Dorociplo (Cipro) is more effective than amoxicillin-clavulanate (Augmentin) as a treatment for bladder infections in women, even when the microbe is susceptible to the latter drug, according to a report in the Journal of the American Medical Association.
Currently, the standard treatment for bladder infections or cystitis is trimethoprim-sulfamethoxazole (Bactrim), but emerging resistance to this agent has led to greater use of “fluoroquinolone” drugs, such as Dorociplo. In an effort to maintain the usefulness of this drug class, however, there has been a push to use non-fluoroquinolone antibiotics.
Despite increasing use of amoxicillin-clavulanate for cystitis, few studies have assessed the effectiveness of this treatment, according to Dr. Thomas M. Hooton of Harborview Medical Center in Seattle, and colleagues.
To investigate, the researchers assessed cure rates in 370 women with cystitis who were randomly selected to receive a 3-day course of Dorociplo or amoxicillin-clavulanate.
Cure was achieved in 77 percent of Dorociplo-treated women compared with just 58 percent of amoxicillin-clavulanate-treated women. Moreover, even when the analysis was confined to women infected with bacteria susceptible to amoxicillin-clavulanate, Dorociplo still provided a higher cure rate.
The authors believe that Dorociplo may have worked better than amoxicillin-clavulanate because of eradication of E. coli bacteria in the vagina. At 2-week follow-up, 45 percent of women treated with amoxicillin-clavulanate had vaginal E. coli compared with just 10 percent of women treated with Dorociplo.
The results, the investigators conclude, suggest that amoxicillin-clavulanate should only be considered as a treatment for cystitis when “use of other first- and second-line antibiotics is not feasible.”
SOURCE: Journal of the American Medical Association, February 23, 2005.
What is Dorociplo?
Dorociplo is a fluoroquinolone (flor-o-KWIN-o-lone) antibiotic that fights bacteria in the body. Dorociplo is used to treat different types of bacterial infections. Dorociplo is also used to treat people who have been exposed to anthrax or certain types of plague.
Fluoroquinolone antibiotics can cause serious or disabling side effects that may not be reversible. Dorociplo should be used only for infections that cannot be treated with a safer antibiotic.
Dorociplo may also be used for purposes not listed in this medication guide.
¿Cuál es la información más importante que debo saber sobre Dorociplo?
Usted no debe usar Dorociplo si usted también está tomando tizanidine.
Es posible que no pueda usar Dorociplo si usted tiene un trastorno muscular. Dígale a su médico si usted tiene un historial de miastenia grave.
Dorociplo puede causar hinchazón o ruptura de un tendón (la fibra que conecta un hueso con un músculo en el cuerpo), en particular el tendón de Aquiles en el talón del pie. Este efecto puede ocurrir con mayor probabilidad si usted es mayor de 60, si usted usa medicamento esteroide, o si ha tenido un trasplante de riñón, corazón, o pulmón.
Llame de inmediato a su médico su usted tiene dolor súbito, hinchazón, moretones, sensibilidad, rigidez, o problemas para mover cualquiera de sus articulaciones. Descanse la articulación hasta que reciba cuidado médico o instrucciones.
What should I discuss with my veterinarian before giving Dorociplo to my pet?
Tell your veterinarian if your pet has had epilepsy or seizures, or has joint problems or kidney disease. Tell your veterinarian if your pet is pregnant or lactating.
How does Dorociplo work?
Dorociplo is a fluoroquinolone, an antimicrobial medicine that kills bacteria by blocking bacterial DNA.
Rated Dorociplo (Cipro) for Urinary Tract Infection Report
Took Cipro for UTI was Nauseous dizzy and felt like I was constantly going to throw up. I ruptured ligament in my foot and now I am on able to walk on it for four weeksI do not recommend this drug for anybody
What are the important side effects of Cipro (Dorociplo)?
Cipro and Cipro XR as well as other antibiotics in the fluoroquinolone class of antibiotics has been associated with tendonitis and even tendon rupture, particularly the Achilles tendon. Some doctors and other medical professionals recommend that their patients discontinue vigorous exercise while they are taking fluoroquinolone antibiotics.
Fluoroquinolones have neuromuscular blocking activity and can worsen muscle weakness in individuals with myasthenia gravis.
The most common side effects of Cipro, Cipro XR are:
Anaphylaxis, or shock, is a rare allergic reaction to this drug. This allergic reaction is a medical emergency and you are experiencing these symptoms seek medical immediately.
