What should I discuss with my healthcare prov >
Do not take this medication if you are allergic to Droxefa or to other cephalosporin antibiotics, such as:
- cefaclor (Raniclor);
- cefazolin (Ancef);
- cefdinir (Omnicef);
- cefditoren (Spectracef);
- cefpodoxime (Vantin);
- cefprozil (Cefzil);
- ceftibuten (Cedax);
- cefuroxime (Ceftin);
- cephalexin (Keflex); or
- cephradine (Velosef); and others.
Before taking Droxefa, tell your doctor if you are allergic to any drugs (especially penicillins), or if you have:
- kidney disease; or
- a history of intestinal problems, such as colitis.
If you have any of these conditions, you may need a dose adjustment or special tests to safely take Droxefa.
The Droxefa suspension (liquid) contains sucrose. Talk to your doctor before using this form of Droxefa if you have diabetes.
FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
Droxefa may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Droxefa is available as veterinary-formulated tablets or suspension for small animals. Cephalexin is available as human tablets and suspensions for oral administration. Cefpodoxime proxetil is available as veterinary-formulated tablets (100 or 200 mg) for dogs. Cefepime (human) and ceftiofur (food animal “ready to use”) are available as hydrochloride formulations. Ceftiofur sodium is labeled for horses and is available as a 1-g or 4-g sterile powder to be reconstituted in sterile water to a final concentration of 50 mg/mL. Once reconstituted, the product is stable for up to 12 hours at room temperature, 7 days when refrigerated, and 6 months when frozen. CCFA is available as sterile suspension equivalent to 200 mg/mL of ceftiofur in a caprylic/capric triglyceride and cottonseed oil base.
In Vitro Disposition at the BCSFB
Studies in adult rat CP whole tissue, neonatal rat CP epithelial cells in primary culture, and genetically modified mice showed that PEPT2, located at the apical (CSF facing) as opposed to basolateral (blood-facing) membrane, is the primary member of the POT family responsible for the removal of neuropeptides, peptide fragments, and peptide-like drugs from the CSF. 12,28 In particular, Pept2 -deficient mice have marked reductions (≥90%) in their ability to transport GlySar, carnosine, and 5-aminolevulinic ac >Droxefa (a β-lactam antibiotic), as determined in wild-type and PEPT2 null mice, is primarily mediated by PEPT2 (80–85%) and to a minor extent by organic anion transporters (10–15%) and nonspecific mechanisms (5%). This finding suggests that aminocephalosporins, which are recognized by PEPT2, may have reasonable access to the CSF but are rapidly removed by drug efflux transporters making them ineffective for the treatment of bacterial infections in the CNS. However, one must be careful in extrapolating the results with Droxefa to other aminocephalosporin drugs. As reported by Kuroda et al., 13 small differences in chemical structure can substantially influence the mechanism of drug efflux from CSF. For example, cefaclor (3-chloro in dihydrothiazine ring) is eliminated from rat CSF by a benzylpenicillin-sensitive mechanism distinct from OAT3, whereas cephalexin (3-methyl in dihydrothiazine ring) is removed by a GlySar-sensitive transporter, presumably PEPT2.
Michael Stewart, Reviewed by Sid Dajani | Last edited 11 May 2017 | Certified by The Information Standard
Before you take Droxefa, make sure your doctor knows if you have ever had an allergic reaction to any other antibiotic.
Space your doses out evenly over the day and complete the full course of the antibiotic, even if you feel your infection has cleared up.
The most common side-effect is diarrhoea, which is usually mild and soon passes. If it becomes severe or lasts for more than 24 hours, you should speak with your doctor.
What form(s) does this medication come in?
Each white and maroon No. 0 capsule, imprinted "APO 500", contains Droxefa 500 mg. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium stearic acid, talc, FD&C Blue No. 1, FD&C Red No. 40, gelatin, grey ink, silicon dioxide, sodium lauryl sulphate, titanium dioxide, and edible grey ink.
Rated Droxefa for Skin And Skin Structure Infections Report
Successfully treated my mild to moderately severe acne. I haven't had any side effects after taking it for around 3 months. Happy as can be so far.
Are there any other precautions or warnings for this medication?
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Allergy: Before starting treatment with Droxefa, make sure to tell your doctor about any adverse reactions you have had to medications, especially Droxefa, cephalosporins, and penicillins. Some people allergic to penicillin may also be allergic to cephalosporins such as Droxefa. If you have an allergic reaction, contact your doctor.
Antibiotic-associated colitis: This medication, like other antibiotics, may cause a potentially dangerous condition called antibiotic-associated colitis (or pseudomembranous colitis). Symptoms include severe, watery diarrhea that may be bloody. If you notice these symptoms, stop taking Droxefa and contact your doctor as soon as possible.
