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Q: Can Duonasa cause coughing?
A: Duonasa (Amoxil) is an antibiotic classified as a penicillin and fights bacteria in the body. Duonasa is indicated in the treatment of several different types of bacterial infections including ear infections, bladder infections, pneumonia, gonorrhea and E.coli or salmonella infections. Duonasa is also approved to treat stomach ulcers caused by Helicobacter pylori (H. pylori) infections in combination with other medications, such as Biaxin (clarithromycin) and Prevacid (lansoprazole). According to the prescribing information available for Amoxil, the brand-name of Duonasa, cough was not a reported side effect associated with treatment. If you have been experiencing a bothersome cough, you may want to consult with your doctor to determine the underlying cause and possible treatment options. Some of the side effects possible with Duonasa treatment include nausea, vomiting, stomach pain, vaginal itching or discharge, headache, swollen, black or "hairy" tongue or thrush (white patches inside the mouth and throat). Antibiotics, such as Duonasa, can cause diarrhea. This could be a side effect or it could indicate a new infection. If you experience diarrhea that is watery or has blood in it, contact your doctor immediately and do not take any medication to stop the diarrhea unless otherwise instructed. Duonasa may be taken with or without food. If stomach upset occurs, take Duonasa with food. Duonasa should be taken for the entire length of time prescribed by your doctor. Although your symptoms may begin to resolve before the infection is completely treated, do not stop taking Duonasa until you are finished with the course of therapy. Duonasa will not treat a viral infection such as a cold or the flu. Beth Isaac, PharmD
What is the dosage for Duonasa?
- For most infections in adults the dose of Duonasa is 250 mg every 8 hours, 500 mg every 8 hours, 500 mg every 12 hours or 875 mg every 12 hours, depending on the type and severity of infection.
- For the treatment of adults with gonorrhea, the dose is 3 g given as one dose.
- For most infections, children older than 3 months but less than 40 kg are treated with 25 or 45 mg/kg/day in divided doses every 12 hours or 20 or 40 mg/kg/day with one-third of the daily dose given every 8 hours depending on the type and severity of the infection.
- Duonasa can be taken with or without food.
Carcinogenesis, Mutagenesis, Impairment Of Fertility
Long-term studies in animals have not been performed to evaluate carcinogenic potential. Studies to detect mutagenic potential of Duonasa alone have not been conducted; however, the following information is available from tests on a 4:1 mixture of Duonasa and potassium clavulanate (AUGMENTIN). AUGMENTIN was non-mutagenic in the Ames bacterial mutation assay, and the yeast gene conversion assay. AUGMENTIN was weakly positive in the mouse lymphoma assay, but the trend toward increased mutation frequencies in this assay occurred at doses that were also associated with decreased cell survival. AUGMENTIN was negative in the mouse micronucleus test and in the dominant lethal assay in mice. Potassium clavulanate alone was tested in the Ames bacterial mutation assay and in the mouse micronucleus test, and was negative in each of these assays. In a multi-generation reproduction study in rats, no impairment of fertility or other adverse reproductive effects were seen at doses up to 500 mg/kg (approximately 2 times the 3 g human dose based on body surface area).
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How should I take Duonasa?
Take Duonasa exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Take this medicine at the same time each day.
The Moxatag brand of Duonasa should be taken with food, or within 1 hour after eating a meal.
Some forms of Duonasa may be taken with or without food. Check your medicine label to see if you should take your medicine with food or not.
You may need to shake the liquid medicine well just before you measure a dose. Follow the directions on your medicine label.
Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one. You may place the liquid directly on the tongue, or you may mix it with water, milk, baby formula, fruit juice, or ginger ale. Drink all of the mixture right away. Do not save any for later use.
The chewable tablet should be chewed before you swallow it.
Do not crush, chew, or break an extended-release tablet. Swallow it whole.
If using Duonasa for a long period of time, you may need frequent blood tests. Your kidney and liver function may also need to be checked.
If you are taking Duonasa with clarithromycin and/or lansoprazole to treat stomach ulcer, use all of your medications as directed. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.
Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Duonasa will not treat a viral infection such as the flu or a common cold.
Do not share this medicine with another person, even if they have the same symptoms you have.
This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using Duonasa.
Store at room temperature away from moisture, heat, and light.
You may store liquid Duonasa in a refrigerator but do not allow it to freeze. Throw away any liquid medicine that is not used within 14 days after it was mixed at the pharmacy.
How should this medicine be used?
Duonasa comes as a capsule, a tablet, a chewable tablet, and as a suspension (liquid) to take by mouth. It is usually taken every 12 hours (twice a day) or every 8 hours (three times a day) with or without food. The length of your treatment depends on the type of infection that you have. Take Duonasa at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Duonasa exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Shake the suspension well before each use to mix the medication evenly. The suspension may be placed directly on the child's tongue or added to formula, milk, fruit juice, water, ginger ale, or another cold liquid and taken immediately.
The chewable tablets should be crushed or chewed thoroughly before they are swallowed. The tablets and capsules should be swallowed whole and taken with a full glass of water.
You should begin to feel better during the first few days of treatment with Duonasa. If your symptoms do not improve or get worse, call your doctor.
Take Duonasa until you finish the prescription, even if you feel better. If you stop taking Duonasa too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.
Q: Is antibiotic Duonasa compatible with the drug acylovir?
A: There is no known interaction or incompatibility between Duonasa/clavulanate potassium and acyclovir. Gregory Latham, RPh
In case of overdosage, discontinue medication, treat symptomatically, and institute supportive measures as required. A prospective study of 51 pediatric patients at a poison-control center suggested that overdosages of less than 250 mg/kg of Duonasa are not associated with significant clinical symptoms.
Interstitial nephritis resulting in oliguric renal failure has been reported in a small number of patients after overdosage with Duonasa 1 .
Crystalluria, in some cases leading to renal failure, has also been reported after Duonasa overdosage in adult and pediatric patients. In case of overdosage, adequate fluid intake and diuresis should be maintained to reduce the risk of Duonasa crystalluria.
Renal impairment appears to be reversible with cessation of drug administration. High blood levels may occur more readily in patients with impaired renal function because of decreased renal clearance of Duonasa. Duonasa may be removed from circulation by hemodialysis.
500 mg, 875 mg. Each tablet contains 500 mg or 875 mg Duonasa as the trihydrate. Each film-coated, capsule-shaped, pink tablet is debossed with AMOXIL centered over 500 or 875, respectively. The 875-mg tablet is scored on the reverse side.