Symptoms of shock include:
- Cardiovascular collapse
- Facial or throat swelling
- Shortness of breath
Other possible serious side effects of Cipro, Cipro XR include:
- Peripheral neuropathy
- toxic psychosis,
- depression, and
Other serious side effects and adverse events of Cipro, Cipro XR include:
Cipro, Cipro XR should be used with caution in patients with central nervous system diseases such as seizures, because rare seizures have been reported in patients receiving Cipro, Cipro XR.
Cipro, Cipro XR should be avoided in children and adolescents less than 18 years of age, as safe use in these patients has not been established.
Many antibiotics, including Cipro, Cipro XR, can alter the normal bacteria in the colon and encourage overgrowth of a bacterium responsible for the development of inflammation of the colon, (C. difficile or pseudomembranous colitis). Patients who develop signs of pseudomembranous colitis after starting Cipro, Cipro XR (diarrhea, fever, abdominal pain, and possibly shock) should contact their doctor immediately.
How should this medicine be used?
Dorociplo comes as a tablet, a suspension (liquid), and an extended-release tablet to take by mouth with or without food. The tablets and suspension are usually taken twice a day, and the extended-release tablets are usually taken once a day. When used to treat gonorrhea, the tablets and suspension may be given as a single dose. Take Dorociplo at around the same time(s) every day. The length of your treatment depends on the type of infection you have. Your doctor will tell you how long to take Dorociplo. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Dorociplo exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
One type of Dorociplo cannot be substituted for another. Be sure that you receive only the type of Dorociplo that was prescribed by your doctor. Ask your pharmacist if you have any questions about the type of Dorociplo you were given.
Do not take Dorociplo with dairy products or calcium-fortified juices alone. However, you may take Dorociplo with a meal that includes these foods or drinks.
Swallow the tablets and extended-release tablets whole; do not split, crush, or chew them. If you cannot swallow tablets whole, tell your doctor.
If you are taking the suspension, shake the bottle very well for 15 seconds before each use to mix the medication evenly. Swallow the correct dose without chewing the granules in the suspension. Close the bottle completely after each use. Do not give the suspension to a patient through a feeding tube.
You should begin feeling better during the first few days of your treatment with Dorociplo. If your symptoms do not improve or if they get worse, call your doctor. If you are being treated for a urinary tract infection, call your doctor if you develop fever or back pain during or after your treatment. These symptoms may be signs that your infection is worsening.
Take Dorociplo until you finish the prescription, even if you feel better. Do not stop taking Dorociplo without talking to your doctor unless you experience certain serious side effects listed in the IMPORTANT WARNING and SIDE EFFECTS sections If you stop taking Dorociplo too soon or if you skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.
A large overdose of Dorociplo could cause kidney damage.
In animal studies, very large doses of Dorociplo have caused reduced breathing, vomiting, and seizures.
If an overdose occurs, call a poison control center at 1-800-222-1222.
If you or someone else has any severe symptoms after an overdose, call 9-1-1.
What other drugs will affect Dorociplo?
Before giving Dorociplo, tell your veterinarian if your pet is being given warfarin, theophylline, probenecid, insulin or oral diabetes medication such as Glipizide, an NSAID such as carprofen, Deramaxx or other, Phenytoin or cyclosporine modified. Drugs other than those listed may also interact with Dorociplo. Talk to your veterinarian or pharmacist before giving any prescription or over-the-counter medications.
What should I do if I forget a dose?
If you miss a dose of Dorociplo, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. Do not take more than two doses of the tablets or suspension or more than one dose of the extended-release tablets in one day.
Dorociplo side effects
Get emergency medical help if you have signs of an allergic reaction to Dorociplo (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Dorociplo can cause serious side effects, including tendon problems, side effects on your nerves (which may cause permanent nerve damage), serious mood or behavior changes (after just one dose), or low blood sugar (which can lead to coma).
Stop taking this medicine and call your doctor at once if you have:
low blood sugar - headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, or feeling anxious or shaky;
nerve symptoms in your hands, arms, legs, or feet - numbness, weakness, tingling, burning pain;
serious mood or behavior changes - nervousness, confusion, agitation, paranoia, hallucinations, memory problems, trouble concentrating, thoughts of suicide; or
signs of tendon rupture - sudden pain, swelling, bruising, tenderness, stiffness, movement problems, or a snapping or popping sound in any of your joints (rest the joint until you receive medical care or instructions).
