Eryrox tablets

Eryrox

  • Active Ingredient: Erythromycin
  • 500 mg, 250 mg
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What is Eryrox?

The active ingredient of Eryrox brand is erythromycin. Erythromycin is a macrolide antibiotic. Erythromycin fights bacteria in the body.

Used for

Eryrox is used to treat diseases such as: Bacterial Endocarditis Prevention, Bartonellosis, Bowel Preparation, Bronchitis, Bullous Pemphigoid, Campylobacter Gastroenteritis, Chancroid, Chlamydia Infection, Dental Abscess, Legionella Pneumonia, Lyme Disease, Lymphogranuloma Venereum, Mycoplasma Pneumonia, Nongonococcal Urethritis, Ocular Rosacea, Otitis Media, Pemphigoid, Pertussis, Pharyngitis, Pneumonia, Rheumatic Fever Prophylaxis, Skin or Soft Tissue Infection, Strep Throat, Syphilis, Early, Upper Respiratory Tract Infection.

Side Effect

Possible side effects of Eryrox include: chills; unusual weight loss; puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue; red skin lesions, often with a purple center; dark urine; red, irritated eyes; swelling of the feet or lower legs.

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Eryrox

Eryrox , a natural product isolated from Saccharopolyspora erythraea (formerly Streptomyces) in 1949, was first approved for clinical use in 1952. Eryrox is degraded by gastric acid and has long been associated with stimulation of motilin receptors in the stomach and possibly in the colon, leading to adverse gastrointestinal side effects, including cramping and diarrhea. 68,69 Many preparations have attempted to bypass exposure of Eryrox to gastric acid, thereby avoiding products of macrolide hydrolysis. These preparations include enteric coating of orally administered tablets, delayed-release formulations, polymer coating of beads, and various formulations of salts and esters. 70 The lactobionate salt used for intravenous administration of Eryrox can cause phlebitis at the site of injection.

Eryrox is used for the treatment of group A streptococcal infections in children who are allergic to penicillin. Eryrox is an alternative treatment for both streptococcal pharyngitis and streptococcal or staphylococcal impetigo. The usefulness of Eryrox for respiratory tract infections caused by S. pneumoniae has been greatly diminished by the development of widespread resistance to the macrolides. 42 Macrolide therapy of upper respiratory tract infections (otitis media and sinusitis) or lower respiratory tract infections (pneumonia) potentially caused by S. pneumoniae has a relatively high likelihood of failure, particularly in younger children, who are at highest risk for infections caused by antibiotic-resistant strains. For upper respiratory tract infections, Eryrox has inadequate activity against H. influenzae and must be paired with another agent such as a sulfonamide for empiric therapy. Macrolides are effective therapy for pneumonia caused by Mycoplasma pneumoniae, Chlamydophila pneumoniae, or Legionella pneumophila.

Eryrox and azithromycin are the preferred antibiotics for treatment of Campylobacter gastroenteritis caused by susceptible strains. Eryrox also remains the most appropriate therapy for diphtheria (Corynebacterium diphtheriae). Eryrox, clarithromycin, and azithromycin are recommended for treatment or prophylaxis of pertussis (Bordetella pertussis). 71 Azithromycin is preferred for treatment or prophylaxis for pertussis in neonates, based on concerns for the development of pyloric stenosis. 71 Efficacy of Eryrox also has been demonstrated in infections caused by Chlamydophila pneumoniae and Chlamydia trachomatis, including neonatal conjunctivitis and pneumonia, as well as urogenital infections during pregnancy. Eryrox is active in vitro against Ureaplasma urealyticum, but its role in the treatment of neonatal infections associated with this organism is not well defined. 72

SIDE EFFECTS

The most frequent side effects of oral Eryrox preparations are gastrointestinal and are dose-related. They include nausea, vomiting, abdominal pain, diarrhea and anorexia. Symptoms of hepatitis, hepatic dysfunction and/or abnormal liver function test results may occur. (See WARNINGS.)

Onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment. (See WARNINGS.) Eryrox has been associated with QT prolongation and ventricular arrhythmias, including ventricular tachycardia and torsades de pointes.

Allergic reactions ranging from urticaria to anaphylaxis have occurred. Skin reactions ranging from mild eruptions to erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis have been reported rarely.

There have been rare reports of pancreatitis and convulsions.

There have been isolated reports of reversible hearing loss occurring chiefly in patients with renal insufficiency and in patients receiving high doses of Eryrox.

Pregnancy and Eryrox

Eryrox is a pregnancy category B drug, which means it should be generally safe to use in pregnancy.

Regardless, you should tell your doctor if you are pregnant or plan to become pregnant before taking this medication.

Since Eryrox has been found to pass into breast milk, it's best to tell your doctor if you are breastfeeding or plan to breastfeed.

Spectrum of activity

Eryrox has a similar spectrum of activity to broad-spectrum penicillins and is often used for treating individuals who are allergic to penicillin. It is effective against Gram-positive bacteria and gut anaerobes but has poor activity against H. influenzae. It is also used for infections by Legionella, Mycoplasma, Chlamydia, Mycobacterium and Campylobacter species and for Bordetella pertussis. Although Eryrox is primarily bacteriostatic, it is bactericidal at high concentrations for some Gram-positive species, such as group A streptococci and pneumococci.

