Erytab gel

Erytab

  • Active Ingredient: Erythromycin
  • 500 mg, 250 mg
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What is Erytab?

The active ingredient of Erytab brand is erythromycin. Erythromycin is a macrolide antibiotic. Erythromycin fights bacteria in the body.

Used for

Erytab is used to treat diseases such as: Bacterial Endocarditis Prevention, Bartonellosis, Bowel Preparation, Bronchitis, Bullous Pemphigoid, Campylobacter Gastroenteritis, Chancroid, Chlamydia Infection, Dental Abscess, Legionella Pneumonia, Lyme Disease, Lymphogranuloma Venereum, Mycoplasma Pneumonia, Nongonococcal Urethritis, Ocular Rosacea, Otitis Media, Pemphigoid, Pertussis, Pharyngitis, Pneumonia, Rheumatic Fever Prophylaxis, Skin or Soft Tissue Infection, Strep Throat, Syphilis, Early, Upper Respiratory Tract Infection.

Side Effect

Possible side effects of Erytab include: bloating; red skin lesions, often with a purple center; difficulty with swallowing; joint or muscle pain; dark urine; redness of the skin; cough.

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What are the uses for Erytab?

Erytab is used to treat:

  • Streptococcal infections of the throat ("strep throat") and skin
  • Lung infections, for example, pneumonia caused by streptococcal pneumoniae, mycoplasma pneumoniae, and legionella pneumophila (legionnaires disease)
  • Pelvic inflammatory disease
  • Erythrasma
  • Whooping cough
  • Listeriosis
  • Intestinal amebiasis

It is used for the treatment of staphylococcal infections of the skin and as an alternative antibiotic for the treatment of syphilis, gonorrhea, and chlamydia.

Erytab is used in patients who are allergic to penicillin for the prevention of recurrent rheumatic fever and infections of the hearts' valves (endocarditis) in patients with valvular abnormalities of the heart before they undergo dental treatments.

The non-FDA approved uses for Erytab include acne, Lyme disease, and tetanus.

What other drugs will affect Erytab?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can interact with Erytab, and some drugs should not be used at the same time. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

Erytab

Erytab , a natural product isolated from Saccharopolyspora erythraea (formerly Streptomyces) in 1949, was first approved for clinical use in 1952. Erytab is degraded by gastric acid and has long been associated with stimulation of motilin receptors in the stomach and possibly in the colon, leading to adverse gastrointestinal side effects, including cramping and diarrhea. 68,69 Many preparations have attempted to bypass exposure of Erytab to gastric acid, thereby avoiding products of macrolide hydrolysis. These preparations include enteric coating of orally administered tablets, delayed-release formulations, polymer coating of beads, and various formulations of salts and esters. 70 The lactobionate salt used for intravenous administration of Erytab can cause phlebitis at the site of injection.

Erytab is used for the treatment of group A streptococcal infections in children who are allergic to penicillin. Erytab is an alternative treatment for both streptococcal pharyngitis and streptococcal or staphylococcal impetigo. The usefulness of Erytab for respiratory tract infections caused by S. pneumoniae has been greatly diminished by the development of widespread resistance to the macrolides. 42 Macrolide therapy of upper respiratory tract infections (otitis media and sinusitis) or lower respiratory tract infections (pneumonia) potentially caused by S. pneumoniae has a relatively high likelihood of failure, particularly in younger children, who are at highest risk for infections caused by antibiotic-resistant strains. For upper respiratory tract infections, Erytab has inadequate activity against H. influenzae and must be paired with another agent such as a sulfonamide for empiric therapy. Macrolides are effective therapy for pneumonia caused by Mycoplasma pneumoniae, Chlamydophila pneumoniae, or Legionella pneumophila.

Erytab and azithromycin are the preferred antibiotics for treatment of Campylobacter gastroenteritis caused by susceptible strains. Erytab also remains the most appropriate therapy for diphtheria (Corynebacterium diphtheriae). Erytab, clarithromycin, and azithromycin are recommended for treatment or prophylaxis of pertussis (Bordetella pertussis). 71 Azithromycin is preferred for treatment or prophylaxis for pertussis in neonates, based on concerns for the development of pyloric stenosis. 71 Efficacy of Erytab also has been demonstrated in infections caused by Chlamydophila pneumoniae and Chlamydia trachomatis, including neonatal conjunctivitis and pneumonia, as well as urogenital infections during pregnancy. Erytab is active in vitro against Ureaplasma urealyticum, but its role in the treatment of neonatal infections associated with this organism is not well defined. 72

Precautions

Before taking Erytab, tell your doctor or pharmacist if you are allergic to it; or to other macrolide antibiotics (such as azithromycin, clarithromycin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, a certain type of muscle disease (myasthenia gravis).

Erytab may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using Erytab, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using Erytab safely.

Erytab may cause live bacterial vaccines (such as typhoid vaccine) to not work as well. Do not have any immunizations/vaccinations while using this medication unless your doctor tells you to.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Some Erytab products may contain sodium. Ask your doctor or pharmacist for more information if you are on a salt-restricted diet or if you have a condition such as congestive heart failure that could be worsened by an increase in salt intake.

Older adults may be more sensitive to the side effects of this drug, especially hearing loss and QT prolongation (see above).

Tell your doctor if you are pregnant before using this medication.

This medication passes into breast milk. Consult your doctor before breast-feeding.

Important Information

Some medicines can cause unwanted or dangerous effects when used with Erytab. Your doctor may need to change your treatment plan if you use cisapride, pimozide, ergotamine, or dihydroergotamine.

Before you take Erytab, tell your doctor if you have liver disease, myasthenia gravis, a heart rhythm disorder, a history of Long QT syndrome, or low levels of potassium or magnesium in your blood.

Take this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Erytab will not treat a viral infection such as the common cold or flu.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking Erytab and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

How should this medicine be used?

Erytab comes as a capsule, tablet, delayed-release (releases the medication in the intestine to prevent break-down of the medication by stomach acids) capsule, delayed-release tablet, and an oral suspension (liquid) to take by mouth. It usually is taken with or without food every 6 hours (four times a day), every 8 hours (three times a day), or every 12 hours (twice a day). Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Erytab exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the suspension well before each use to mix the medication evenly.

If you are taking the suspension, do not use a household spoon to measure your dose. Use the measuring spoon, dropper, or cup that came with the medication or use a spoon made especially for measuring medication.

Swallow the capsules and tablets whole with a full glass of water; do not chew or crush them.

Continue to take Erytab even if you feel well. Do not stop taking Erytab without talking to your doctor.

1. About Erytab

Erytab is an antibiotic.

Erytab is used in children, often to treat ear infections or chest infections.

The medicine is available on prescription as tablets, capsules, or a liquid that you drink.

It's also available as a skin solution to treat skin infections like acne. It can be given by injection, but this is usually only done in hospital.

Erytab Warnings

You should not take Erytab if:

  • You are allergic to Erytab or any of its inactive ingredients
  • You are taking medications that can change the electrical activity in the heart

Talk to your doctor before taking Erytab if you:

  • Have irregular heartbeat, including ventricular arrhythmia
  • Take colchicine
  • Are taking drugs that are known to interact with Erytab
  • Have liver disease

Erytab may cause sudden death if taken with other medications that are broken down by the liver the same way (see "Drug Interactions").

Taking Erytab for a long period of time may make you more likely to develop infections caused by bacteria or fungus that are much more difficult to treat.


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