Ecin gel

Ecin

  • Active Ingredient: Erythromycin
  • 500 mg, 250 mg
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What is Ecin?

The active ingredient of Ecin brand is erythromycin. Erythromycin is a macrolide antibiotic. Erythromycin fights bacteria in the body.

Used for

Ecin is used to treat diseases such as: Bacterial Endocarditis Prevention, Bartonellosis, Bowel Preparation, Bronchitis, Bullous Pemphigoid, Campylobacter Gastroenteritis, Chancroid, Chlamydia Infection, Dental Abscess, Legionella Pneumonia, Lyme Disease, Lymphogranuloma Venereum, Mycoplasma Pneumonia, Nongonococcal Urethritis, Ocular Rosacea, Otitis Media, Pemphigoid, Pertussis, Pharyngitis, Pneumonia, Rheumatic Fever Prophylaxis, Skin or Soft Tissue Infection, Strep Throat, Syphilis, Early, Upper Respiratory Tract Infection.

Side Effect

Possible side effects of Ecin include: hives or welts; irregular heartbeat recurrent; Blistering, peeling, or loosening of the skin; light-colored stools; difficulty with swallowing; unusual weight loss.

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Ecin and Grapefruit Juice

You should avoid eating grapefruit and drinking grapefruit juice while taking Ecin.

Grapefruit juice slows down how quickly the body is able to break down the Ecin, which could cause Ecin levels in the blood to rise dangerously high.

This is could be life-threatening because Ecin can change heart rhythm and/or electrical activity in the heart.

home drugs a-z list Ecin Base Filmtab(Ecin Tablets) side effects drug center

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Ecin Base Filmtab (Ecin) is macrolide antibiotic used to treat people that are infected with organisms susceptible to Ecin. Some of the diseases Ecin Base Filmtab treats are mild to moderate upper and lower respiratory tract infections, listeriosis, diphtheria, pertussis (whooping cough), skin infections and many others. Ecin Base Filmtab is available in generic form. Common side effects of Ecin Base Filmtabs include:

The adult dose of Ecin Base Filmtab is one 250 mg tablet 4 times per day with a maximum dose of 4 grams per 24 hours while the 500 mg tablet is twice a day (total doses over 1 gram per day should be divided into 4 doses per 24 hours). Pediatric doses range from 30 to 50 mg/Kg/day (milligrams per Kilogram per 24 hours), but should not to exceed 4g per day. Patients are advised to take Ecin Base Filmtab tablets without food, at least ½ hour up to 2 hrs (the preferred time interval) before eating food. Ecin Base Filmtabs may interact with ergotamine, dihydroergotamine, benzodiazepines, HMG-CoA reductase inhibitors, sildenafil, cyclosporine, carbamazepine, tacrolimus, alfentanil, disopyramide, rifabutin, quinidine, methylprednisolone, cilostazol, vinblastine, bromocriptine, cisapride, pimozide, astemizole, terfenadine, hexobarbital, phenytoin, valproate, and astemizole. Tell your doctor if you are pregnant or plan to become pregnant before using Ecin Base Filmtab; it is unknown if it will affect a fetus. Ecin Base Filmtab passes into breast milk. Consult your doctor before breastfeeding.

Our Ecin Base Filmtabs Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Summary

Ecin (Ery-Tab, PCE) is an antibiotic prescribed to treat a variety of infections. Side effects, drug interactions, dosage, storage, and pregnancy safety information should be reviewed prior to taking this medication.

Anthrax

Anthrax is a deadly infectious disease that may be transmitted to humans by infected animals or by biological warfare. There are three types of anthrax: cutaneous, inhalation, and gastrointestinal. Symptoms of cutaneous anthrax include a swollen glands, muscle ache, headache, fever, nausea, vomiting, and a red-brown raised spot that enlarges, blisters, and hardens, forming an ulcer crater with black crust. Symptoms of inhalation anthrax are flu-like and may progress to respiratory distress, shock, coma, and death. Symptoms of gastrointestinal anthrax include loss of appetite, bloody diarrhea, and abdominal pain. Treatment for cutaneous anthrax involves penicillin, tetracycline, Ecin, and ciprofloxin. Inhalation anthrax necessitates treatment with IV therapy with antibiotics.

