Drug interactions overview
- Concomitant use with Fixim and carbamazepine may elevate carbamazepine levels reported in postmarketing experience
- Administration of Fixim may result in a false-positive reaction for glucose in the urine using Clinitest®, Benedict’s solution, or Fehling’s solution; use glucose tests based on enzymatic glucose oxidase reactions (such as Clinistix® or TesTape®) be used
- A false-positive direct Coombs test reported during treatment with other cephalosporins; therefore, it should be recognized that a positive Coombs test may be due to the drug
- Reproduction studies have been performed in mice and rats at doses equivalent to 40 and 80 times, respectively, adult human recommended dose and have revealed no evidence of harm to the fetus due to Fixim
Fixim is a semisynthetic, cephalosporin antibacterial for oral administration. Chemically, it is (6R,7R)-7--8-oxo-3-vinyl-5-thia-1-azabicyclo oct-2-ene-2-carboxylic acid, 7 2 -(Z)- trihydrate.
Molecular weight = 507.50 as the trihydrate. Chemical Formula is C16H15N5O7S2.3H2O
The structural formula for Fixim is:
- Inactive ingredients contained in SUPRAX ® (Fixim) 400 mg tablets USP are: dibasic calcium phosphate, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, pregelatinized starch, titanium dioxide, and triacetin.
- Inactive ingredients contained in SUPRAX ® (Fixim) 400 mg capsules are: colloidal silicon dioxide, crospovidone, low substituted hydroxy propyl cellulose, magnesium stearate, and mannitol. The capsule shell contains the following inactive ingredients: ferric oxide black, ferric oxide red, gelatin, potassium hydroxide, propylene glycol, shellac, sodium lauryl sulfate, and titanium dioxide.
- Inactive ingredients contained in SUPRAX ® (Fixim) 100 mg or 150 mg or 200 mg chewable tablets are: aspartame, colloidal silicon dioxide, crospovidone, FD&C Red # 40 Aluminium Lake, low substituted hydroxypropyl cellulose, magnesium stearate, mannitol, fantasy flavor permaseal, and tutti frutti flavor.
- Inactive ingredients contained in SUPRAX ® (Fixim) powder for oral suspension USP are: colloidal silicon dioxide, sodium benzoate, strawberry flavor, sucralose (only in 500 mg/5 mL strength), sucrose, and xanthan gum.
What Is Fixim?
Fixim is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in your body.
Fixim is used to treat many different types of infections caused by bacteria.
Fixim may also be used for purposes not listed in this medication guide.
You should not take this medicine if you are allergic to Fixim, or to similar antibiotics, such as Ceftin, Cefzil, Keflex, Omnicef, and others. Tell your doctor if you are allergic to penicillins.
You should not take this medicine if you are allergic to Fixim or to other cephalosporin antibiotics, such as:
- cefaclor (Raniclor);
- cefadroxil (Duricef);
- cefazolin (Ancef);
- cefdinir (Omnicef);
- cefditoren (Spectracef);
- cefpodoxime (Vantin);
- cefprozil (Cefzil);
- ceftibuten (Cedax);
- cefuroxime (Ceftin);
- cephalexin (Keflex);
- cephradine (Velosef); and others.
To make sure Fixim is safe for you, tell your doctor if you are allergic to any drugs, especially penicillins.
The chewable tablet form may contain phenylalanine. Talk to your doctor before using this form of Fixim if you have phenylketonuria (PKU).
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.
It is not known whether Fixim passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding. You may need to stop nursing while you are taking Fixim.
The Fixim suspension (liquid) contains sucrose. Talk to your doctor before using this form of Fixim if you have diabetes.
When not to use?
Contraindications of Fixim
- Allergy : This medicine is not recommended for use if you have a known allergy to Fixim or any other Beta lactam antibiotics.
What is Fixim, and how does it work (mechanism of action)?
Fixim is a semi-synthetic (partially man-made), oral antibiotic in the cephalosporin family of antibiotics. The cephalosporin family includes cephalexin (Keflex), cefaclor (Ceclor), cefuroxime (Zinacef), cefpodoxime (Vantin), cefprozil (Cefzil), and many injectable forms. Like other cephalosporins, Fixim stops bacteria from multiplying by preventing bacteria from forming the walls that surround them. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together; most bacteria cannot survive without a cell wall. Fixim is active against a very wide spectrum of bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes (the cause of strep throat), Hemophilus influenzae, Moraxella catarrhalis, E. coli, Klebsiella, Proteus mirabilis, Salmonella, Shigella, and Neisseria gonorrhoeae. The FDA approved Fixim in April 1989.
This medicine is not recommended for use if you have a known allergy to Fixim or Beta-lactam Antibiotics. Seek immediate medical attention if you experience any allergic symptoms like rash, itching, nausea or vomiting, swelling of lips, hands, and feet.
Clostridium difficile-associated Diarrhea
Discontinue the use of this medicine as per the doctor’s instructions if severe diarrhea occurs after receiving Fixim. This medicine may cause an imbalance in the microbial flora of the large intestine, decreasing the gut-friendly bacteria and promoting the growth of a bacteria called Clostridium difficile, resulting in severe diarrhea.
This medicine should be used with caution in patients with bleeding disorders due to the increased risk of excessive bleeding. Regular monitoring of prothrombin time is necessary in such cases. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
This medicine should be used with caution in patients with an impaired kidney function due to the increased risk of severe adverse effects. Appropriate dose adjustments are to be made based on the CrCl or eGFR.
Use in pediatrics
This medicine is not recommended for use in children less than 6 months of age since the safety and efficacy of use are not clinically established in this particular age group.
Usage of Fixim without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug resistant.
Other uses for this medicine
Fixim is also sometimes used to treat sinus infections in penicillin allergic patients, pneumonia, shigella (an infection that causes severe diarrhea), salmonella (an infection that causes severe diarrhea), and typhoid fever (a serious infection that is common in developing countries). Talk to your doctor about the risks of using this medication for your condition.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What are some things I need to know or do while I take Fixim Capsules and Tablets?
- Tell all of your health care providers that you take this medicine (Fixim capsules and tablets). This includes your doctors, nurses, pharmacists, and dentists.
- Very bad and sometimes deadly allergic reactions have rarely happened. Talk with your doctor.
- Do not use longer than you have been told. A second infection may happen.
- If you have high blood sugar (diabetes) and test your urine glucose, talk with your doctor to find out which tests are best to use.
- This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take this medicine (Fixim capsules and tablets).
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine (Fixim capsules and tablets) while you are pregnant.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
Fixim During Pregnancy and Breastfeeding
Fixim has been assigned to pregnancy category B by the FDA. Animal studies failed to reveal evidence of fetal harm. There are no controlled data in human pregnancy. Fixim is only recommended for use during pregnancy when benefit outweighs risk.
There are no data on the excretion of Fixim into human milk. Other cephalosporins are excreted into human milk in small amounts. While adverse effects are unlikely, the infant should be monitored closely.