How should this medicine be used?
Ophthalmic Eryzole comes as an ointment to apply to the eyes. It is usually applied up to six times a day for eye infections. Ophthalmic Eryzole is usually applied one time in the hospital soon after delivery to prevent eye infections in newborn babies. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use Eryzole eye ointment exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.
You should expect your symptoms to improve during your treatment. Call your doctor if your symptoms get worse or do not go away, or if you develop other problems with your eyes during your treatment.
COMMON BRAND(S): Ilotycin
GENERIC NAME(S): Eryzole
OTHER NAME(S): Eryzole Ointment
This medication is used to treat certain eye infections (such as conjunctivitis). It is also used to prevent certain eye infections in newborns. It belongs to a class of drugs known as macrolide antibiotics. Eryzole works by stopping the growth of bacteria.
This medication treats only bacterial eye infections. It will not work for other types of eye infections. Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.
Serious Side Effects of Eryzole
- Severe inflammation of the colon caused by antibiotic use (pseudomembranous colitis)
- Inflammation of the liver
- Confusion or hallucinations
- Kidney inflammation or infection
- Abdominal pain
If you have diarrhea, gas, or begin vomiting, stop taking Eryzole immediately and call your doctor.
How to take it
Swallow Eryzole tablets or capsules whole with a drink of water. Do not chew or break them.
There's a liquid Eryzole for children and people who find it difficult to swallow tablets.
If you or your child are taking Eryzole as a liquid, it'll usually be made up for you by your pharmacist. The medicine will come with a syringe or spoon to help you take the right amount. If you don't have a syringe or spoon, ask your pharmacist for one. Do not use a kitchen teaspoon as it will not give the right amount.
7. Pregnancy and breastfeeding
It's usually safe to take Eryzole during pregnancy and while breastfeeding.
For more information about how Eryzole can affect you and your baby during pregnancy, read this leaflet on the Best Use of Medicines in Pregnancy (BUMPS) website.
DOSAGE AND ADMINISTRATION
Optimal blood levels are obtained when Eryzole Base Filmtab (Eryzole tablets) tablets are given in the fasting state (at least 1/2 hour and preferably 2 hours before meals).
Adults: The usual dosage of Eryzole Base Filmtab (Eryzole tablets) is one 250 mg tablet four times daily in equally spaced doses or one 500 mg tablet every 12 hours. Dosage may be increased up to 4 g per day according to the severity of the infection. However, twice-a-day dosing is not recommended when doses larger than 1 g daily are administered.
Children: Age, weight, and severity of the infection are important factors in determining the proper dosage. The usual dosage is 30 to 50 mg/kg/day, in equally divided doses. For more severe infections this dosage may be doubled but should not exceed 4 g per day.
In the treatment of streptococcal infections of the upper respiratory tract (e.g., tonsillitis or pharyngitis), the therapeutic dosage of Eryzole should be administered for at least ten days.
The American Heart Association suggests a dosage of 250 mg of Eryzole orally, twice a day in long-term prophylaxis of streptococcal upper respiratory tract infections for the prevention of recurring attacks of rheumatic fever in patients allergic to penicillin and sulfonamides. 3
Conjunctivitis of the newborn caused by Chlamydia trachomatis: Oral Eryzole suspension 50 mg/kg/day in 4 divided doses for at least 2 weeks. 3
Pneumonia of infancy caused by Chlamydia trachomatis: Although the optimal duration of therapy has not been established, the recommended therapy is oral Eryzole suspension 50 mg/kg/day in 4 divided doses for at least 3 weeks.
Urogenital infections during pregnancy due to Chlamydia trachomatis: Although the optimal dose and duration of therapy have not been established, the suggested treatment is 500 mg of Eryzole by mouth four times a day on an empty stomach for at least 7 days. For women who cannot tolerate this regimen, a decreased dose of one Eryzole 500 mg tablet orally every 12 hours or 250 mg by mouth four times a day should be used for at least 14 days. 5
For adults with uncomplicated urethral, endocervical, or rectal infections caused by Chlamydia trachomatis, when tetracycline is contraindicated or not tolerated: 500 mg of Eryzole by mouth four times a day for at least 7 days. 5
For patients with nongonococcal urethritis caused by Ureaplasma urealyticum when tetracycline is contraindicated or not tolerated: 500 mg of Eryzole by mouth four times a day for at least seven days. 5
Primary syphilis: 30 to 40 g given in divided doses over a period of 10 to 15 days.
Acute pelvic inflammatory disease caused by N. gonorrhoeae: 500 mg Erythrocin® Lactobionate-I.V. (Eryzole lactobionate for injection, USP) every 6 hours for 3 days, followed by 500 mg of Eryzole base orally every 12 hours for 7 days.