6. How to cope with s >

What to do about:

  • feeling sick (nausea) - stick to simple meals and do not eat rich or spicy food while you're taking this medicine. It might help to take your Ecin with a meal or snack.
  • being sick (vomiting) and diarrhoea - drink lots of fluids, such as water or squash - take small, frequent sips if you feel sick to avoid dehydration. Signs of dehydration include peeing less than usual or having strong-smelling pee. Do not take any other medicines without speaking to a pharmacist or doctor.
  • stomach cramps - try to rest and relax. It can help to eat and drink slowly and have smaller and more frequent meals. Putting a heat pad or covered hot water bottle on your stomach may also help. If you are in a lot of pain, speak to your pharmacist or doctor.
  • loss of appetite - eat when you would usually expect to be hungry. If it helps, eat smaller meals more often than usual. Snack when you're hungry.
  • bloating and indigestion - try not to eat foods that cause wind (like lentils, peas, beans and onions). Eat smaller meals, eat and drink slowly, and exercise regularly. Pharmacy medicines like simethicone can also help.

What are the uses for Ecin?

Ecin is used to treat:

  • Streptococcal infections of the throat ("strep throat") and skin
  • Lung infections, for example, pneumonia caused by streptococcal pneumoniae, mycoplasma pneumoniae, and legionella pneumophila (legionnaires disease)
  • Pelvic inflammatory disease
  • Erythrasma
  • Whooping cough
  • Listeriosis
  • Intestinal amebiasis

It is used for the treatment of staphylococcal infections of the skin and as an alternative antibiotic for the treatment of syphilis, gonorrhea, and chlamydia.

Ecin is used in patients who are allergic to penicillin for the prevention of recurrent rheumatic fever and infections of the hearts' valves (endocarditis) in patients with valvular abnormalities of the heart before they undergo dental treatments.

The non-FDA approved uses for Ecin include acne, Lyme disease, and tetanus.

Important Information

Some medicines can cause unwanted or dangerous effects when used with Ecin. Your doctor may need to change your treatment plan if you use cisapride, pimozide, ergotamine, or dihydroergotamine.

Before you take Ecin, tell your doctor if you have liver disease, myasthenia gravis, a heart rhythm disorder, a history of Long QT syndrome, or low levels of potassium or magnesium in your blood.

Take this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Ecin will not treat a viral infection such as the common cold or flu.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking Ecin and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Ecin Ophthalmic S >

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using Ecin ophthalmic and call your doctor at once if you have:

  • severe burning, stinging, or irritation after using this medicine; or
  • signs of eye infection--pain, swelling, severe discomfort, crusting or drainage, eyes more sensitive to light.

Common side effects may include:

  • eye redness; or
  • mild eye irritation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

7.18.5.1.3 Pharmacokinetic properties

Ecin , like other macrolide antibiotics, is orally administered. Because of its acid instability, however, Ecin exhibits high interindividual variability in oral bioavailability, with values ranging from 15% to 45%. The maximal plasma concentration after a typical 250–500 mg oral dose is achieved after approximately 4–5 h, and ranges from 0.3 to 3.5 μg mL −1 . Ecin has a low volume of distribution (0.64 L kg −1 ), which contributes to its short half-life (approximately 1.4 h) and necessitates a frequent dosing schedule, typically 250 mg four times a day or 500 mg twice a day. Ecin is metabolized in the liver, and its major metabolites are the demethylated product at the dimethylamino group, the N-oxide of the desosamine, and des-cladinose Ecin, all of which have much reduced antibacterial potency. Ecin and its metabolites are eliminated mainly in bile. In terms of tissue distribution, higher concentrations are found in tissues such as the lung and tonsils than in plasma. Like other macrolides, it accumulates in phagocytic cells. 158 Since phagocytic cells (macrophages) migrate to the site of infection and release the macrolide, this is considered to be significant in raising the local concentration of the antibiotic. Ecin is 65–90% protein bound with α1-glycoprotein as the main binding partner. The key pharmacokinetic values are summarized in Table 1 . 159,160 As mentioned earlier, one serious drawback of Ecin is its instability under acidic conditions such as those encountered in the stomach. With acid catalysis, Ecin undergoes a series of transformations promoted by the proximity of functional groups and by the entropic factors. 161 Scheme 1 demonstrates the initial change that occurs, as an internal acetal develops and quickly loses a molecule of water to form a cyclic enol ether. These transformations irreversibly result in microbiologically inactive products. Due to this vulnerability, Ecin's effectiveness is threatened by both low bioavailability and high interpatient variability. Enteric-coated tablets were developed with some success to protect Ecin from degradation and to mask its bitter taste. 162

Table 1 . Oral pharmacokinetic properties of first- and second-generation macrolides

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Ecin only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2019 Cerner Multum, Inc. Version: 13.01.

