What are the possible side effects of Doxyderm?
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. This reaction may occur several weeks after you began using Doxyderm.
Call your doctor at once if you have:
- severe stomach pain, diarrhea that is watery or bloody;
- throat irritation, trouble swallowing;
- chest pain, irregular heart rhythm, feeling short of breath;
- little or no urination;
- low white blood cell counts--fever, chills, swollen glands, body aches, weakness, pale skin, easy bruising or bleeding;
- increased pressure inside the skull--severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes; or
- signs of liver or pancreas problems--loss of appetite, upper stomach pain (that may spread to your back), tiredness, nausea or vomiting, fast heart rate, dark urine, jaundice (yellowing of the skin or eyes).
Common side effects may include:
- nausea, vomiting, upset stomach, loss of appetite;
- mild diarrhea;
- skin rash or itching;
- darkened skin color; or
- vaginal itching or discharge.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What Is Doxyderm and How Does It Work?
Doxyderm is a prescription antibiotic medication indicated for the treatment of the following infections and diseases: Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers, respiratory tract infections, urinary tract infections. lymphogranuloma venereum, psittacosis (ornithosis), trachoma, inclusion conjunctivitis, uncomplicated urethral/endocervical/rectal infections in adults, nongonococcal urethritis, relapsing fever, chancroid, plague, tularemia, cholera, campylobacter fetus, brucellosis, bartonellosis, granuloma inguinale, Escherichia coli, enterobacter aerogenes, Shigella species, Acinetobacter species, anthrax, Uncomplicated gonorrhea, Syphilis, Yaws, Listeriosis, Vincent's infection, Actinomycosis, and infections caused by Clostridium species.
In acute intestinal amebiasis, Doxyderm may be a useful adjunct to amebicides.
In severe acne, Doxyderm may be useful adjunctive therapy.
Because many strains of microorganisms have been shown to be resistant to Doxyderm, culture and susceptibility testing are recommended.
Doxyderm is available under the following different brand names: Vibramycin, Monodox, Acticlate, Atridox, Avidoxy, Doxy, Doxycin, Doryx, Oracea, Periostat, Adoxa, Ocudox, and Doryx MPC.
Generic Name: Doxyderm (DOX i SYE kleen)Brand Names: Acticlate, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Mondoxyne NL, Monodox, Morgidox, Oracea, Oraxyl, Periostat Targadox, Vibramycin calcium, Vibramycin Hyclate, Vibramycin monohydrate, Vibra-Tabs
Medically reviewed by Kaci Durbin, MD Last updated on Jul 1, 2019.
Common Side Effects of Doxyderm
Common side effects of Doxyderm include:
- Itching of the rectum or vagina
- Sore mouth
Missed Dose of Doxyderm
Be sure to take Doxyderm exactly as your doctor prescribed.
Skipping doses or not completing the full course of therapy could make the drug less effective.
It could also lead to the development of drug-resistant bacteria ("superbugs") that will not respond to antibiotics in the future.
If you forget to take a dose of Doxyderm, take the missed dose as soon as you remember it.
If it's almost time for your next regular dose, however, skip the missed one.
Don't take twice as much Doxyderm at one time to make up for a missed dose.
Case 1. Cholestatic hepatitis attributed to Doxyderm therapy.
A 32 year old man with fever and cough was treated with Doxyderm for suspected pneumonitis and developed skin rash, abdominal pain and dark urine one day later. Symptoms of fatigue, nausea and pruritus arose and Doxyderm was stopped after 8 days of therapy. His serum enzymes were elevated and he was mildly jaundiced with a total bilirubin of 4.4 mg/dL (Table). He also had eosinophilia (13.5%). He tested negative for antibodies to hepatitis A, B, and C as well as markers of acute CMV and Epstein Barr infection. Autoantibodies were negative, and an abdominal ultrasound was normal. He remained jaundiced for several months and underwent a liver biopsy that showed intrahepatic cholestasis with mild inflammatory changes suggestive of drug induced liver injury. In follow-up at 3 and again at 18 months, all liver tests had returned to normal.
Rated Doxyderm (Oracea, Doryx) for Chlamydia Infection Report
I was prescribed Doxyderm for my chlamydia infection two weeks ago. I took two pills every day for 7 days and during the first week i would feel weak and feverish an hour after taking the meds every single day. This is week two now i am off the meds however I'm experiencing stomach cramps, joint aches vaginal cramps, back aches and slight on and off heasaches. I will be notifying my doctor about my side effects. I hope the side effects pass soon because it is so draining to wonder what if theres something else wrong inside me?!
Rated Doxyderm (Oracea, Doryx) for Skin And Skin Structure Infections Report
Do not take! Chest pains and slow breathing. Went back to hospital it's horrible.
Serious side effects
Serious side effects are rare and happen in less than 1 in 1,000 people.
