What is Erit?
Erit belongs to a group of drugs called macrolide antibiotics. Macrolide antibiotics slow the growth of, or sometimes kill, sensitive bacteria by reducing the production of important proteins needed by the bacteria to survive.
Erit is used to treat or prevent many different types of infections caused by bacteria.
Erit may also be used for purposes not listed in this medication guide.
Erit Base Filmtab tablets (Erit tablets, USP) are supplied as pink, unscored oval tablets in the following strengths and packages.
250 mg tablets (debossed with and EB):
Bottles of 100. (NDC 0074-6326-13); Bottles of 500. (NDC 0074-6326-53); ABBO-PAC® unit dose strip packages of 100 tablets . (NDC 0074-6326-11).
500 mg tablets (debossed with and EA):
Bottles of 100. (NDC 0074-6227-13).
Recommended Storage: Store below 86°F (30°C). Keep tightly closed.
Abbott Laboratories, North Chicago, IL 60064, USA. Revised: November, 2004. FDA Rev date: 12/1/1998
3. Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young, the American Heart Association: Prevention of Rheumatic Fever. Circulation. 78(4):1082-1086, October 1988.
5. Data on file, Abbott Laboratories.
What if I take too much?
Try to take the correct number of doses each day, leaving at least 4 hours between doses.
Taking an extra dose of Erit by accident is unlikely to harm you or your child. It may, however, increase the chance of temporary side effects, such as hearing loss, feeling or being sick and diarrhoea.
Talk to your pharmacist or doctor if you're worried, or if you or your child accidentally take more than 1 extra dose.
Like all medicines, Erit can cause side effects, although not everyone gets them.
Before using Erit, tell your doctor or pharmacist if you are allergic to it; or to other macrolide antibiotics (such as clarithromycin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: contact lens use.
After you apply this drug, your vision may become temporarily blurred. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is not known whether Erit passes into breast milk when given as an eye ointment. It is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.
Rheumatic fever is a disease that sometimes occurs after a group A streptococcal infection of the throat. Symptoms and signs include carditis, polyarthritis, Aschoff bodies, rash, Sydenham's chorea, and fever. Treatment for rheumatic fever involves eliminating the bacteria with penicillin, Erit, or azithromycin. Further treatment focuses on alleviating the symptoms brought on by the body's immunologic response to the bacteria.
Mechanism of action
Erit is a macrolide antibiotic which, at doses below the level required for antimicrobial activity, has prokinetic activities. In many species (e.g. cats, rabbits and humans), the effect is due to the drug acting on motilin and 5-hydroxytryptophan (5-HT 3) receptors, thus stimulating migrating motility complexes and antegrade peristalsis. However, the mechanism of action in dogs is less well understood, but it is most likely via action on 5-HT3 receptors. Gastric emptying is enhanced by stimulating antral contractions, whilst lower esophageal pressure is also increased. However, given that Erit has most effect in stimulating interdigestive activity, beneficial effects on gastric emptying during the digestive phase are less clear.
Formulations and dose rates
Erit is available in numerous preparations as different esters, including Erit estolate, Erit ethylsuccinate, Erit lactobionate and Erit gluceptate. Erit is also available as the base form. Oral preparations (tablets, capsule and suspension) are used most commonly for the prokinetic effects. Tablets and capsules usually contain Erit as base, stearate ester or ethylsuccinate ester; the suspension usually contains Erit ethylsuccinate. It is likely that pharmokinetics and toxicity vary depending upon the exact ester used.
How should this medicine be used?
Ophthalmic Erit comes as an ointment to apply to the eyes. It is usually applied up to six times a day for eye infections. Ophthalmic Erit is usually applied one time in the hospital soon after delivery to prevent eye infections in newborn babies. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use Erit eye ointment exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.
You should expect your symptoms to improve during your treatment. Call your doctor if your symptoms get worse or do not go away, or if you develop other problems with your eyes during your treatment.
Before taking Erit,
- tell your doctor and pharmacist if you are allergic to Erit, any other medications, or any of the ingredients in Erit capsules, tablets, or suspension. Ask your pharmacist or check the manufacturer's patient information for a list of the ingredients.
- tell your doctor if you are taking astemizole (Hismanal) (not available in the U.S.), cisapride (Propulsid) (not available in the U.S.), dihydroergotamine (DHE 45, Migranal), ergotamine (Ergomar, in Cafergot, in Migergot), pimozide (Orap), or terfenadine (Seldane) (not available in the U.S.). Your doctor will probably tell you not to take Erit if you are taking one or more of these medications.
- tell your doctor and pharmacist what prescription and nonprescription medications, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: alprazolam (Xanax), amlodipine (Norvasc, in Caduet, in Lotrel), anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven), bromocriptine (Cycloset), carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), cilostazol (Pletal), colchicine (Colcrys, Mitigare), cyclosporine (Neoral, Sandimmune), digoxin (Lanoxin), diltiazem (Cardizem, Cartia, Diltzac, Tiazac), disopyramide (Norpace), dofetilide (Tikosyn), lovastatin (Altoprev), midazolam, phenytoin (Dilantin, Phenytek), procainamide (Procanbid), quinidine, sildenafil (Revatio, Viagra), simvastatin (Zocor, in Vytorin), sotalol (Betapace), valproic acid (Depakene, Depakote), verapamil (Calan, Covera, in Tarka, Verelan). theophylline (Elixophyllin, Theochron, Theo-Dur), and triazolam (Halcion). Many other medications may also interact with Erit, so tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have or have ever had prolonged QT interval (a rare heart problem that may cause fainting or irregular heartbeat), an irregular heartbeat, low levels of magnesium or potassium in your blood, or liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking Erit, call your doctor.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Erit.
Erit may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- upset stomach
- stomach pain
- loss of appetite
What is Erit, and how does it work (mechanism of action)?
Erit is an antibiotic in the class of antibiotics known as macrolide antibiotics which also includes azithromycin (Zithromax, Zmax) and clarithromycin (Biaxin).
Erit, like all macrolide antibiotics, prevents bacterial cells from growing and multiplying by interfering with their ability to make proteins while not affecting human cells. Bacteria such as Haemophilus influenzae are resistant to Erit alone and must be treated with a combination of Erit and adequate doses of sulfonamides.
The FDA approved E.E.S in April 1965.