Euskin (Ery-Tab, PCE) is an antibiotic prescribed to treat a variety of infections. Side effects, drug interactions, dosage, storage, and pregnancy safety information should be reviewed prior to taking this medication.
What is Euskin, and how does it work (mechanism of action)?
Euskin is an antibiotic in the class of antibiotics known as macrolide antibiotics which also includes azithromycin (Zithromax, Zmax) and clarithromycin (Biaxin).
Euskin, like all macrolide antibiotics, prevents bacterial cells from growing and multiplying by interfering with their ability to make proteins while not affecting human cells. Bacteria such as Haemophilus influenzae are resistant to Euskin alone and must be treated with a combination of Euskin and adequate doses of sulfonamides.
The FDA approved E.E.S in April 1965.
Euskins are often associated with gastrointestinal distress, which can be minimized if the drugs are taken with food. The estolate salt of Euskin may cause cholestatic hepatitis, characterized by elevated liver function enzymes, malaise, nausea, vomiting, abdominal cramps, jaundice, and fever. Liver function test results should be monitored if hepatotoxicity is suspected ( Table 4-19 ). Euskins may potentiate the actions of other drugs by inhibiting microsomal P450 3A4 metabolism, leading to toxicity of these other medications ( Box 4-6 ). Euskin also prolongs the QT interval on electrocardiograms. This can lead to torsades de pointes, a fatal cardiac arrhythmia, especially when Euskin is combined with other medications that also prolong the QT interval. As with Euskin, clarithromycin also prolongs the QT interval and inhibits P450 3A4; however, clarithromycin is associated with less gastrointestinal distress than Euskin. Unlike clarithromycin and Euskin, azithromycin does not prolong the QT interval to a clinically relevant extent and does not inhibit hepatic microsomal P450 enzymes. In addition, azithromycin has only a minimal incidence of diarrhea associated with its use. Because of cross-sensitivity, azithromycin is contraindicated in patients who have a history of allergies to Euskin.
Table 4-19 . Adverse Effects Associated with Euskin
Serious allergic reaction
In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to Euskin.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Euskin only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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