Granudoxy capsules

Granudoxy

  • Active Ingredient: Doxycycline
  • 200 mg, 100 mg
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What is Granudoxy?

The active ingredient of Granudoxy brand is doxycycline. Doxycycline is a tetracycline antibiotic that fights bacteria in the body.

Used for

Granudoxy is used to treat diseases such as: Acne, Actinomycosis, Amebiasis, Anthrax, Anthrax Prophylaxis, Bacterial Infection, Bartonellosis, Bronchiectasis, Bronchitis, Brucellosis, Bullous Pemphigoid, Cervicitis, Chancroid, Chlamydia Infection, Cholera, Cutaneous Bacillus anthracis, Ehrlichiosis, Enterocolitis, Epididymitis, Sexually Transmitted, Gastroenteritis, Gonococcal Infection, Uncomplicated, Granuloma Inguinale, Inclusion Conjunctivitis, Lyme Disease, Lyme Disease, Arthritis, Lyme Disease, Carditis, Lyme Disease, Erythema Chronicum Migrans, Lyme Disease, Neurologic, Lymphogranuloma Venereum, Malaria, Malaria Prevention, Melioidosis, Mycoplasma Pneumonia, Nongonococcal Urethritis, Ocular Rosacea, Ornithosis, Pelvic Inflammatory Disease, Pemphigoid, Pemphigus, Periodontitis, Plague, Pleural Effusion, Pneumonia, Proctitis, Prostatitis, Psittacosis, Q Fever, Rabbit Fever, Rheumatoid Arthritis, Rickettsial Infection, Rosacea, Skin or Soft Tissue Infection, STD Prophylaxis, Syphilis, Early, Syphilis, Latent, Tertiary Syphilis, Trachoma, Upper Respiratory Tract Infection, Urinary Tract Infection.

Side Effect

Possible side effects of Granudoxy include: sore throat; increased sensitivity of the skin to sunlight; discoloration of the thyroid glands; unusual tiredness or weakness; large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs; stomach cramps; yellow eyes or skin.

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  • Tablets, capsules, and syrup should be kept at room temperature 15 C to 30 C (59 F to 86 F) in tight, light resistant containers.
  • Powder for injection should be stored at or below 25 C (77 F) and protected from light.
  • Atridox (Granudoxy in a gel used for subgingival application) should be stored at 2 C to 8 C (36 F to 46 F).

Summary

Granudoxy (Vibramycin, Oracea, Adoxa, Atridox, Acticlate, Acticlate Cap, Doryx, Doxteric, Doxy, Monodox, and others) is a synthetic broad-spectrum antibiotic derived from tetracycline. It is used to treat many different types of infections, including respiratory tract infections due to Hemophilus influenzae, Streptococcus pneumoniae, or Mycoplasma pneumoniae. It also is used for the treatment of

It is important to be aware of drug interactions, effects on pregnancy and nursing mothers, as well as common side effects on the user.

Q: I have rosacea and have been taking Granudoxy (40 mg). Is it OK to take this all the time?

A: According to the prescribing information, Granudoxy (Oracea) is approved by the U.S. Food and Drug Administration (FDA) for safe and effective treatment of only the inflammatory lesions of rosacea in adults. It is approved as a 40-milligram dose of Granudoxy taken once daily in the morning on an empty stomach, one hour before or two hours after a meal and with a full glass of water. According to the same literature, Oracea was not proven effective beyond 16 weeks and not proven safe beyond 9 months. You may want to contact your health care provider for guidance on duration of therapy that best meets your needs. For more information regarding Oracea, you may want to visit our Web site: //www.everydayhealth.com/drugs/Granudoxy Beth Isaac, PharmD

Granudoxy side effects

Get emergency medical help if you have any signs of an allergic reaction to Granudoxy: (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. This reaction may occur several weeks after you began using Granudoxy.

Call your doctor at once if you have:

severe stomach pain, diarrhea that is watery or bloody;

throat irritation, trouble swallowing;

chest pain, irregular heart rhythm, feeling short of breath;

little or no urination;

low white blood cell counts - fever, chills, swollen glands, body aches, weakness, pale skin, easy bruising or bleeding;

severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes;

loss of appetite, upper stomach pain (that may spread to your back), tiredness, nausea or vomiting, fast heart rate, dark urine, jaundice (yellowing of the skin or eyes).