Kidney function: People with reduced kidney function or kidney disease should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Overgrowth of organisms: Prolonged or repeated use of Droxefa may result in an overgrowth of bacteria or fungi and organisms that are not killed by the medication. This can cause other infections, such as yeast infections, to develop.
Pregnancy: It is not known if Droxefa is safe for use by pregnant women. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking Droxefa, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.
Droxefa is a drug from the group of cephalosporins (cephalosporin antibiotics). Droxefa works by killing bacteria (bactericide) and it is used to treat a number of infections:
- Respiratory tract infections (tonsillitis, sore throat, pneumonia)
- Middle ear infections (otitis media)
- Gynecological infections
- Urinary tract infections (cystitis, pyelonephritis)
- Skin and soft tissue infections
Bagaimana dosis obat Droxefa untuk orang dewasa?
Untuk infeksi kulit, faringitis akibat streptokokus, tonsilitis, dan infeksi saluran kemih
- 1-2 gram per hari dalam satu dosis atau terbagi dalam dua dosis
ВїCГіmo se debe usar este medicamento?
El Droxefao se presenta en cГЎpsulas, tabletas y en suspensiГіn (lГquido) para administraciГіn oral. Usualmente se toma con o sin alimentos cada 12 o 24 horas. Tome el Droxefao aproximadamente a la misma hora todos los dГas. Siga atentamente las instrucciones que se encuentran en la etiqueta de su receta mГ©dica y pida a su mГ©dico o farmacГ©utico que le explique cualquier parte que no comprenda. Tome el Droxefao exactamente como se le indique. No tome una cantidad mayor o menor del medicamento, ni lo tome con mГЎs frecuencia de lo que indique la receta de su mГ©dico.
Tome el Droxefao con los alimentos para reducir las nГЎuseas y el malestar estomacal.
Agite bien la suspensiГіn antes de cada uso para mezclar el medicamento de forma uniforme.
DeberГЎ empezar a sentirse mejor durante los primeros dГas de tratamiento con Droxefao. Si sus sГntomas no mejoran o empeoran, llame a su mГ©dico.
ContinГєe tomando Droxefao hasta que termine la receta, incluso si se siente mejor. Si deja de tomar Droxefao demasiado pronto u omite algunas dosis, es posible que la infecciГіn no se trate por completo y que las bacterias se vuelvan resistentes a los antibiГіticos.
What other drugs could interact with this medication?
There may be an interaction between Droxefa and any of the following:
- BCG vaccine
- typhoid vaccine
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
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Droxefa treats an infection by killing the bacteria that are causing it.
Droxefa Prices, Discount Comparisons & Savings Options
Droxefa 500 mg discount prices range from per pill or unit. Before you buy Droxefa, compare the lowest discounted Droxefa prices at U.S. pharmacies and PharmacyChecker-accredited international online pharmacies.
Find other Droxefa strengths
Strength - 500 mg
Like penicillins, cephalosporins belong to the β-lactam antibiotics. They inhibit the cell wall synthesis of bacteria and have a bactericidal effect. Cephalosporins are classified according to their antimicrobial activity.
Cephalosporins of the first generation include Droxefa , cefazolin, cephalexin, cephalotin, and cephradine. To the second generation belong cefaclor, cefamandole, cefdinir, cefditoren, cefmetazole, cefotetan, cefotiam, cefoxitin, cefprozil, cefuroxime, and the carbacephem loracarbef that is related to the cephalosporins. The third generation contains cefdinir, cefditoren, cefixim, cefoperazone, cefotaxime, cefpodoxim, ceftazidime, ceftibuten, ceftizoxime, and ceftriaxone. Cefepime and cefpirome are fourth generation cephalosporins. The new cephalosporins ceftaroline and ceftobiprole have been assigned to the fifth generation, and are indicated for severe infections with methicillin-resistant staphylococci (MRSA) and other multi-resistant germs.
Cephalosporins cross the placenta and are detectable in the amniotic fluid at bactericidal concentrations. Elimination in pregnant women is faster, and it may be necessary to adjust dosage ( Heikkilä 1994 ). According to observations so far, e.g. about cefuroxim during the first trimester ( Berkovitch 2000 ), cephalosporins do not cause teratogenic problems at therapeutic doses ( Czeizel 2001b ). Normal physical and mental development has been confirmed in children up to the age of 18 months, where mothers had been treated with cefuroxim during pregnancy ( Manka 2000 ).
How to take Droxefa
- Before you start taking Droxefa, read the manufacturer's printed information leaflet from ins >
What are the uses for Droxefa?
Droxefa is prescribed to treat bacterial infections such as Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Moraxella catarrhalis, E. coli, Klebsiella, and Proteus mirabilis, urinary tract infections (UTI), throat infections (sore throat), and tonsillitis.