How should this medicine be used?

Ophthalmic Ecin comes as an ointment to apply to the eyes. It is usually applied up to six times a day for eye infections. Ophthalmic Ecin is usually applied one time in the hospital soon after delivery to prevent eye infections in newborn babies. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use Ecin eye ointment exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

You should expect your symptoms to improve during your treatment. Call your doctor if your symptoms get worse or do not go away, or if you develop other problems with your eyes during your treatment.

Rheumatic Fever

Rheumatic fever is a disease that sometimes occurs after a group A streptococcal infection of the throat. Symptoms and signs include carditis, polyarthritis, Aschoff bodies, rash, Sydenham's chorea, and fever. Treatment for rheumatic fever involves eliminating the bacteria with penicillin, Ecin, or azithromycin. Further treatment focuses on alleviating the symptoms brought on by the body's immunologic response to the bacteria.

INDICATIONS

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Ecin Base Filmtab tablets and other antibacterial drugs, Ecin Base Filmtab (Ecin tablets) tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Ecin Base Filmtab (Ecin tablets) tablets are indicated in the treatment of infections caused by susceptible strains of the designated microorganisms in the diseases listed below:

Upper respiratory tract infections of mild to moderate degree caused by Streptococcus pyogenes; Streptococcus pneumoniae; Haemophilus influenzae (when used concomitantly with adequate doses of sulfonamides, since many strains of H. influenzae are not susceptible to the Ecin concentrations ordinarily achieved). (See appropriate sulfonamide labeling for prescribing information.)

Lower respiratory tract infections of mild to moderate severity caused by Streptococcus pyogenes or Streptococcus pneumoniae.

Respiratory tract infections due to Mycoplasma pneumoniae.

Skin and skin structure infections of mild to moderate severity caused by Streptococcus pyogenes or Staphylococcus aureus (resistant staphylococci may emerge during treatment).

Pertussis (whooping cough) caused by Bordetella pertussis. Ecin is effective in eliminating the organism from the nasopharynx of infected individuals, rendering them noninfectious. Some clinical studies suggest that Ecin may be helpful in the prophylaxis of pertussis in exposed susceptible individuals.

Diphtheria: Infections due to Corynebacterium diphtheriae, as an adjunct to antitoxin, to prevent establishment of carriers and to eradicate the organism in carriers.

Erythrasma-In the treatment of infections due to Corynebacterium minutissimum.

Intestinal amebiasis caused by Entamoeba histolytica (oral Ecins only). Extraenteric amebiasis requires treatment with other agents.

Acute pelvic inflammatory disease caused by Neisseria gonorrhoeae: Erythrocin® Lactobionate-I.V. (Ecin lactobionate for injection, USP) followed by Ecin base orally, as an alternative drug in treatment of acute pelvic inflammatory disease caused by N. gonorrhoeae in female patients with a history of sensitivity to penicillin. Patients should have a serologic test for syphilis before receiving Ecin as treatment of gonorrhea and a follow-up serologic test for syphilis after 3 months.

Ecins are indicated for treatment of the following infections caused by Chlamydia trachomatis: conjunctivitis of the newborn, pneumonia of infancy, and urogenital infections during pregnancy. When tetracyclines are contraindicated or not tolerated, Ecin is indicated for the treatment of uncomplicated urethral, endocervical, or rectal infections in adults due to Chlamydia trachomatis. 3

When tetracyclines are contraindicated or not tolerated, Ecin is indicated for the treatment of nongonococcal urethritis caused by Ureaplasma urealyticum. 3

Primary syphilis caused by Treponema pallidum. Ecin (oral forms only) is an alternative choice of treatment for primary syphilis in patients allergic to the penicillins. In treatment of primary syphilis, spinal fluid should be examined before treatment and as part of the follow-up after therapy.

Legionnaires' Disease caused by Legionella pneumophila. Although no controlled clinical efficacy studies have been conducted, in vitro and limited preliminary clinical data suggest that Ecin may be effective in treating Legionnaires' Disease.

Diphtheria

Diphtheria is a disease that causes symptoms and signs such as fever, enlarged lymph nodes, and swallowing problems. Ecin is the primary treatment for diphtheria. Vaccines that prevent diphtheria include the DTaP, Tdap, DT, and Td.


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