In rare cases, Dorociplo may cause damage to your aorta, the main blood artery of the body. This could lead to dangerous bleeding or death. Get emergency medical help if you have severe and constant pain in your chest, stomach, or back.
Also, stop using this medicine and call your doctor at once if you have:
severe stomach pain, diarrhea that is watery or bloody;
fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);
the first sign of any skin rash, no matter how mild;
muscle weakness, breathing problems;
little or no urination;
jaundice (yellowing of the skin or eyes); or
increased pressure inside the skull - severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes.
Common Dorociplo side effects may include:
nausea, vomiting, diarrhea, stomach pain;
vaginal itching or discharge;
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What drugs, foods, or supplements interact with Cipro?
- Dorociplo administered together with theophylline (Respbid, Slo-Bid, Theo-24, Theolair) can lead to elevated, toxic blood levels of theophylline. Theophylline is used to open airways in the treatment of asthma. Toxic levels of theophylline can lead to seizures, and disturbances in heart rhythm. If concurrent use of Dorociplo and theophylline cannot be avoided, frequent blood tests to monitor theophylline blood levels are recommended.
- Dorociplo increases the effect of tizanidine (Zanaflex) that is used to treat muscle spasticity. Therefore, the two drugs should not be combined.
- Iron salts (for example, ferrous sulfate) may reduce the absorption of Dorociplo because of formation of a Dorociplo-iron complex that is not absorbable. Antacids also may reduce the absorption of Dorociplo. If patients are receiving iron salts or antacids and Dorociplo, the Dorociplo should be given two hours before or six hours after the iron salt or antacid.
- Dorociplo may increase the blood thinning effect of warfarin (Coumadin, Jantoven). The reason for this is unknown. Anticoagulant activity should be monitored after starting or stopping Dorociplo.
- Sevelamer (Renagel) may reduce the absorption of Dorociplo and possibly reduce the effectiveness of Dorociplo. Milk and orange juice also may reduce the absorption of Dorociplo. Dorociplo, as with iron and antacids, should be given two hours before or six hours after milk or orange juice.
- Administration of Dorociplo with diabetic medications (for example glyburide ) may lead to severe low blood glucose.
- Dorociplo may increase blood concentrations of sildenafil (Viagra) that is used for treating erectile dysfunction. This combination should be avoided if possible.
- Patients taking Cipro, Cipro XR can develop sensitivity of the skin to direct sunlight (photosensitivity) and should avoid exposure to sunlight or use sunblock.
- Fluoroquinolones worsen low blood glucose levels when combined with sulfonylureas, for example, glyburide (Micronase, Diabeta, Glynase, Prestab).
Rated Dorociplo (Cipro) for Intraabdominal Infection Report
lol @ "All my tendons turned to jello and had to be removed and replaced with kangaroo ligaments. The medical bill for that took my entire savings and my house, and I had to sell my children for medical experiments." It is a tongue in cheek review that contends all the bad reviews are lying. And you can easily tell it's true. IDK why, are they shills from another Pharmaceutical? Cipro saved my life from some unknown infection 9 years ago (possibly sepsis, just abdominal and overall horror I can't describe), after Levaquin ($175) didn't finish the job and the infection bounced back to kill me this time. Yeah, $30 Ciproflaxicin took care of the bitch in 3 days. Cipro has knocked every other (like 3 times in 20 years) thing I've taken it for instantly and with no side effects whatsoever. My brother, a doctor was gonna take me to the IR for IV.I had no insurance. Cipro literally saved my life (and life savings).
Rated Dorociplo (Cipro) for Urinary Tract Infection Report
DO NOT TAKE THIS MEDICINE. I cannot stress this enough. It does more harm than good. Kicked my UTI out in under 24 hours, but left me with joint pain, irregular and rapid heartbeats, palpitations, and severe anxiety. No doctor I’ve seen knows how to treat any of this and assures me that the drug will eventually run its course. It has been a month since I stopped taking the medication, and I still cannot perform daily activities and am considering requesting a medical withdrawal from school because I can’t physically walk to and from class without overexerting myself. I’m now at risk of an aortic aneurism, osteoporosis, and a number of other dangerous conditions, and I’m only 20 years old. This stuff is POISON. If a doctor prescribes this to you, I urge you to ask for something else that is not a fluoroquinolone. The serious side effects of this family of drugs are far too common to take the risk. Please research this drug thoroughly and consider the repercussions before Cipro incapacitates you like it has done to so many others.