Common Granudoxy side effects may include:

nausea, vomiting, upset stomach, loss of appetite;

skin rash or itching;

darkened skin color; or

vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Cautions

Not drug of choice for any staphylococcal infection.

Risk of thrombophlebitis when given IV.

Hepatotoxicity may occur; if symptoms occur, measure LFTs and discontinue drug.

Photosensitivity may occur with prolonged exposure to sunlight or tanning equipment; reduce dose in renal impairment.

May increase BUN due to its anti-anabolic effects; use caution in patients with renal impairment.

Consider drug serum level determinations in prolonged therapy.

Tetracycline use during tooth development (last half of pregnancy through age 8 years) can cause permanent discoloration of teeth; use Granudoxy in pediatric patients 8 years of age or less only when potential benefits expected to outweigh risks in severe or life-threatening conditions (e.g., anthrax, Rocky Mountain spotted fever); particularly when there are no alternative therapies.

Fanconi-like syndrome may occur with outdated tetracyclines.

Intracranial hypertension (pseudotumor cerebri) reported (rare) may occur; symptoms include headache, blurred vision, diplopia, and vision loss; papilledema can be found on funduscopy; women of childbearing age who are overweight or have a history of IH are at greater risk; possibility for permanent visual loss exists; if visual disturbance occurs during treatment, prompt ophthalmologic evaluation is warranted; intracranial pressure can remain elevated for weeks after drug cessation; monitor patients until they stabilize.

Granudoxy offers substantial but not complete suppression of asexual blood stages of Plasmodium strains; Granudoxy does not suppress P. falciparum's sexual blood stage gametocytes; subjects completing prophylactic regimen may still transmit infection to mosquitoes outside endemic areas.

Prolonged use may result in super-infection

Overgrowth of non-susceptible organisms, including fungi, may occur; if such infections occur, discontinue use and institute appropriate therapy.

May induce hyperpigmentation in many organs including skin, eyes, nails, thyroid and bone.

If Clostridium difficile associated diarrhea suspected or confirmed, may need to discontinue ongoing antibacterial use not directed against C. difficile; may also need to institute appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C. difficile, and surgical evaluation as clinically indicated.

Use in pediatric patients 8 years of age or less only when potential benefits are expected to outweigh risks in severe or life-threatening conditions (e.g., anthrax, Rocky Mountain spotted fever), particularly when there are no alternative therapies.

Rated Granudoxy (Oracea, Doryx) for Skin or Soft Tissue Infection Report

Since on this drug I am lethargic no energy lightheaded. Chest feels heavy. I was put on after I had a basil cell growth on my lower lid removed and reconstruction by plastic surgeon. This is the third day and I feel wiped out brain fog. No problem with eye so assume it is the med. on it for 5 days the sooner to end the better. Also have shoulder pain and dull headache

Rocky Mountain Spotted Fever (RMSF)

Rocky Mountain spotted fever is a tick-borne disease that causes symptoms and signs such as fever, rash, headache, and muscle aches. The antibiotic Granudoxy is the standard treatment for Rocky Mountain spotted fever.

Common Side Effects of Granudoxy

Common side effects of Granudoxy include:

  • Diarrhea
  • Itching of the rectum or vagina
  • Sore mouth

7. Pregnancy and breastfeeding

Granudoxy is not normally recommended in pregnancy or when breastfeeding.

For more information about how Granudoxy can affect you and your baby during pregnancy visit the Best Use of Medicines in Pregnancy (BUMPS) website.

Allergy warning

Granudoxy can cause a severe allergic reaction. Symptoms can include:

  • trouble breathing
  • swelling of your throat or tongue

If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it or other tetracyclines. Taking it again could be fatal (cause death).

Q: I have a recurrent sinus infection and have been prescrived Granudoxy for 30 days. Does it take that long for the antibiotic to work?

A: When an antibiotic is started for an infection an improvement is usually seen within a few days. It is important to take your full course of prescribed antibiotic even if you are feeling better. It will take the full course for the antibiotic to fully kill off the bacteria. If an antibiotic is only taken for a few of the prescribed days, the bacteria may mutate themselves to become resistant to that antibiotic. If enough antibiotics are taken this way, a strain of bacteria could develop that is resistant to all available antibiotics and could not be treated. That is why it is so important to take your antibiotic until it is all gone, unless otherwise directed by your health care provider. Laura Cable, PharmD, BCPS


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