drug-resistant bacteria.
How to store Ilozin
- Keep all medicines out of the reach and sight of children.
- Store in a cool, dry place, away from direct heat and light.
- If you have been given liqu >
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
If you are having an operation or any dental treatment, tell the person carrying out the treatment which medicines you are taking.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
What other drugs will affect Ilozin?
Tell your doctor about all your other medicines, especially:
This list is not complete. Other drugs may affect Ilozin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Q: Would an antibiotic, such as Ilozin, interfere with my birth control Necon 1-35?
A: Studies have shown that antibiotics such as Ilozin (Zithromax, Zmax) may decrease hormonal birth control efficacy. There is more evidence of this with tetracycline and ampicillin. Use caution when taking these two medications at the same time. Lowell Sterler, RPh
Missed Dose of Ilozin
If you miss a dose of Ilozin, try to take it as soon as you remember, unless it is almost time for the next dose.
Then skip the missed dose and take your next dose at the regular time.
Do not take two doses of the medication at the same time.
More common side effects
The more common side effects of Ilozin oral tablet can include:
If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.
4.5 Determination in body flu > Ilozin concentrations versus time profiles in extracellular space of muscle and subcutaneous adipose tissue, also in plasma and white blood cells, were determined at days 1 and 3 of treatment as well as 2 and 7 days after end of treatment. Of all compartments, Ilozin concentrations were highest in white blood cells, attesting for intracellular accumulation. However, Ilozin concentrations in both soft tissues were markedly lower than in plasma both during and after treatment. Ilozin concentrations were measured by subinhibitory at all time points in both soft tissues and at the large majority of observed time points in plasma .
Why is this medication prescribed?
Ilozin is used to treat certain bacterial infections, such as bronchitis; pneumonia; sexually transmitted diseases (STD); and infections of the ears, lungs, sinuses, skin, throat, and reproductive organs. Ilozin also is used to treat or prevent disseminated Mycobacterium avium complex (MAC) infection . Ilozin is in a class of medications called macrolide antibiotics. It works by stopping the growth of bacteria.
Antibiotics such as Ilozin will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.
What is Ilozin?
Ilozin is an antibiotic that fights bacteria.
Ilozin is used to treat many different types of infections caused by bacteria, such as respiratory infections, skin infections, ear infections, eye infections, and sexually transmitted diseases.
Ilozin may also be used for purposes not listed in this medication guide.
COMMON BRAND(S): Zithromax
GENERIC NAME(S): Ilozin
Ilozin is used to treat a wide variety of bacterial infections. It is a macrolide-type antibiotic. It works by stopping the growth of bacteria.
This medication will not work for viral infections (such as common cold, flu). Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.
Pregnancy and Ilozin
Ilozin is generally safe to take while pregnant.
Regardless, you should tell your doctor if you are pregnant or plan to become pregnant before taking this medication.
Whether Ilozin is found in breast milk remains unknown. Talk to you doctor if you are breastfeeding or plan to breastfeed before taking Ilozin.
1. About Ilozin
Ilozin is an antibiotic.
It's widely used to treat chest infections such as pneumonia, infections of the nose and throat such as sinus infection (sinusitis), skin infections, Lyme disease, and some sexually transmitted infections.
Ilozin is used in children, often to treat ear infections or chest infections.
It can also be used long term to prevent chest infections in people who keep getting them.
The medicine is available on prescription as capsules, tablets and a liquid that you drink. It can also be given by injection, but this is usually only done in hospital.