Common side effects
These common side effects of E-bac happen in more than 1 in 100 people. Keep taking the medicine, but talk to your doctor or pharmacist if these side effects bother you or don't go away:
- feeling sick (nausea)
- being sick (vomiting) and diarrhoea
- stomach cramps
- loss of appetite
- bloating and indigestion
8. Cautions with other medicines
There are some medicines that don't mix well with E-bac.
Tell your doctor if you're taking these medicines before you start E-bac:
- antihistamine medicines, such as astemizole, terfenadine or mizolastine
- an anti-sickness medicine called domperidone
- medicines for mental health problems called pimozide and amisulpride
- migraine medicines called ergotamine and dihrydroergotamine
- a cholesterol-lowering medicine called simvastatin
- a bladder weakness medicine called tolterodine
How to use E-bac Ointment
To apply eye ointment, wash your hands first. To avoid contamination, be careful not to touch the tip of the tube or let it touch your eye, eyelid, or any other surface. Apply to the eyes only. Do not swallow or inject.
Do not wear contact lenses while you are using this medication. Sterilize contact lenses according to the manufacturer's directions, and check with your doctor before you begin using them again.
To apply eye ointments, tilt your head back, look up, and gently pull down the lower eyelid to make a pouch. Place about a half-inch (1 centimeter) strip of ointment into the pouch as directed by your doctor. Gently close the eye and roll the eyeball in all directions to spread the medication. Try not to blink and do not rub the eye. Repeat these steps for your other eye if so directed. Wipe the tip of the ointment tube with a clean tissue to remove extra medication before recapping it. Wait several minutes for your vision to clear before driving or operating machinery.
The dosage is based on your medical condition and response to treatment. Do not increase your dose or use it more often than directed.
If you are using another kind of eye medication (such as drops or ointments), wait at least 5 minutes before applying other medications. Use eye drops before eye ointments to allow the drops to enter the eye.
Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same times each day. Continue using it for the full time prescribed. Stopping the medication too soon may allow the bacteria to continue to grow, which may result in a return of the infection.
Tell your doctor if your condition persists or worsens.
Pregnancy and E-bac
E-bac is a pregnancy category B drug, which means it should be generally safe to use in pregnancy.
Regardless, you should tell your doctor if you are pregnant or plan to become pregnant before taking this medication.
Since E-bac has been found to pass into breast milk, it's best to tell your doctor if you are breastfeeding or plan to breastfeed.
Diphtheria is a disease that causes symptoms and signs such as fever, enlarged lymph nodes, and swallowing problems. E-bac is the primary treatment for diphtheria. Vaccines that prevent diphtheria include the DTaP, Tdap, DT, and Td.
E-bac eye ointment may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- redness, itching, stinging, or burning of the eye
E-bac eye ointment may cause other side effects. Call your doctor if you have any unusual problems while using this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
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To reduce the development of drug-resistant bacteria and maintain the effectiveness of E-bac Base Filmtab tablets and other antibacterial drugs, E-bac Base Filmtab tablets would be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
What are the side effects of E-bac?
E-bac is generally well tolerated. When essential, E-bac can be used in pregnancy and during breastfeeding.
The following side effects may arise.
- Gastrointestinal disturbance: nausea, vomiting, abdominal pain, diarrhoea, loss of appetite
- Liver reactions: more common in those with pre-existing liver disease and potentially serious. Signs are dark urine, light stools, yellow eyes and skin ( jaundice )
- Allergic rashes: hives, fixed drug eruption , Stevens-Johnson– toxic epidermal necrolysis and rarely, anaphylaxis
- Hearing loss: more likely on high doses in those with k >arrhythmias (irregularities of the heartbeat ) have been reported in those with an electrical dysfunction that results in a prolonged Q-T interval on electrocardiograph (ECG). This can be due to congenital or acquired heart conditions or electrolyte disturbance (low potassium or magnesium levels)
E-bac is one of the macrolides, a large group of structurally related antibiotics that inhibit protein synthesis. E-bac has been shown to bind to the large ribosomal subunit in the peptidyltransferase region of the 23S ribosomal RNA (rRNA). Resistance can arise from mutations in at least three different genes encoding large subunit ribosomal proteins. Curiously, in E. coli, genetic elimination of ribosomal protein L11 makes the cells hypersensitive to E-bac. Resistance can also arise from specific mutations in the gene encoding 23S rRNA, mutations which must be constructed in organisms like E. coli that have multiple copies of this gene. These mutations are in a region of the 23S rRNA which is protected by specific methylation in the organism that produces E-bac. Methylation at this site in E. coli leads to E-bac resistance, but the gene that encodes the specific methylase must be acquired by horizontal gene transfer.
You should not take E-bac if:
- You are allergic to E-bac or any of its inactive ingredients
- You are taking medications that can change the electrical activity in the heart
Talk to your doctor before taking E-bac if you:
- Have irregular heartbeat, including ventricular arrhythmia
- Take colchicine
- Are taking drugs that are known to interact with E-bac
- Have liver disease
E-bac may cause sudden death if taken with other medications that are broken down by the liver the same way (see "Drug Interactions").
Taking E-bac for a long period of time may make you more likely to develop infections caused by bacteria or fungus that are much more difficult to treat.
Updated: March 29, 2019
This article was co-authored by Theodore Leng, MD. Dr. Leng is a Board Certified Ophthalmologist and Vitreoretinal Surgeon at Stanford University. He completed his Vitreoretinal surgical fellowship at Stanford University in 2010.
There are 20 references cited in this article, which can be found at the bottom of the page.
If you have a bacterial infection in your eye or your doctor wants to prevent one from happening, then you need an antibiotic, prescribed by a doctor, to treat the problem. One of the most commonly prescribed antibiotics for bacterial eye infections is E-bac. E-bac ointment can help kill infections of the eye caused by bacteria. Some of the most w >
What is E-bac?
E-bac belongs to a group of drugs called macrolide antibiotics. Macrolide antibiotics slow the growth of, or sometimes kill, sensitive bacteria by reducing the production of important proteins needed by the bacteria to survive.
E-bac is used to treat or prevent many different types of infections caused by bacteria.
E-bac may also be used for purposes not listed in this medication guide.
E-bac is available as:
- Tablets: 250, 333, 400 and 500 mg.
- Suspension: 200 and, 400 mg/teaspoon.
- Tablet (Chewable): 200 mg. Powder: 100 mg/half-teaspoon and 200 mg/teaspoon.
- Granules: 200 and 400 mg/teaspoon.
- Powder for Injection: 500 mg and 1g.