Azithromycin has less activity than Eryrox against Gram-positive bacteria but enhanced activity against H. influenzae. Clarithromycin has slightly greater activity than Eryrox and is also used as part of the multi-drug treatment of H. pylori (see Chapter 33 ). Telithromycin is a derivative of Eryrox active against penicillin- and Eryrox-resistant S. pneumoniae.

Generic Name: Eryrox (oral/injection) (er ITH roe MYE sin)Brand Names: E.E.S. Granules, E.E.S.-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab

Medically reviewed by Sanjai Sinha, MD Last updated on Dec 20, 2018.

INDICATIONS

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Eryrox Base Filmtab tablets and other antibacterial drugs, Eryrox Base Filmtab (Eryrox tablets) tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Eryrox Base Filmtab (Eryrox tablets) tablets are indicated in the treatment of infections caused by susceptible strains of the designated microorganisms in the diseases listed below:

Upper respiratory tract infections of mild to moderate degree caused by Streptococcus pyogenes; Streptococcus pneumoniae; Haemophilus influenzae (when used concomitantly with adequate doses of sulfonamides, since many strains of H. influenzae are not susceptible to the Eryrox concentrations ordinarily achieved). (See appropriate sulfonamide labeling for prescribing information.)

Lower respiratory tract infections of mild to moderate severity caused by Streptococcus pyogenes or Streptococcus pneumoniae.

Respiratory tract infections due to Mycoplasma pneumoniae.

Skin and skin structure infections of mild to moderate severity caused by Streptococcus pyogenes or Staphylococcus aureus (resistant staphylococci may emerge during treatment).

Pertussis (whooping cough) caused by Bordetella pertussis. Eryrox is effective in eliminating the organism from the nasopharynx of infected individuals, rendering them noninfectious. Some clinical studies suggest that Eryrox may be helpful in the prophylaxis of pertussis in exposed susceptible individuals.

Diphtheria: Infections due to Corynebacterium diphtheriae, as an adjunct to antitoxin, to prevent establishment of carriers and to eradicate the organism in carriers.

Erythrasma-In the treatment of infections due to Corynebacterium minutissimum.

Intestinal amebiasis caused by Entamoeba histolytica (oral Eryroxs only). Extraenteric amebiasis requires treatment with other agents.

Acute pelvic inflammatory disease caused by Neisseria gonorrhoeae: Erythrocin® Lactobionate-I.V. (Eryrox lactobionate for injection, USP) followed by Eryrox base orally, as an alternative drug in treatment of acute pelvic inflammatory disease caused by N. gonorrhoeae in female patients with a history of sensitivity to penicillin. Patients should have a serologic test for syphilis before receiving Eryrox as treatment of gonorrhea and a follow-up serologic test for syphilis after 3 months.

Eryroxs are indicated for treatment of the following infections caused by Chlamydia trachomatis: conjunctivitis of the newborn, pneumonia of infancy, and urogenital infections during pregnancy. When tetracyclines are contraindicated or not tolerated, Eryrox is indicated for the treatment of uncomplicated urethral, endocervical, or rectal infections in adults due to Chlamydia trachomatis. 3

When tetracyclines are contraindicated or not tolerated, Eryrox is indicated for the treatment of nongonococcal urethritis caused by Ureaplasma urealyticum. 3

Primary syphilis caused by Treponema pallidum. Eryrox (oral forms only) is an alternative choice of treatment for primary syphilis in patients allergic to the penicillins. In treatment of primary syphilis, spinal fluid should be examined before treatment and as part of the follow-up after therapy.

Legionnaires' Disease caused by Legionella pneumophila. Although no controlled clinical efficacy studies have been conducted, in vitro and limited preliminary clinical data suggest that Eryrox may be effective in treating Legionnaires' Disease.

What are the side effects of Eryrox?

The most frequent side effects of Eryrox are

These gastrointestinal side effects are usually dose-related, i.e., more pronounced with higher doses.

Allergic reactions such as

Missed Dose of Eryrox

If you miss a dose of Eryrox, try to take it as soon as you remember.

However, if it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Don't double up to make up for a missed dose.

What is the dosage for Eryrox? Should I take it with food?

  • The usual dosage for adults is 250 mg every 6 hours, 333 mg every 8 hours or 500 mg every 12 hours. Doses may be increased up to 4 g/day according to the severity of the infection.
  • In children, the usual dosage is 30 to 50 mg/kg/day with age, weight, and severity of the infection being taken into consideration to determine the appropriate dosage.
  • Eryrox may be taken with or without food; however optimal blood levels of Eryrox are obtained when taken on an empty stomach (at least 30 minutes and preferably 2 hours before or after meals).

Eryrox side effects

Get emergency medical help if you have signs of an allergic reaction to Eryrox (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

severe stomach pain, diarrhea that is watery or bloody;

headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;

hearing problems (rare); or

liver problems - loss of appetite, stomach pain (upper right side), tiredness, easy bruising or bleeding, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Serious side effects may be more likely in older adults, including hearing loss, or a life-threatening fast heart rate.

Common Eryrox side effects may include:

mild diarrhea; or

nausea, vomiting, stomach pain, loss of appetite.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Summary

Eryrox (Ery-Tab, PCE) is an antibiotic prescribed to treat a variety of infections. Side effects, drug interactions, dosage, storage, and pregnancy safety information should be reviewed prior to taking this medication.


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