Call a doctor straight away if you get:
- bruising or bleeding you can't explain (including nosebleeds), a sore throat, a high temperature (38C or above) and you feel tired or generally unwell - these can be signs of blood problems
- diarrhoea (possibly with stomach cramps) that contains blood or mucus - if you have severe diarrhoea that lasts longer than 4 days you should also speak to a doctor
- ringing or buzzing in your ears
- pale poo with dark pee, yellow skin or the whites of your eyes go yellow - this could be a sign of liver problems
- joint or muscle pain that has started since you began taking Doxyderm
- severe headaches, vomiting and problems with your vision - these could be signs of pressure around your brain (intracranial hypertension)
- a fingernail coming away from its base - this could be a reaction to sunlight called photo-onycholysis
- a sore or swollen mouth, lips or tongue
- severe pain in your stomach, with or without bloody diarrhoea, nausea and vomiting - these can be signs of pancreatitis
- difficulty or pain when you swallow, a sore throat, acid reflux, a smaller appetite or chest pain which gets worse when you eat - these could be signs of an inflamed food pipe (oesophagitis) or oesophageal ulcer
GENERIC NAME(S): Doxyderm Calcium
This medication is used to treat a wide variety of bacterial infections, including those that cause acne. This medication is also used to prevent malaria. This medication is known as a tetracycline antibiotic. It works by stopping the growth of bacteria.
This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.
What should I discuss with my healthcare prov >
You should not take this medicine if you are allergic to Doxyderm or other tetracycline antibiotics such as demeclocycline, minocycline, tetracycline, or tigecycline.
To make sure Doxyderm is safe for you, tell your doctor if you have ever had:
- liver disease;
- kidney disease;
- asthma or sulfite allergy;
- increased pressure inside your skull; or
- if you also take isotretinoin, seizure medicine, or a blood thinner such as warfarin (Coumadin).
If you are using Doxyderm to treat gonorrhea, your doctor may test you to make sure you do not also have syphilis, another sexually transmitted disease.
Taking this medicine during pregnancy may affect tooth and bone development in the unborn baby. Taking Doxyderm during the last half of pregnancy can cause permanent tooth discoloration later in the baby's life. Tell your doctor if you are pregnant or if you become pregnant while using this medicine.
Doxyderm can make birth control pills less effective. Ask your doctor about using a non-hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy.
Doxyderm can pass into breast milk and may affect bone and tooth development in a nursing infant. Do not breast-feed while you are taking Doxyderm.
Doxyderm can cause permanent yellowing or graying of the teeth in children younger than 8 years old. Children should use Doxyderm only in cases of severe or life-threatening conditions such as anthrax or Rocky Mountain spotted fever. The benefit of treating a serious condition may outweigh any risks to the child's tooth development.
Not studied in pregnant patients; the vast majority of reported experience with Doxyderm during human pregnancy is short-term, first trimester exposure; there are no human data available to assess effects of long-term therapy of Doxyderm in pregnant women, such as that proposed for treatment of anthrax exposure; it should not be used in pregnant women unless, in judgment of physician, it is essential for welfare of patient; evidence of embryotoxicity has been noted in animals treated early in pregnancy
- Doxyderm works by interrupting the production of proteins by bacteria. It is effective against a wide variety of bacteria, such as Hemophilus influenzae, Streptococcuspneumoniae, Mycoplasma pneumoniae, Chlamydia psittaci, Chlamydia trachomatis, Neisseria gonorrhoea, and many others.
How should I take Doxyderm?
Take Doxyderm exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Take Doxyderm with a full glass of water. Drink plenty of liquids while you are taking this medicine.
Most brands of doxycyline may be taken with food or milk if the medicine upsets your stomach. Different brands of Doxyderm may have different instructions about taking them with or without food.
Take Oracea on an empty stomach, at least 1 hour before or 2 hours after a meal.
You may open a regular capsule or break up a regular tablet and sprinkle the medicine into a spoonful of applesauce to make swallowing easier. Swallow right away without chewing. Do not save the mixture for later use. Drink a full glass (8 ounces) of cool water right away.
Do not crush, break, or open a delayed-release capsule or tablet. Swallow the pill whole.
You may need to split a Doxyderm tablet to get the correct dose. Follow your doctor's instructions.
Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
If you take Doxyderm to prevent malaria: Start taking the medicine 1 or 2 days before entering an area where malaria is common. Continue taking the medicine every day during your stay and for at least 4 weeks after you leave the area. Use protective clothing, insect repellents, and mosquito netting around your bed to further prevent mosquito bites that could cause malaria.
Doxyderm is usually given by injection only if you are unable to take the medicine by mouth. A healthcare provider will give you this injection as an infusion into a vein.
Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Doxyderm will not treat a viral infection such as the flu or a common cold.
If you need surgery, tell the surgeon ahead of time that you are using Doxyderm.
Store at room temperature away from moisture, heat and light.
Throw away any unused medicine after the expiration date on the label has passed. Using expired Doxyderm can cause damage to your kidneys.
Q: I take Periostat 20 mg. When is the best time to take it in terms of food intake?
A: Doxyderm is a tetracycline antibiotic that fights bacteria in the body. It is used to treat many different bacterial infections, such as urinary tract infections, acne, gonorrhea, and chlamydia, periodontitis (gum disease), and others. Doxyderm can also be used to treat the blemishes, bumps, and acne-like lesions caused by rosacea. However, it will not help the facial redness caused by rosacea. The Periostat brand of Doxyderm should be taken on an empty stomach. This means either one hour before a meal or two hours after a meal. Make sure to take Periostat with a full 8 oz. glass of water to wash down all of the drug. This will help reduce the risk of esophageal irritation and ulceration. Common side effects of Periostat include mild nausea, stomach upset, vomiting, and diarrhea. This is not a complete list of side effects that can occur with Periostat. Consult your doctor or health care provider if you experience side effects that become severe or bothersome. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Sarah Lewis, PharmD