Ethide

Ethide

  • Active Ingredient: Ethionamide
  • 250 mg
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What is Ethide?

The active ingredient of Ethide brand is ethionamide. Ethionamide is an antibiotic that fights bacteria.

Used for

Ethide is used to treat diseases such as: Tuberculosis, Active.

Side Effect

Possible side effects of Ethide include: general tiredness and weakness; decreased vision; difficulty in concentrating; tightness in the chest; metallic taste.

How to Buy Ethide online?

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How is this medicine (Ethide) best taken?

Use Ethide as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take with or without food. Take with food if it causes an upset stomach.
  • If you have upset stomach, throwing up, diarrhea, or are not hungry, talk with your doctor. There may be ways to lower these side effects.
  • To gain the most benefit, do not miss doses.
  • Keep taking Ethide as you have been told by your doctor or other health care provider, even if you feel well.
  • Take vitamin B6 (pyridoxine) as you were told by your doctor.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

How should I take Ethide?

Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using Ethide.

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

You may take Ethide with or without food.

Ethide may be taken with food if it upsets your stomach.

You may need frequent blood tests to check your liver and thyroid function. You may also need frequent vision exams.

If you have diabetes, check your blood sugar carefully while taking Ethide.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Ethide will not treat a viral infection such as the flu or a common cold.

Store at room temperature away from moisture and heat.

Renal Impairment

End-stage renal disease on hemodialysis: 250-500 mg/day

CrCl Enter a drug name and Ethide

What other drugs will affect Ethide (Trecator)?

Other drugs may interact with Ethide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Isoniaz > Isoniaz >Ethide are common anti-tuberculosis drugs; Ethide is a structural analogue of isoniazid. As a result, these two drugs have a similar metabolism, toxicity and molecular targets, causing concern for potential cross-reactivity reactions. This concern was addressed in a study with 69 patients on isoniazid treatment who developed adverse skin reactions; serious adverse reactions in 25 patients included drug rash with eosinophilia and systemic symptoms (DRESS), Stevens–Johnson syndrome or toxic epidermal necrolysis. Isoniazid was discontinued in these cases and Ethide treatment started when the initial symptoms had subsided. These 25 patients then underwent rechallenge with isoniazid; a rechallenge reaction occurred in 20 patients. At the same time, 5 patients from the same group reacted to Ethide. It was noted that none of the patients who reacted to isoniazid or Ethide showed cross-reactivity to the other drug .

Adverse Reactions.

Gastrointestinal distress with nausea and vomiting frequently leads to poor compliance and drug discontinuance. Various neurologic disorders have been caused by Ethide , including peripheral neuropathy and psychiatric disturbances. Neurologic side effects have been reported to be alleviated by pyridoxine or nicotinamide. Reversible hepatotoxicity occurs in approximately 5% of Ethide recipients. A hypersensitivity-type rash and poor diabetic control are infrequent complications. Its usage is limited also by a high frequency of severe gastrointestinal intolerance. Hypothyroidism is a recognized complication of Ethide use and is more common when Ethide is combined with PAS. Patients should have periodic screening for hypothyroidism in patients receiving Ethide long term.

What do I need to tell my doctor BEFORE I take Ethide?

  • If you have an allergy to Ethide or any other part of Ethide.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have liver disease.

This is not a list of all drugs or health problems that interact with Ethide.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Ethide with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

7.24.6.2.1 Sites and mechanisms of action

Isoniaz >Ethide , and prothionamide are all prodrugs. Isoniazid is activated by a catalase peroxidase enzyme (KatG). Mutations in KatG account for the majority of isoniazid resistance. The active species of isoniazid appears to have multiple cellular targets. 52 The primary target of isoniazid is believed to be InhA, a NADH-dependent enoyl acyl carrier protein reductase involved in the synthesis of mycolic acid. 53,54 The activated species, presumably an isonicotinic acyl radical, forms an adduct with the NAD radical. The resulting isonicotinic acyl-NADH adduct (INA) binds to InhA, and inhibits the synthesis of mycolic acid, an essential cell wall component of M. tuberculosis ( Figure 6 ). 55

Ethionam >

Avoid drinking alcohol while taking Ethide.

Other drugs may interact with Ethide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Cautions

Use caution in diabetes mellitus, thyroid disease, hepatic impairment

HIV patients may have malabsorption syndrome

Used as monotherapy in the treatment of tuberculosis results in rapid development of resistance; give suitable companion drug or drugs; base the choice on results of susceptibility testing; therapy may be initiated prior to receiving results of susceptibility tests as deemed appropriate by physician; administer with at least one, sometimes two, other drugs to which organism is known to be susceptible

Prescribing drug in the absence of a proven or strongly suspected bacterial infection indication is unlikely to provide benefit to patient and increases risk of development of drug-resistant bacteria

Ethide may potentiate adverse effects of other antituberculous drugs administered concomitantly

Perform ophthalmologic examinations (including ophthalmoscopy) before and periodically during therapy

Excessive ethanol ingestion should be avoided; psychotic reaction reported


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