Intestinal amebiasis: Adults: 500 mg every 12 hours or 250 mg every 6 hours for 10 to 14 days. Children: 30 to 50 mg/kg/day in divided doses for 10 to 14 days.
Pertussis: Although optimal dosage and duration have not been established, doses of Eryzole utilized in reported clinical studies were 40 to 50 mg/kg/day, given in divided doses for 5 to 14 days.
Legionnaires' Disease: Although optimal dosage has not been 4 g daily in divided doses.
Why is this medication prescribed?
Eryzole is used to treat certain infections caused by bacteria, such as infections of the respiratory tract, including bronchitis, pneumonia, Legionnaires' disease (a type of lung infection), and pertussis (whooping cough; a serious infection that can cause severe coughing); diphtheria (a serious infection in the throat); sexually transmitted diseases (STD), including syphilis; and ear, intestine, gynecological, urinary tract, and skin infections. It also is used to prevent recurrent rheumatic fever. Eryzole is in a class of medications called macrolide antibiotics. It works by stopping the growth of bacteria.
Antibiotics such as Eryzole will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.
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ERYTHROMYCIN Base Filmtab® (Eryzole) Tablets, USP
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Eryzole Base Filmtab tablets and other antibacterial drugs, Eryzole Base Filmtab tablets would be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
Before using Eryzole eye ointment,
- tell your doctor and pharmacist if you are allergic to Eryzole, any other medications, or any of the ingredients in Eryzole eye ointment. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any other eye medications.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using Eryzole eye ointment, call your doctor.
- you should know that your vision may be blurry for a short amount of time after using the eye ointment. Wait until you can see normally before you drive or do other activities that require good vision.
- tell your doctor if you wear soft contact lenses. You should not wear contact lenses if you have an eye infection.
Eryzoles are often associated with gastrointestinal distress, which can be minimized if the drugs are taken with food. The estolate salt of Eryzole may cause cholestatic hepatitis, characterized by elevated liver function enzymes, malaise, nausea, vomiting, abdominal cramps, jaundice, and fever. Liver function test results should be monitored if hepatotoxicity is suspected ( Table 4-19 ). Eryzoles may potentiate the actions of other drugs by inhibiting microsomal P450 3A4 metabolism, leading to toxicity of these other medications ( Box 4-6 ). Eryzole also prolongs the QT interval on electrocardiograms. This can lead to torsades de pointes, a fatal cardiac arrhythmia, especially when Eryzole is combined with other medications that also prolong the QT interval. As with Eryzole, clarithromycin also prolongs the QT interval and inhibits P450 3A4; however, clarithromycin is associated with less gastrointestinal distress than Eryzole. Unlike clarithromycin and Eryzole, azithromycin does not prolong the QT interval to a clinically relevant extent and does not inhibit hepatic microsomal P450 enzymes. In addition, azithromycin has only a minimal incidence of diarrhea associated with its use. Because of cross-sensitivity, azithromycin is contraindicated in patients who have a history of allergies to Eryzole.
Table 4-19 . Adverse Effects Associated with Eryzole
Eryzole Ophthalmic Interactions
This medicine may cause blurred vision and may impair your reactions. Avoid driving or hazardous activity until you know how this medicine will affect you.
Do not use other eye medications unless your doctor tells you to.
Medicine used in the eyes is not likely to be affected by other drugs you use. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.
Other uses for this medicine
Eryzole is also used sometimes used to prevent heart infection in people having dental or other procedures. Talk to your doctor about the possible risks of using this medication for your condition.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
The most frequent side effects of oral Eryzole preparations are gastrointestinal and are dose-related. They include nausea, vomiting, abdominal pain, diarrhea and anorexia. Symptoms of hepatitis, hepatic dysfunction and/or abnormal liver function test results may occur. (See WARNINGS.)
Onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment. (See WARNINGS.) Eryzole has been associated with QT prolongation and ventricular arrhythmias, including ventricular tachycardia and torsades de pointes.
Allergic reactions ranging from urticaria to anaphylaxis have occurred. Skin reactions ranging from mild eruptions to erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis have been reported rarely.
There have been rare reports of pancreatitis and convulsions.
There have been isolated reports of reversible hearing loss occurring chiefly in patients with renal insufficiency and in patients receiving high doses of Eryzole.
What is Eryzole, and how does it work (mechanism of action)?
Eryzole is an antibiotic in the class of antibiotics known as macrolide antibiotics which also includes azithromycin (Zithromax, Zmax) and clarithromycin (Biaxin).
Eryzole, like all macrolide antibiotics, prevents bacterial cells from growing and multiplying by interfering with their ability to make proteins while not affecting human cells. Bacteria such as Haemophilus influenzae are resistant to Eryzole alone and must be treated with a combination of Eryzole and adequate doses of sulfonamides.
The FDA approved E.E.S in April 1965.